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The map label for this gene is mdh [H]

Identifier: 78189095

GI number: 78189095

Start: 1523220

End: 1524350

Strand: Reverse

Name: mdh [H]

Synonym: Cag_1128

Alternate gene names: 78189095

Gene position: 1524350-1523220 (Counterclockwise)

Preceding gene: 78189098

Following gene: 78189086

Centisome position: 59.27

GC content: 48.28

Gene sequence:

>1131_bases
ATGAACTTTTTTCTTTCAACCGACCTCGTTATCGGTGTAAATGAAGCGCTCAAGCTTAACGAGCATTTGAGCACCATGCC
AATTGCAAAACCTGCAATTATTTACGATGCAAACGTTGCCTCCAGCCTTTACTTTCAAGAGGTGCTGAAAAATCTGCAAG
CCGCATTCCCGAACGCTGTTACCTATTGCAACGACTTTGCTGGTGAGCCAACCTATGCGCACCTCGAAAATGTGGCAACC
ATGTTTCGCAGCAAAATGCCTGATGCGGTGGTGGCAATTGGCGGTGGCAGTACGCTTGACCTCGGTAAAGGCATTGCGCT
TTTAATGACGAACGATGTACCTGCATTGTCGCTAAAAGGCTTTCCAACAGGCGTGAACGATCCGCTGCCGCTTGTTACGG
TGCCAACCTTGCTGGGCAGTGGCGCTGAGGTTAGCTATAACGCAGTTTTTATTGATGAAGCCGAAGGGCGCAAGCTTGGC
ATTAACAGCCGTAAGAATTTTCCGAAAAAGTCGGTGATTGACCCTCAGCTCTCCATGACGGCGCCAATTGAGAGCGTGAT
TGCTTCGGCAATGGATAGCCTTGTGCATTGCGTTGATAGCTTTGGTTCTATTAAGCATACGCCACTGAGCCGTATTTTTT
CAATTGAAGGGTTCCAACGCACTTTTTATGCGTTGCAGCAAGATCAGCTCGATCGTGCTGAATCGCGCCTCGATTTGGCT
ATTGGTAGCATTTGCGGCGTGGTTGCGTTAATGAATTCGGGTGATGGTCCAACGAACGGTTTTGCCTACTATCTTGGCGT
TAAGCATCGTGTGCCGCATGGTTTAGCGGGCGCAATTTTCTTAAAAGAGGTGATGCGCTACAACCATAAAAATGGCTATG
AAAAATATGCGTTGCTGAACCCCATGCGCTCAACGCCATTAGCAAAAGAGGTTACGGCTGAGTTGTTGGAGGAAATGGAT
GCGTTGTACAAGCAGTTGCGGATTCCAAACCTTGTGCCATACGGTTATGGCAAGGGCAATGTGGATGAATTTGCTAAGAA
TGCGTCGGAAGCGTTGAAGGGTTCATTCTCCGGCAATCCCGTACCATTTACGCCCGAGTCGGCACGCGAGGTTATCTATC
AATTAACGTAA

Upstream 100 bases:

>100_bases
AAATTTTTATAAAGCTTACAATTAATACCAGCTAAAAATCAATCATTAAAACTTTATCTTCATTTCAAATTTTCATTGCA
AACTCAAAATCACCACATCC

Downstream 100 bases:

>100_bases
TTACCGATCCATAGAGACGCGATTAATCGCGTCTCTACGTGTTGGATGGGTGTGAAACGTAGGGTGGAATCCATTTTCAC
CCTGACGGAGAGTGGCGGAT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNFFLSTDLVIGVNEALKLNEHLSTMPIAKPAIIYDANVASSLYFQEVLKNLQAAFPNAVTYCNDFAGEPTYAHLENVAT
MFRSKMPDAVVAIGGGSTLDLGKGIALLMTNDVPALSLKGFPTGVNDPLPLVTVPTLLGSGAEVSYNAVFIDEAEGRKLG
INSRKNFPKKSVIDPQLSMTAPIESVIASAMDSLVHCVDSFGSIKHTPLSRIFSIEGFQRTFYALQQDQLDRAESRLDLA
IGSICGVVALMNSGDGPTNGFAYYLGVKHRVPHGLAGAIFLKEVMRYNHKNGYEKYALLNPMRSTPLAKEVTAELLEEMD
ALYKQLRIPNLVPYGYGKGNVDEFAKNASEALKGSFSGNPVPFTPESAREVIYQLT

Sequences:

