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The map label for this gene is lpxD

Identifier: 78189121

GI number: 78189121

Start: 1547669

End: 1548748

Strand: Reverse

Name: lpxD

Synonym: Cag_1154

Alternate gene names: 78189121

Gene position: 1548748-1547669 (Counterclockwise)

Preceding gene: 78189126

Following gene: 78189111

Centisome position: 60.21

GC content: 43.7

Gene sequence:

>1080_bases
ATGATGACTATTCAAGAAATTTATGAGTATCTCTCTCGTTTTTTTACTCCAGTTGAGCTTATTGGTAATGGCGAAGAGCT
TATTCATGCACCAGCCAAAATTGAGAGTGCTCAAGCGGGAGAGGTAACCTTTGTTGCTAATAAAAAGTATCTCCGTTTTC
TTGCTCTTACCGAAGCTTCGTTAGTGATTGTTGAGCGTTCATTAGCGGTGGAAGAATATGTGGGGAAACACTCTTTTTTA
AAGGTTAATGATCCATATTCGGCGTTTGTTTTTTTACTCCAACGTTTTATTCCACCTCGTCGCATAGCAAAGCAAGGTAT
TGCAGCTACAGCTTCTATTGGTAGTAATGTTACCATAGGTGAGAATGTTAGTATAGGGGAATATGCCGTTATTGGTGAAC
ATTGCTCAATTGGTAACAACACGGTGATTGCTGCCCACTCGGTTTTGCTTGATCATGTTACCATTGGCAGTGATGTAGTG
CTTTTTCCGCACGTAACATGCTATGATGGTACGCGCATTGGCAACCGTGTAGTGATTCATTCTGGTGCTGTTATTGGAGC
TGATGGCTTTGGTTTTGCCCCTCAACAAGATGGTTCTTATATAAAAATTCCTCAGATAGGTATTGTTGAAATTGGCGATG
ATGTAGAAATTGGAGCCAATACCACTATTGATCGTGCAACGCTGGGTAGCACGGTTATTGAATCGGGGGTTAAGTTAGAT
AACCTTGTTCAAGTTGCCCATAACTGCCGTATTGGTGCGCATACGGTTATTGCCGCACAAGCAGGCGTGTCGGGTAGTAC
CACACTTGGTAACCATTGTATTGTTGGTGGACAAGTGGGCTTTGCTGGGCATATTGAGGTGAGTGACCATATTCAAGTGG
CAGCAAAAGCTGGAGTGTCAAAATCATTTATGCAATCGGGGATAGCCTTACGCGGTTATCCAGCGCAACCCATGCGTGAG
CAGTTAAAGTACGAAGCCCAACTGCGCACGGTAGGAGATTTGCACGCAAAACTCAAAGCACTTGAGCAAGAGCTTAAGGC
TTTGCGTGGCAGCGAAATGCCGTTACAAAACACCTTATGA

Upstream 100 bases:

>100_bases
TACCGCTTCCATTTCCCCCTCTTTTTTACTAACTCAGTTGTTTAATTTGTTGATTGTAGCGTATTAAATTTTTTGTGTAA
ACGATAGATAAGAAGCTGCT

Downstream 100 bases:

>100_bases
AAGGTTGCGCGGTACTTGTGATGAGTGATGGTGTATAATTGGCGTTTTTAATGCACAATCCACCACAAAGGTAAAGCGCG
AAGGAAAAGAGAGTAGCACC

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase LpxD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MMTIQEIYEYLSRFFTPVELIGNGEELIHAPAKIESAQAGEVTFVANKKYLRFLALTEASLVIVERSLAVEEYVGKHSFL
KVNDPYSAFVFLLQRFIPPRRIAKQGIAATASIGSNVTIGENVSIGEYAVIGEHCSIGNNTVIAAHSVLLDHVTIGSDVV
LFPHVTCYDGTRIGNRVVIHSGAVIGADGFGFAPQQDGSYIKIPQIGIVEIGDDVEIGANTTIDRATLGSTVIESGVKLD
NLVQVAHNCRIGAHTVIAAQAGVSGSTTLGNHCIVGGQVGFAGHIEVSDHIQVAAKAGVSKSFMQSGIALRGYPAQPMRE
QLKYEAQLRTVGDLHAKLKALEQELKALRGSEMPLQNTL

Sequences:

