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The map label for this gene is coaBC [H]

Identifier: 78189572

GI number: 78189572

Start: 2109011

End: 2110249

Strand: Reverse

Name: coaBC [H]

Synonym: Cag_1614

Alternate gene names: 78189572

Gene position: 2110249-2109011 (Counterclockwise)

Preceding gene: 78189573

Following gene: 78189571

Centisome position: 82.04

GC content: 50.69

Gene sequence:

>1239_bases
ATGCCCTCTCCTCTTTACAACAAACGCATTCTCCTTGGCGTTAGTGGCGGCATTGCTGCTTATAAAATTCCCCATCTTGT
ACGGCTGCTGAAAAAAGCAGGCGCTGAGGTGCAAGTGGTGATGACGGAACATGCAAAAGAGTTTGTGAGTGAATTAACGC
TTGCAACGCTTTCAGGAAAAACGCCATACAGCGCCATTGTGCCACAGGTGGAGAGCCGAACGCACGATTACACTGCCCAT
ATTTCGCTTGGCGAATGGGCTGATGCGCTGCTGATTGCACCTACTACTGCCAATACGCTTGCAAAGCTTGCAGCAGGTAT
TTGCGACACCATGCTGGGTGCTTGCTTTATCACATTGCGTCCAAGTAAACCGATATTGCTTTTTCCTGCCATGGATGGCG
AAATGTACCGTTCGCCCTCAGTGCAACGGAACCTTGCTACGCTAACGGCAGATGGTTGCACGGTGGTGCCGCCCGAAAGC
GGGGCGCTTGCCTCAGGCTTGTGCGGTGCGGGTAGAATGCCTGAGCCTGATACCATAGTGGCGCACCTTGAGCAAGCGTT
GGCACAAGTGGCACAACCCTCCACGCTTTGCGGTAAATCGGTGGTTATTACGGCGGGACCAACGCGCGAGAAAATTGATG
GCGTCCGTTTTATTTCCAACTACTCATCGGGCAAAATGGGCTTTGCATTGGCGCGTGCGGCGGCACAACGTGGTGCGCGC
GTAACGCTCATTAGCGGTAGCGTCAACCTTGCAACTCCGCTTGGCGTTGAGCGTTTTAATGTGGAAAGTGCTGTGGAGAT
GTATGCGGCGGCAGAGCCATTTTTTGCTTCGGCTGATATTTTTATTGGTGCTGCCGCCGTGGCTGATTATCGTCCAGTTG
AGGTTGTGCAAGGCAAACGCAAAAAAGATGGTACAGCGTTACAACTAACGTTAGTTGAAAATCCCGATATTCTGAAAGCT
TTTGGTCTGCAAAAAAAGGGGCATCAGCTTGCTTGCGGCTTTGCGCTCGAAGGTGAAAATGGTGTGGAATACGCTCGCAA
AAAGCTTCAGGAAAAAGCGCTTGATCTTATTGCGTACAATAGTTTTGATGGCGCAACTTGTGGCTTTGAAGTTGAAACAA
ATATTCTTACCCTCATAGCCCAAAATGGCGAAGCTGTGGCGTTGCCGTTGATGAGTAAAGATGATGCCGCTGCGCACTAC
CTTGATGCACTTGAAGCCCTTATGCGTTCCTGTGTCTAA

Upstream 100 bases:

>100_bases
GCTACTACCCTTTTCATCCGATAAAGCATCCGATAAAACGCCCAATAAGGTGCCCGATAAAGCATCCAATAAAAAAGAGA
ATAAGCCTAACGAATAAACC

Downstream 100 bases:

>100_bases
TGCTATATCAAGCTTATAACCTTAATTATTCATGATTCTTTTATCCTTGTGTCATTCCCGCGAAAGCGCGCAATCCAGAA
TCGTGCAGATAGAGCGGCGG

Product: DNA/pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MPSPLYNKRILLGVSGGIAAYKIPHLVRLLKKAGAEVQVVMTEHAKEFVSELTLATLSGKTPYSAIVPQVESRTHDYTAH
ISLGEWADALLIAPTTANTLAKLAAGICDTMLGACFITLRPSKPILLFPAMDGEMYRSPSVQRNLATLTADGCTVVPPES
GALASGLCGAGRMPEPDTIVAHLEQALAQVAQPSTLCGKSVVITAGPTREKIDGVRFISNYSSGKMGFALARAAAQRGAR
VTLISGSVNLATPLGVERFNVESAVEMYAAAEPFFASADIFIGAAAVADYRPVEVVQGKRKKDGTALQLTLVENPDILKA
FGLQKKGHQLACGFALEGENGVEYARKKLQEKALDLIAYNSFDGATCGFEVETNILTLIAQNGEAVALPLMSKDDAAAHY
LDALEALMRSCV

Sequences:

