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The map label for this gene is menA [H]

Identifier: 78188911

GI number: 78188911

Start: 1279243

End: 1280139

Strand: Reverse

Name: menA [H]

Synonym: Cag_0943

Alternate gene names: 78188911

Gene position: 1280139-1279243 (Counterclockwise)

Preceding gene: 78188912

Following gene: 78188910

Centisome position: 49.77

GC content: 49.28

Gene sequence:

>897_bases
ATGGGTAATGAGCACCCAACACCATCGCTTGTGCAAGCATGGATGCTTGCCATTCGTCCAAAAACCTTGCCCGCAGGAGC
TGTGCCCGTAGTGCTCGGCTCAGCGCTTGCGGCGGTACATGGCTCCTTTAAGCCATTACCTGCATTGGTTGCCTTGCTTT
GTGCGCTTGGCATTCAAGTAGCCACCAACTTTATTAACGAAATTTACGACTTCCGTAAAGGTGCCGATACGGCTGAGCGG
CTTGGTCCCACGCGCACGGTAGCCGCAGGGCTTATTAGCGAAGCCACCATGATTCGTGTATCGGCACTGCTTGTGGGCAC
CGTTTTTTGCATGGGCATGTATCTCGTTTTTATTGCAGGATGGCAAATTTTACTGATTGGGCTGCTTTCACTGCTTTTTG
CATGGGCTTATACGGGCGGACCTTACCCAATTGCCTATTCAGGGCTTGGTGATCTTTTTGTTTTTATTTTTTTTGGATTG
GTTGCAGTGGGTGGAACATACTATGTGCAAACGCTTGAAGTGAGTTTTCCCATATTGCTTGCTGCCGCTGCTCCCGGTGC
TTTTTCGGTTGATATTTTGTTAGTCAACAACATCCGCGATATTACCACGGATCGCAAAGTTGGCAAAATGACTTTGCCCG
CTCGCATTGGTGCCGAATGGGCGCGTCGCTTGTACGTATTGCTGATGATTATCGCTTTTGCTGTACCAATTGTATTAACG
GGATTTGGCTATTCACCATGGGGAATGTTGTCGTTTGCGGCATTACCAGCGGCAGTGCGCTCGGTTAAGCAGCTCTACCA
AAGCGAAGGGCGTGAATTAAATCAGGTGTTAGCGGGTACAGGTCAAGTGATGACGTTGCACGGTATGTTGCTATCCATCG
GATTGTTGGTGCCTTAA

Upstream 100 bases:

>100_bases
GCAGTGCGCCATAGCTTGCACTACATTAAACCGGGTGAAAAAATTAAGCACACCTTTAGCAGTGTAAAAATGGCGAAGGA
GAAGAAAAAGGGGATGCAGA

Downstream 100 bases:

>100_bases
GGGCATCTTTAAAAATTGAGTTATAGACAAATGAGCAAAGAATCTGTTTCAATTGCTGTGGTGCAAAGCGAGTGCAAGGG
CGACGCAGTAGCAAACCGTG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGNEHPTPSLVQAWMLAIRPKTLPAGAVPVVLGSALAAVHGSFKPLPALVALLCALGIQVATNFINEIYDFRKGADTAER
LGPTRTVAAGLISEATMIRVSALLVGTVFCMGMYLVFIAGWQILLIGLLSLLFAWAYTGGPYPIAYSGLGDLFVFIFFGL
VAVGGTYYVQTLEVSFPILLAAAAPGAFSVDILLVNNIRDITTDRKVGKMTLPARIGAEWARRLYVLLMIIAFAVPIVLT
GFGYSPWGMLSFAALPAAVRSVKQLYQSEGRELNQVLAGTGQVMTLHGMLLSIGLLVP

Sequences:

>Translated_298_residues
MGNEHPTPSLVQAWMLAIRPKTLPAGAVPVVLGSALAAVHGSFKPLPALVALLCALGIQVATNFINEIYDFRKGADTAER
LGPTRTVAAGLISEATMIRVSALLVGTVFCMGMYLVFIAGWQILLIGLLSLLFAWAYTGGPYPIAYSGLGDLFVFIFFGL
VAVGGTYYVQTLEVSFPILLAAAAPGAFSVDILLVNNIRDITTDRKVGKMTLPARIGAEWARRLYVLLMIIAFAVPIVLT
GFGYSPWGMLSFAALPAAVRSVKQLYQSEGRELNQVLAGTGQVMTLHGMLLSIGLLVP
>Mature_297_residues
GNEHPTPSLVQAWMLAIRPKTLPAGAVPVVLGSALAAVHGSFKPLPALVALLCALGIQVATNFINEIYDFRKGADTAERL
GPTRTVAAGLISEATMIRVSALLVGTVFCMGMYLVFIAGWQILLIGLLSLLFAWAYTGGPYPIAYSGLGDLFVFIFFGLV
AVGGTYYVQTLEVSFPILLAAAAPGAFSVDILLVNNIRDITTDRKVGKMTLPARIGAEWARRLYVLLMIIAFAVPIVLTG
FGYSPWGMLSFAALPAAVRSVKQLYQSEGRELNQVLAGTGQVMTLHGMLLSIGLLVP

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=229, Percent_Identity=33.6244541484716, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1790365, Length=291, Percent_Identity=35.0515463917526, Blast_Score=156, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17737429, Length=281, Percent_Identity=28.4697508896797, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31743; Mature: 31612

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNEHPTPSLVQAWMLAIRPKTLPAGAVPVVLGSALAAVHGSFKPLPALVALLCALGIQV
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ATNFINEIYDFRKGADTAERLGPTRTVAAGLISEATMIRVSALLVGTVFCMGMYLVFIAG
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQILLIGLLSLLFAWAYTGGPYPIAYSGLGDLFVFIFFGLVAVGGTYYVQTLEVSFPILL
HHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCHHEEEEEHHHHHHHH
AAAAPGAFSVDILLVNNIRDITTDRKVGKMTLPARIGAEWARRLYVLLMIIAFAVPIVLT
EECCCCCEEEEEEEECCCHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFGYSPWGMLSFAALPAAVRSVKQLYQSEGRELNQVLAGTGQVMTLHGMLLSIGLLVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GNEHPTPSLVQAWMLAIRPKTLPAGAVPVVLGSALAAVHGSFKPLPALVALLCALGIQV
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ATNFINEIYDFRKGADTAERLGPTRTVAAGLISEATMIRVSALLVGTVFCMGMYLVFIAG
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQILLIGLLSLLFAWAYTGGPYPIAYSGLGDLFVFIFFGLVAVGGTYYVQTLEVSFPILL
HHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCHHEEEEEHHHHHHHH
AAAAPGAFSVDILLVNNIRDITTDRKVGKMTLPARIGAEWARRLYVLLMIIAFAVPIVLT
EECCCCCEEEEEEEECCCHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFGYSPWGMLSFAALPAAVRSVKQLYQSEGRELNQVLAGTGQVMTLHGMLLSIGLLVP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]