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The map label for this gene is msrAB [H]

Identifier: 78188928

GI number: 78188928

Start: 1298841

End: 1299704

Strand: Reverse

Name: msrAB [H]

Synonym: Cag_0960

Alternate gene names: 78188928

Gene position: 1299704-1298841 (Counterclockwise)

Preceding gene: 78188929

Following gene: 78188927

Centisome position: 50.53

GC content: 47.22

Gene sequence:

>864_bases
ATGCAATACAACCATTTAACACCCGATGAAGAGCGGGTTATGCTTCATAAAGGCACAGAGCTTCCCTTTAGCGGAATTTA
CTACGACCATCACGATAGTGGTACCTACCATTGTCGCCGTTGCAATACAGCGCTTTTTCATTCCGACAATAAATTTAATT
CAGGCACAGGTTGGCCCAGCTTTGATGATGCCATTGAGGGTGCTGTCCGTCAGATTCCTGATGCCGATGGGCGTCGTACC
GAAATTGTGTGTGCTAACTGTGGTGCCCATTTGGGGCATGTTTTTTTTCGGGAAGGCTTCACCACTAAAAATGTTCGCCA
TTGCGTGAACTCCATTTCATTGAACTTTCAGCCCCAAGCAACTCAAGCTACCATACCCACCACAACGCAAACAGCCGTAT
TTGCGGGTGGATGTTTTTGGGGAGTGGAATACCATTTTAGCAAGCTAAAAGGGGTGCTTTCTGTTACTTCAGGTTATACG
GGAGGTGCCATTGAAAACCCCACCTATCAGCAAGTGTGCAGCGGTAAAACAGGTCATGCTGAAGCCGTCGAAATTGTTTT
TGATGCCGCCCAAGTGTCGTATGAAACGTTGGCAAAGCTCTTTTTTGAAATTCACGATCCTACGCAAGTGAATCGCCAAG
GTCCCGACGTTGGTACGCAATATCGCTCGGCACTTTTTTATGCTAACGAGGAGCAGCGCCGCATTGCAGAAAAGCTTATT
GGCGAGTTACAAGCTAAAGGCTATCGGGTAGCCACAAGTGTTGAACCAGCATCCCAGTTTTGGGCAGCCGAAGCATATCA
TCAAGAGTATTATGCACGGCATGGGCATGAGCCATATTGCCACGTTTACACCAAACGCTTTTAA

Upstream 100 bases:

>100_bases
CTCCATTTTTTTGCAATACAGCCTCTTTGTGTTTGCCTTTCTCATGCTGATGGCTTGCCAAAAAAGTGTTCACCAATCCC
AACCCCAACCCCAACCATCT

Downstream 100 bases:

>100_bases
GGTGCTTAATTTTTTCCATGAGCACCGAAACTTACAGCGTTAAAGGAATGCACTGTGCAAGTTGCGCAGCCATTATTGAA
AAAAAGCTCTCTAAAGTAGA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MQYNHLTPDEERVMLHKGTELPFSGIYYDHHDSGTYHCRRCNTALFHSDNKFNSGTGWPSFDDAIEGAVRQIPDADGRRT
EIVCANCGAHLGHVFFREGFTTKNVRHCVNSISLNFQPQATQATIPTTTQTAVFAGGCFWGVEYHFSKLKGVLSVTSGYT
GGAIENPTYQQVCSGKTGHAEAVEIVFDAAQVSYETLAKLFFEIHDPTQVNRQGPDVGTQYRSALFYANEEQRRIAEKLI
GELQAKGYRVATSVEPASQFWAAEAYHQEYYARHGHEPYCHVYTKRF

Sequences:

>Translated_287_residues
MQYNHLTPDEERVMLHKGTELPFSGIYYDHHDSGTYHCRRCNTALFHSDNKFNSGTGWPSFDDAIEGAVRQIPDADGRRT
EIVCANCGAHLGHVFFREGFTTKNVRHCVNSISLNFQPQATQATIPTTTQTAVFAGGCFWGVEYHFSKLKGVLSVTSGYT
GGAIENPTYQQVCSGKTGHAEAVEIVFDAAQVSYETLAKLFFEIHDPTQVNRQGPDVGTQYRSALFYANEEQRRIAEKLI
GELQAKGYRVATSVEPASQFWAAEAYHQEYYARHGHEPYCHVYTKRF
>Mature_287_residues
MQYNHLTPDEERVMLHKGTELPFSGIYYDHHDSGTYHCRRCNTALFHSDNKFNSGTGWPSFDDAIEGAVRQIPDADGRRT
EIVCANCGAHLGHVFFREGFTTKNVRHCVNSISLNFQPQATQATIPTTTQTAVFAGGCFWGVEYHFSKLKGVLSVTSGYT
GGAIENPTYQQVCSGKTGHAEAVEIVFDAAQVSYETLAKLFFEIHDPTQVNRQGPDVGTQYRSALFYANEEQRRIAEKLI
GELQAKGYRVATSVEPASQFWAAEAYHQEYYARHGHEPYCHVYTKRF

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=45.2830188679245, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=45.2830188679245, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI117606353, Length=124, Percent_Identity=45.1612903225806, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI301336164, Length=122, Percent_Identity=43.4426229508197, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI301336162, Length=122, Percent_Identity=43.4426229508197, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI73089054, Length=122, Percent_Identity=43.4426229508197, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=42.741935483871, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI208609993, Length=104, Percent_Identity=41.3461538461538, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790665, Length=170, Percent_Identity=45.2941176470588, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1788077, Length=107, Percent_Identity=46.7289719626168, Blast_Score=91, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=35.8620689655172, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=123, Percent_Identity=38.2113821138211, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115532676, Length=123, Percent_Identity=38.2113821138211, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=36.0759493670886, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=43.3333333333333, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221378664, Length=131, Percent_Identity=40.4580152671756, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45553335, Length=132, Percent_Identity=40.9090909090909, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356369, Length=132, Percent_Identity=40.9090909090909, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24645799, Length=134, Percent_Identity=40.2985074626866, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221378662, Length=138, Percent_Identity=38.4057971014493, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645804, Length=143, Percent_Identity=37.7622377622378, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645801, Length=144, Percent_Identity=37.5, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664627, Length=151, Percent_Identity=34.4370860927152, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664631, Length=151, Percent_Identity=33.7748344370861, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=34.5323741007194, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 32266; Mature: 32266

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYNHLTPDEERVMLHKGTELPFSGIYYDHHDSGTYHCRRCNTALFHSDNKFNSGTGWPS
CCCCCCCCCHHEEEEECCCCCCCCCEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCCC
FDDAIEGAVRQIPDADGRRTEIVCANCGAHLGHVFFREGFTTKNVRHCVNSISLNFQPQA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
TQATIPTTTQTAVFAGGCFWGVEYHFSKLKGVLSVTSGYTGGAIENPTYQQVCSGKTGHA
CCCCCCCCCCHHEEECCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCH
EAVEIVFDAAQVSYETLAKLFFEIHDPTQVNRQGPDVGTQYRSALFYANEEQRRIAEKLI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEEECCHHHHHHHHHHH
GELQAKGYRVATSVEPASQFWAAEAYHQEYYARHGHEPYCHVYTKRF
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure
MQYNHLTPDEERVMLHKGTELPFSGIYYDHHDSGTYHCRRCNTALFHSDNKFNSGTGWPS
CCCCCCCCCHHEEEEECCCCCCCCCEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCCC
FDDAIEGAVRQIPDADGRRTEIVCANCGAHLGHVFFREGFTTKNVRHCVNSISLNFQPQA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
TQATIPTTTQTAVFAGGCFWGVEYHFSKLKGVLSVTSGYTGGAIENPTYQQVCSGKTGHA
CCCCCCCCCCHHEEECCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCH
EAVEIVFDAAQVSYETLAKLFFEIHDPTQVNRQGPDVGTQYRSALFYANEEQRRIAEKLI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEEECCHHHHHHHHHHH
GELQAKGYRVATSVEPASQFWAAEAYHQEYYARHGHEPYCHVYTKRF
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]