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The map label for this gene is hldD [H]

Identifier: 78189051

GI number: 78189051

Start: 1466203

End: 1467183

Strand: Reverse

Name: hldD [H]

Synonym: Cag_1084

Alternate gene names: 78189051

Gene position: 1467183-1466203 (Counterclockwise)

Preceding gene: 78189052

Following gene: 78189050

Centisome position: 57.04

GC content: 48.11

Gene sequence:

>981_bases
ATGATAATTATTACCGGAGGCGCAGGCTTTATTGGCAGTGCTATGCTATGGGAACTTAACGCGCATGGCGAGGAAGATAT
TATTATTGTTGATGAGCTTGGCTCCACAACCACCCAGCAATGGCGCAACCTTTCAGGCTTACGCTACAGCGACTACATCC
ACAAAAACGACTTCATCCCTCTTTTAGAGCGCAACGCTTTAAAAGGGATTACAGCAATTATTCACATGGGGGCAAACAGC
TCCACCACTGAAACCGATGCCGACCATTTAATGAGCAACAACTTTGGCTACTCCAAAAGTATTGCAACCTACTGCATGGA
GCACCATATTCGGCTCATTTACGCCTCAAGCGCTGCAACTTACGGTGATGGTGCAAACGGGTACAGCGACGATAGTAATG
GCATTACAACCTTACGTCCGCTCAATATGTATGGCTACTCGAAGCAGCTTTTTGATTGGTGGGCGCTACAACAAGGTGTA
CTTAATTATGCCGTCGGCTTAAAGTTCTTTAATGTGTATGGACCGAATGAGTACCATAAAGGCGACATGAGCAGCGTGGT
GTATAAAGCCTTCCATCAAATCCATCAAAACGGAAGCGTTAAGCTCTTTCAATCGCATCGCCCCGATTATGGGCATGGTG
AACAATCGCGCGACTTTATTTACGTGCGCGATTGCACGGCAATTATGCTCTGGCTGTTAGAGCATCCCTTGGGTGGACTT
TTTAATGTGGGGAGCGGCGTTGCTCGAAGTTTTCGTGAATTGGTTACCGCAACCTTTGCCGCACTTGGCAAAGAGCCTGC
AATTGAGTACATCCCCATGCCCGAAACCCTGCGCGATAAATACCAATACTACACCTGCGCTACTATGGAAAAGCTCCGTC
AAGCAGGCTACACGGCACCCTTTACCTCGCTTGAAGAGGGCGTTCGTGACTACGTGCAAACCTATTTATCCGCCACCTCC
CCTTACCTTGGCAAAGGATGA

Upstream 100 bases:

>100_bases
CTTTTTTTGGAACATCTCCCTCGCTTTTTTTGTTTTTCCCTACAGGTGCGCTTATTTTGGCAGCAATAAGATTCCTTTTA
TTCCCCTCTATCCTACTTTT

Downstream 100 bases:

>100_bases
TAAATTTTCAATCACAATAACCTACTGTCGTGTCAAACTTATAATGAGGCAATTCGTCATTGCCGCAACGAAGTGAAGAA
TCCATTTTAAAATCCAGCAA

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MIIITGGAGFIGSAMLWELNAHGEEDIIIVDELGSTTTQQWRNLSGLRYSDYIHKNDFIPLLERNALKGITAIIHMGANS
STTETDADHLMSNNFGYSKSIATYCMEHHIRLIYASSAATYGDGANGYSDDSNGITTLRPLNMYGYSKQLFDWWALQQGV
LNYAVGLKFFNVYGPNEYHKGDMSSVVYKAFHQIHQNGSVKLFQSHRPDYGHGEQSRDFIYVRDCTAIMLWLLEHPLGGL
FNVGSGVARSFRELVTATFAALGKEPAIEYIPMPETLRDKYQYYTCATMEKLRQAGYTAPFTSLEEGVRDYVQTYLSATS
PYLGKG

Sequences:

>Translated_326_residues
MIIITGGAGFIGSAMLWELNAHGEEDIIIVDELGSTTTQQWRNLSGLRYSDYIHKNDFIPLLERNALKGITAIIHMGANS
STTETDADHLMSNNFGYSKSIATYCMEHHIRLIYASSAATYGDGANGYSDDSNGITTLRPLNMYGYSKQLFDWWALQQGV
LNYAVGLKFFNVYGPNEYHKGDMSSVVYKAFHQIHQNGSVKLFQSHRPDYGHGEQSRDFIYVRDCTAIMLWLLEHPLGGL
FNVGSGVARSFRELVTATFAALGKEPAIEYIPMPETLRDKYQYYTCATMEKLRQAGYTAPFTSLEEGVRDYVQTYLSATS
PYLGKG
>Mature_326_residues
MIIITGGAGFIGSAMLWELNAHGEEDIIIVDELGSTTTQQWRNLSGLRYSDYIHKNDFIPLLERNALKGITAIIHMGANS
STTETDADHLMSNNFGYSKSIATYCMEHHIRLIYASSAATYGDGANGYSDDSNGITTLRPLNMYGYSKQLFDWWALQQGV
LNYAVGLKFFNVYGPNEYHKGDMSSVVYKAFHQIHQNGSVKLFQSHRPDYGHGEQSRDFIYVRDCTAIMLWLLEHPLGGL
FNVGSGVARSFRELVTATFAALGKEPAIEYIPMPETLRDKYQYYTCATMEKLRQAGYTAPFTSLEEGVRDYVQTYLSATS
PYLGKG

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=317, Percent_Identity=44.4794952681388, Blast_Score=241, Evalue=5e-65,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36515; Mature: 36515

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIITGGAGFIGSAMLWELNAHGEEDIIIVDELGSTTTQQWRNLSGLRYSDYIHKNDFIP
CEEEECCCCHHCCCCEEEECCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHHHCCCCCCH
LLERNALKGITAIIHMGANSSTTETDADHLMSNNFGYSKSIATYCMEHHIRLIYASSAAT
HHHHHHHHHEEHHEEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCEEEEEECCCCC
YGDGANGYSDDSNGITTLRPLNMYGYSKQLFDWWALQQGVLNYAVGLKFFNVYGPNEYHK
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCC
GDMSSVVYKAFHQIHQNGSVKLFQSHRPDYGHGEQSRDFIYVRDCTAIMLWLLEHPLGGL
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCH
FNVGSGVARSFRELVTATFAALGKEPAIEYIPMPETLRDKYQYYTCATMEKLRQAGYTAP
HHCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
FTSLEEGVRDYVQTYLSATSPYLGKG
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIIITGGAGFIGSAMLWELNAHGEEDIIIVDELGSTTTQQWRNLSGLRYSDYIHKNDFIP
CEEEECCCCHHCCCCEEEECCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHHHCCCCCCH
LLERNALKGITAIIHMGANSSTTETDADHLMSNNFGYSKSIATYCMEHHIRLIYASSAAT
HHHHHHHHHEEHHEEECCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCEEEEEECCCCC
YGDGANGYSDDSNGITTLRPLNMYGYSKQLFDWWALQQGVLNYAVGLKFFNVYGPNEYHK
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCC
GDMSSVVYKAFHQIHQNGSVKLFQSHRPDYGHGEQSRDFIYVRDCTAIMLWLLEHPLGGL
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCH
FNVGSGVARSFRELVTATFAALGKEPAIEYIPMPETLRDKYQYYTCATMEKLRQAGYTAP
HHCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
FTSLEEGVRDYVQTYLSATSPYLGKG
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA