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The map label for this gene is nadB1 [H]

Identifier: 78189126

GI number: 78189126

Start: 1552616

End: 1554211

Strand: Reverse

Name: nadB1 [H]

Synonym: Cag_1159

Alternate gene names: 78189126

Gene position: 1554211-1552616 (Counterclockwise)

Preceding gene: 78189127

Following gene: 78189121

Centisome position: 60.43

GC content: 47.43

Gene sequence:

>1596_bases
ATGAGTGAAGCAATCACAACCGATGTGTTAGTTATTGGCAGTGGTATTGGCGGGCTTTATTTTGCCCTCCATGCGGCTGA
ATATGCAAGCGTTATCATTATTACCAAAAAAGAGAGCTTTACCTCCAACACCAATTGGGCGCAAGGCGGTATTGCCGCAA
CCATAGACAGCACCGATAGCCCCGATTTGCATATTGCCGATACCCTTGATGCGGGTGCGGGGCTTTGTAATCGTGAAATG
GTATCGCTGATGGTGCACGAGGGACCAAAGCACATTAGCCACTTGCAAGAGCTTGGGGTAAACTTTACTACGGCTGACCA
GCAGCACCTCCATCTTGGCAAAGAGGGAGGGCACTCACGCCACCGCATTGTTCATGCACAAGATTTAACAGGGCGCGAAG
TAGAGATGGCGTTGCTTGAACGCATTAACCACCATCCCAACATTATCCTGCTTGAACATCACTACGCCATTGAGCTGCTT
ACCGAGCATCACCTTGGCATTAAAACCAACGACATCAAATGCTACGGTGCTTATGCGCTTGATTCTGTAAACAACAAAAC
CAAAAAAATTCTTGCCCGCATTACCATGCTTGCAACTGGTGGGCTTGGGCAAATTTACCCATATACCACCAACCCCGATA
TTGCTACGGGCGATGGCGTTGCTATGGGCTACCGCGCAGGTGCCGAAATTGCCAACATGGAGTTTATTCAATTCCACCCA
ACAGCCCTTTACCATCCAGCATGTAGCACCTTTTTAATTTCAGAAGCGGTGCGTGGCTTTGGTGGTATCCTCAAGCTCAA
AGATGGCACGGAGTTTATGCACAAGTATGATCCACGCCAAAACCTTGCACCACGCGATATTGTGGCTCGTGCTATTGATT
CGGAAATCAAAAAAAGTGGCGAACAGTGCGTTTATCTCGATGTTTCACACCTTGAAGCTCAAGCCACCAAAGAGCATTTT
CCCAACATTTATGAAACATGCTTAGGCTACGGTATTGATATGACGCGCGAAATGATTCCCGTTGTGCCAGCCGCTCATTA
CGCTTGTGGTGGCATTAAAACCGACCATCAAGGGCGTACCACTATTGAACGTTTGTACGCTTGCGGTGAAGCAAGTTGCA
CGGGTGTGCATGGCGCTAATCGCCTTGCCAGCAACTCCTTACTTGAAGCTTTAGTGTTTGCATGGCGTGCAGCCGAAGAT
ATTCGCACTACACTTTCCAACTACCATAACGGCACCCATTTTCCTGAGTGGGATGATAGTGGCACGGTTAATCCCGAAGA
GTGGATTTTAGTGTCGCACAACAAGCGCGAAGCACAACAAGTGATGAACGACTACGTAGGCATTGTGCGTAGCGATTTAC
GCCTTCAGCGTGCTCGCCGTCGTATTGATTTCTTAAAAGAAGAGACGGAGGCATATTTCAAAAAAACAAAGGTTACCACT
CAAATTCTTGAACTTCGCAACATCATTAAAGTTGCCAGCTTAGTTATTGAAGGTGCCCTTAAGCGACGTGAATCACGCGG
GTTGCACTACACCACCGACTACCCACAAAAAGACAATCGCCATTTTTTGAATGATACTCTTTTGAGGTCGTTTTAA

Upstream 100 bases:

>100_bases
GCATGTATCTGCCTTTCTATTGAAGTTCCCTAAAAACCCTTGTAACCATTATGGTAACAAGGGTTTTCTTTTAGCCGCTC
TATAAATTTTATTTACAAGC

Downstream 100 bases:

>100_bases
GAGTGGTGGCTTATTTTGGTTGAGATAGGGAAAAATGGAGATGTAACGTTTATTTTTCGTTTGAAGGTGGAAATAACAGT
TGTTGGCGATAATGTCGGCT

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MSEAITTDVLVIGSGIGGLYFALHAAEYASVIIITKKESFTSNTNWAQGGIAATIDSTDSPDLHIADTLDAGAGLCNREM
VSLMVHEGPKHISHLQELGVNFTTADQQHLHLGKEGGHSRHRIVHAQDLTGREVEMALLERINHHPNIILLEHHYAIELL
TEHHLGIKTNDIKCYGAYALDSVNNKTKKILARITMLATGGLGQIYPYTTNPDIATGDGVAMGYRAGAEIANMEFIQFHP
TALYHPACSTFLISEAVRGFGGILKLKDGTEFMHKYDPRQNLAPRDIVARAIDSEIKKSGEQCVYLDVSHLEAQATKEHF
PNIYETCLGYGIDMTREMIPVVPAAHYACGGIKTDHQGRTTIERLYACGEASCTGVHGANRLASNSLLEALVFAWRAAED
IRTTLSNYHNGTHFPEWDDSGTVNPEEWILVSHNKREAQQVMNDYVGIVRSDLRLQRARRRIDFLKEETEAYFKKTKVTT
QILELRNIIKVASLVIEGALKRRESRGLHYTTDYPQKDNRHFLNDTLLRSF

Sequences:

>Translated_531_residues
MSEAITTDVLVIGSGIGGLYFALHAAEYASVIIITKKESFTSNTNWAQGGIAATIDSTDSPDLHIADTLDAGAGLCNREM
VSLMVHEGPKHISHLQELGVNFTTADQQHLHLGKEGGHSRHRIVHAQDLTGREVEMALLERINHHPNIILLEHHYAIELL
TEHHLGIKTNDIKCYGAYALDSVNNKTKKILARITMLATGGLGQIYPYTTNPDIATGDGVAMGYRAGAEIANMEFIQFHP
TALYHPACSTFLISEAVRGFGGILKLKDGTEFMHKYDPRQNLAPRDIVARAIDSEIKKSGEQCVYLDVSHLEAQATKEHF
PNIYETCLGYGIDMTREMIPVVPAAHYACGGIKTDHQGRTTIERLYACGEASCTGVHGANRLASNSLLEALVFAWRAAED
IRTTLSNYHNGTHFPEWDDSGTVNPEEWILVSHNKREAQQVMNDYVGIVRSDLRLQRARRRIDFLKEETEAYFKKTKVTT
QILELRNIIKVASLVIEGALKRRESRGLHYTTDYPQKDNRHFLNDTLLRSF
>Mature_530_residues
SEAITTDVLVIGSGIGGLYFALHAAEYASVIIITKKESFTSNTNWAQGGIAATIDSTDSPDLHIADTLDAGAGLCNREMV
SLMVHEGPKHISHLQELGVNFTTADQQHLHLGKEGGHSRHRIVHAQDLTGREVEMALLERINHHPNIILLEHHYAIELLT
EHHLGIKTNDIKCYGAYALDSVNNKTKKILARITMLATGGLGQIYPYTTNPDIATGDGVAMGYRAGAEIANMEFIQFHPT
ALYHPACSTFLISEAVRGFGGILKLKDGTEFMHKYDPRQNLAPRDIVARAIDSEIKKSGEQCVYLDVSHLEAQATKEHFP
NIYETCLGYGIDMTREMIPVVPAAHYACGGIKTDHQGRTTIERLYACGEASCTGVHGANRLASNSLLEALVFAWRAAEDI
RTTLSNYHNGTHFPEWDDSGTVNPEEWILVSHNKREAQQVMNDYVGIVRSDLRLQRARRRIDFLKEETEAYFKKTKVTTQ
ILELRNIIKVASLVIEGALKRRESRGLHYTTDYPQKDNRHFLNDTLLRSF