>Translated_412_residues
MPSPLYNKRILLGVSGGIAAYKIPHLVRLLKKAGAEVQVVMTEHAKEFVSELTLATLSGKTPYSAIVPQVESRTHDYTAH
ISLGEWADALLIAPTTANTLAKLAAGICDTMLGACFITLRPSKPILLFPAMDGEMYRSPSVQRNLATLTADGCTVVPPES
GALASGLCGAGRMPEPDTIVAHLEQALAQVAQPSTLCGKSVVITAGPTREKIDGVRFISNYSSGKMGFALARAAAQRGAR
VTLISGSVNLATPLGVERFNVESAVEMYAAAEPFFASADIFIGAAAVADYRPVEVVQGKRKKDGTALQLTLVENPDILKA
FGLQKKGHQLACGFALEGENGVEYARKKLQEKALDLIAYNSFDGATCGFEVETNILTLIAQNGEAVALPLMSKDDAAAHY
LDALEALMRSCV
>Mature_411_residues
PSPLYNKRILLGVSGGIAAYKIPHLVRLLKKAGAEVQVVMTEHAKEFVSELTLATLSGKTPYSAIVPQVESRTHDYTAHI
SLGEWADALLIAPTTANTLAKLAAGICDTMLGACFITLRPSKPILLFPAMDGEMYRSPSVQRNLATLTADGCTVVPPESG
ALASGLCGAGRMPEPDTIVAHLEQALAQVAQPSTLCGKSVVITAGPTREKIDGVRFISNYSSGKMGFALARAAAQRGARV
TLISGSVNLATPLGVERFNVESAVEMYAAAEPFFASADIFIGAAAVADYRPVEVVQGKRKKDGTALQLTLVENPDILKAF
GLQKKGHQLACGFALEGENGVEYARKKLQEKALDLIAYNSFDGATCGFEVETNILTLIAQNGEAVALPLMSKDDAAAHYL
DALEALMRSCV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=191, Percent_Identity=39.2670157068063, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI87082301, Length=394, Percent_Identity=45.1776649746193, Blast_Score=283, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17560194, Length=181, Percent_Identity=30.939226519337, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=195, Percent_Identity=31.7948717948718, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322925, Length=219, Percent_Identity=26.9406392694064, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324629, Length=111, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24657262, Length=179, Percent_Identity=32.4022346368715, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43594; Mature: 43463

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPLYNKRILLGVSGGIAAYKIPHLVRLLKKAGAEVQVVMTEHAKEFVSELTLATLSGK
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHEECCC
TPYSAIVPQVESRTHDYTAHISLGEWADALLIAPTTANTLAKLAAGICDTMLGACFITLR
CCHHHHCCCHHCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEC
PSKPILLFPAMDGEMYRSPSVQRNLATLTADGCTVVPPESGALASGLCGAGRMPEPDTIV
CCCCEEEEECCCCCHHCCCCHHCCCEEEEECCCEEECCCCCCHHHCCCCCCCCCCCHHHH
AHLEQALAQVAQPSTLCGKSVVITAGPTREKIDGVRFISNYSSGKMGFALARAAAQRGAR
HHHHHHHHHHCCCCHHCCCEEEEECCCCHHHHCHHHEECCCCCCCHHHHHHHHHHHCCCE
VTLISGSVNLATPLGVERFNVESAVEMYAAAEPFFASADIFIGAAAVADYRPVEVVQGKR
EEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCCEECCHHEEEHHHHCCCCCHHHHCCCC
KKDGTALQLTLVENPDILKAFGLQKKGHQLACGFALEGENGVEYARKKLQEKALDLIAYN
CCCCCEEEEEEECCCCHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHEEEEC
SFDGATCGFEVETNILTLIAQNGEAVALPLMSKDDAAAHYLDALEALMRSCV
CCCCCCCCEEEECCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSPLYNKRILLGVSGGIAAYKIPHLVRLLKKAGAEVQVVMTEHAKEFVSELTLATLSGK
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHEECCC
TPYSAIVPQVESRTHDYTAHISLGEWADALLIAPTTANTLAKLAAGICDTMLGACFITLR
CCHHHHCCCHHCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEEEC
PSKPILLFPAMDGEMYRSPSVQRNLATLTADGCTVVPPESGALASGLCGAGRMPEPDTIV
CCCCEEEEECCCCCHHCCCCHHCCCEEEEECCCEEECCCCCCHHHCCCCCCCCCCCHHHH
AHLEQALAQVAQPSTLCGKSVVITAGPTREKIDGVRFISNYSSGKMGFALARAAAQRGAR
HHHHHHHHHHCCCCHHCCCEEEEECCCCHHHHCHHHEECCCCCCCHHHHHHHHHHHCCCE
VTLISGSVNLATPLGVERFNVESAVEMYAAAEPFFASADIFIGAAAVADYRPVEVVQGKR
EEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCCEECCHHEEEHHHHCCCCCHHHHCCCC
KKDGTALQLTLVENPDILKAFGLQKKGHQLACGFALEGENGVEYARKKLQEKALDLIAYN
CCCCCEEEEEEECCCCHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHEEEEC
SFDGATCGFEVETNILTLIAQNGEAVALPLMSKDDAAAHYLDALEALMRSCV
CCCCCCCCEEEECCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]