>Translated_376_residues
MNFFLSTDLVIGVNEALKLNEHLSTMPIAKPAIIYDANVASSLYFQEVLKNLQAAFPNAVTYCNDFAGEPTYAHLENVAT
MFRSKMPDAVVAIGGGSTLDLGKGIALLMTNDVPALSLKGFPTGVNDPLPLVTVPTLLGSGAEVSYNAVFIDEAEGRKLG
INSRKNFPKKSVIDPQLSMTAPIESVIASAMDSLVHCVDSFGSIKHTPLSRIFSIEGFQRTFYALQQDQLDRAESRLDLA
IGSICGVVALMNSGDGPTNGFAYYLGVKHRVPHGLAGAIFLKEVMRYNHKNGYEKYALLNPMRSTPLAKEVTAELLEEMD
ALYKQLRIPNLVPYGYGKGNVDEFAKNASEALKGSFSGNPVPFTPESAREVIYQLT
>Mature_376_residues
MNFFLSTDLVIGVNEALKLNEHLSTMPIAKPAIIYDANVASSLYFQEVLKNLQAAFPNAVTYCNDFAGEPTYAHLENVAT
MFRSKMPDAVVAIGGGSTLDLGKGIALLMTNDVPALSLKGFPTGVNDPLPLVTVPTLLGSGAEVSYNAVFIDEAEGRKLG
INSRKNFPKKSVIDPQLSMTAPIESVIASAMDSLVHCVDSFGSIKHTPLSRIFSIEGFQRTFYALQQDQLDRAESRLDLA
IGSICGVVALMNSGDGPTNGFAYYLGVKHRVPHGLAGAIFLKEVMRYNHKNGYEKYALLNPMRSTPLAKEVTAELLEEMD
ALYKQLRIPNLVPYGYGKGNVDEFAKNASEALKGSFSGNPVPFTPESAREVIYQLT

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87082107, Length=237, Percent_Identity=27.0042194092827, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789163, Length=355, Percent_Identity=27.0422535211268, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994951, Length=301, Percent_Identity=27.2425249169435, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787493, Length=314, Percent_Identity=23.5668789808917, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537053, Length=318, Percent_Identity=25.1572327044025, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321181, Length=347, Percent_Identity=24.7838616714697, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40780; Mature: 40780

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFLSTDLVIGVNEALKLNEHLSTMPIAKPAIIYDANVASSLYFQEVLKNLQAAFPNAV
CCEEEECCEEEECHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHH
TYCNDFAGEPTYAHLENVATMFRSKMPDAVVAIGGGSTLDLGKGIALLMTNDVPALSLKG
HHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEECCCCEEEECC
FPTGVNDPLPLVTVPTLLGSGAEVSYNAVFIDEAEGRKLGINSRKNFPKKSVIDPQLSMT
CCCCCCCCCCCEEHHHHHCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCC
APIESVIASAMDSLVHCVDSFGSIKHTPLSRIFSIEGFQRTFYALQQDQLDRAESRLDLA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IGSICGVVALMNSGDGPTNGFAYYLGVKHRVPHGLAGAIFLKEVMRYNHKNGYEKYALLN
HHHHHHHHHHHCCCCCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHC
PMRSTPLAKEVTAELLEEMDALYKQLRIPNLVPYGYGKGNVDEFAKNASEALKGSFSGNP
CHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
VPFTPESAREVIYQLT
CCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNFFLSTDLVIGVNEALKLNEHLSTMPIAKPAIIYDANVASSLYFQEVLKNLQAAFPNAV
CCEEEECCEEEECHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHH
TYCNDFAGEPTYAHLENVATMFRSKMPDAVVAIGGGSTLDLGKGIALLMTNDVPALSLKG
HHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEECCCCEEEECC
FPTGVNDPLPLVTVPTLLGSGAEVSYNAVFIDEAEGRKLGINSRKNFPKKSVIDPQLSMT
CCCCCCCCCCCEEHHHHHCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCC
APIESVIASAMDSLVHCVDSFGSIKHTPLSRIFSIEGFQRTFYALQQDQLDRAESRLDLA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IGSICGVVALMNSGDGPTNGFAYYLGVKHRVPHGLAGAIFLKEVMRYNHKNGYEKYALLN
HHHHHHHHHHHCCCCCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHC
PMRSTPLAKEVTAELLEEMDALYKQLRIPNLVPYGYGKGNVDEFAKNASEALKGSFSGNP
CHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
VPFTPESAREVIYQLT
CCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]