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=523, Percent_Identity=32.5047801147228, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1788928, Length=515, Percent_Identity=49.3203883495146, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1790597, Length=536, Percent_Identity=32.2761194029851, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786942, Length=541, Percent_Identity=29.7597042513863, Blast_Score=202, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17550100, Length=539, Percent_Identity=30.6122448979592, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17505833, Length=544, Percent_Identity=30.6985294117647, Blast_Score=208, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI71986328, Length=470, Percent_Identity=27.4468085106383, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322701, Length=541, Percent_Identity=32.5323475046211, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322416, Length=533, Percent_Identity=31.7073170731707, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6320788, Length=484, Percent_Identity=25.8264462809917, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322511, Length=335, Percent_Identity=26.2686567164179, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137288, Length=551, Percent_Identity=31.0344827586207, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24655642, Length=551, Percent_Identity=31.0344827586207, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24655647, Length=551, Percent_Identity=31.0344827586207, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24663005, Length=532, Percent_Identity=31.015037593985, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 59194; Mature: 59063

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAITTDVLVIGSGIGGLYFALHAAEYASVIIITKKESFTSNTNWAQGGIAATIDSTDS
CCCCCEEEEEEEECCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
PDLHIADTLDAGAGLCNREMVSLMVHEGPKHISHLQELGVNFTTADQQHLHLGKEGGHSR
CCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCC
HRIVHAQDLTGREVEMALLERINHHPNIILLEHHYAIELLTEHHLGIKTNDIKCYGAYAL
CEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEHHHHCCCCEEECCEEEEEEHHH
DSVNNKTKKILARITMLATGGLGQIYPYTTNPDIATGDGVAMGYRAGAEIANMEFIQFHP
HCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCCCEEEEEECC
TALYHPACSTFLISEAVRGFGGILKLKDGTEFMHKYDPRQNLAPRDIVARAIDSEIKKSG
CEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
EQCVYLDVSHLEAQATKEHFPNIYETCLGYGIDMTREMIPVVPAAHYACGGIKTDHQGRT
CCEEEEEHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCHHHHCCCCCCCCCCHH
TIERLYACGEASCTGVHGANRLASNSLLEALVFAWRAAEDIRTTLSNYHNGTHFPEWDDS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GTVNPEEWILVSHNKREAQQVMNDYVGIVRSDLRLQRARRRIDFLKEETEAYFKKTKVTT
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QILELRNIIKVASLVIEGALKRRESRGLHYTTDYPQKDNRHFLNDTLLRSF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SEAITTDVLVIGSGIGGLYFALHAAEYASVIIITKKESFTSNTNWAQGGIAATIDSTDS
CCCCEEEEEEEECCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
PDLHIADTLDAGAGLCNREMVSLMVHEGPKHISHLQELGVNFTTADQQHLHLGKEGGHSR
CCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCC
HRIVHAQDLTGREVEMALLERINHHPNIILLEHHYAIELLTEHHLGIKTNDIKCYGAYAL
CEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEHHHHCCCCEEECCEEEEEEHHH
DSVNNKTKKILARITMLATGGLGQIYPYTTNPDIATGDGVAMGYRAGAEIANMEFIQFHP
HCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCCCEEEEEECC
TALYHPACSTFLISEAVRGFGGILKLKDGTEFMHKYDPRQNLAPRDIVARAIDSEIKKSG
CEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
EQCVYLDVSHLEAQATKEHFPNIYETCLGYGIDMTREMIPVVPAAHYACGGIKTDHQGRT
CCEEEEEHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCHHHHCCCCCCCCCCHH
TIERLYACGEASCTGVHGANRLASNSLLEALVFAWRAAEDIRTTLSNYHNGTHFPEWDDS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GTVNPEEWILVSHNKREAQQVMNDYVGIVRSDLRLQRARRRIDFLKEETEAYFKKTKVTT
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QILELRNIIKVASLVIEGALKRRESRGLHYTTDYPQKDNRHFLNDTLLRSF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]