>Translated_359_residues
MMTIQEIYEYLSRFFTPVELIGNGEELIHAPAKIESAQAGEVTFVANKKYLRFLALTEASLVIVERSLAVEEYVGKHSFL
KVNDPYSAFVFLLQRFIPPRRIAKQGIAATASIGSNVTIGENVSIGEYAVIGEHCSIGNNTVIAAHSVLLDHVTIGSDVV
LFPHVTCYDGTRIGNRVVIHSGAVIGADGFGFAPQQDGSYIKIPQIGIVEIGDDVEIGANTTIDRATLGSTVIESGVKLD
NLVQVAHNCRIGAHTVIAAQAGVSGSTTLGNHCIVGGQVGFAGHIEVSDHIQVAAKAGVSKSFMQSGIALRGYPAQPMRE
QLKYEAQLRTVGDLHAKLKALEQELKALRGSEMPLQNTL
>Mature_359_residues
MMTIQEIYEYLSRFFTPVELIGNGEELIHAPAKIESAQAGEVTFVANKKYLRFLALTEASLVIVERSLAVEEYVGKHSFL
KVNDPYSAFVFLLQRFIPPRRIAKQGIAATASIGSNVTIGENVSIGEYAVIGEHCSIGNNTVIAAHSVLLDHVTIGSDVV
LFPHVTCYDGTRIGNRVVIHSGAVIGADGFGFAPQQDGSYIKIPQIGIVEIGDDVEIGANTTIDRATLGSTVIESGVKLD
NLVQVAHNCRIGAHTVIAAQAGVSGSTTLGNHCIVGGQVGFAGHIEVSDHIQVAAKAGVSKSFMQSGIALRGYPAQPMRE
QLKYEAQLRTVGDLHAKLKALEQELKALRGSEMPLQNTL

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=328, Percent_Identity=37.8048780487805, Blast_Score=210, Evalue=9e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_CHLCH (Q3ARF9)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379459.1
- ProteinModelPortal:   Q3ARF9
- SMR:   Q3ARF9
- STRING:   Q3ARF9
- GeneID:   3747873
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_1154
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- BioCyc:   CCHL340177:CAG_1154-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 38385; Mature: 38385

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTIQEIYEYLSRFFTPVELIGNGEELIHAPAKIESAQAGEVTFVANKKYLRFLALTEAS
CCCHHHHHHHHHHHCCHHEEECCCHHHEECCCCCCCCCCCCEEEEECCCEEEEEEECCCE
LVIVERSLAVEEYVGKHSFLKVNDPYSAFVFLLQRFIPPRRIAKQGIAATASIGSNVTIG
EEEEEHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHCCEEEECCCCCEEEC
ENVSIGEYAVIGEHCSIGNNTVIAAHSVLLDHVTIGSDVVLFPHVTCYDGTRIGNRVVIH
CCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHEECCCCEEEECEEEEECCCCCCCEEEEE
SGAVIGADGFGFAPQQDGSYIKIPQIGIVEIGDDVEIGANTTIDRATLGSTVIESGVKLD
CCEEEECCCCCCCCCCCCCEEECCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCHH
NLVQVAHNCRIGAHTVIAAQAGVSGSTTLGNHCIVGGQVGFAGHIEVSDHIQVAAKAGVS
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHCCCC
KSFMQSGIALRGYPAQPMREQLKYEAQLRTVGDLHAKLKALEQELKALRGSEMPLQNTL
HHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
>Mature Secondary Structure
MMTIQEIYEYLSRFFTPVELIGNGEELIHAPAKIESAQAGEVTFVANKKYLRFLALTEAS
CCCHHHHHHHHHHHCCHHEEECCCHHHEECCCCCCCCCCCCEEEEECCCEEEEEEECCCE
LVIVERSLAVEEYVGKHSFLKVNDPYSAFVFLLQRFIPPRRIAKQGIAATASIGSNVTIG
EEEEEHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHCCEEEECCCCCEEEC
ENVSIGEYAVIGEHCSIGNNTVIAAHSVLLDHVTIGSDVVLFPHVTCYDGTRIGNRVVIH
CCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHEECCCCEEEECEEEEECCCCCCCEEEEE
SGAVIGADGFGFAPQQDGSYIKIPQIGIVEIGDDVEIGANTTIDRATLGSTVIESGVKLD
CCEEEECCCCCCCCCCCCCEEECCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCHH
NLVQVAHNCRIGAHTVIAAQAGVSGSTTLGNHCIVGGQVGFAGHIEVSDHIQVAAKAGVS
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHCCCC
KSFMQSGIALRGYPAQPMREQLKYEAQLRTVGDLHAKLKALEQELKALRGSEMPLQNTL
HHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA