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The map label for this gene is argH

Identifier: 78188706

GI number: 78188706

Start: 1007315

End: 1008700

Strand: Reverse

Name: argH

Synonym: Cag_0730

Alternate gene names: 78188706

Gene position: 1008700-1007315 (Counterclockwise)

Preceding gene: 78188707

Following gene: 78188704

Centisome position: 39.22

GC content: 46.18

Gene sequence:

>1386_bases
ATGAGCAGCAAGAATAAGGAGTTATTGTGGCAAAGCCGTTTTTCACTACCGTTTGATAGAGATGCCTTGCGTTTTTCTTC
CTCAGTACATGTGGATAAAGCGCTGTATCGCGAAGATATTCAAGGCTCTATTGCCCATGTTACCATGTTAGCCGAGCAAC
AGATTGTAAGCCACGAGGAGGCTCAGGCAATTATTGCGGGATTACAAGAAATTGAGCTTGAGCTAAGAGATGGCAACATA
GTGCCTCATTGGGAGGATGAGGATATTCATACAGTTATTGAAAATCGTTTAAAGGAAAAAATTGGAGCGGTTGCGGGTAA
GCTCCATTCGGGGAGAAGTCGTAACGACCAAGTGGCAACCGATACGCGCCTTTACTTGCGGCGCAACATTGGCAGCTTGC
AAGCTGCGCTTAGTGAGTTGCTTACTGTTTTGCTTCAAAAAGCTGAGCACTATTGCGACACTATTATTTTTGGTTACACC
CACCTTCAGCGGGCACAACCCATTTCGGCAGGGCATTACTACATGGCATATTTTACCATGTTTTTGCGCGATCGTGATCG
TTTGCAGGATTTACTGAAGCGCGTGAACATTTCCCCGCTTGGTGCGGCGGCGTTTGCGGGCAGCACCTTGCCGCTTAATC
CTGCGCGTTCGGCGGAGTTGCTTGGCTTTGAGGGCATCTTTAGCAACAGCATTGACGCGGTGAGCGATCGCGATATTCTT
ATTGAGTTTCTTTCAGATTGCGCTATGGTGATGATGCACCTTTCGCGTTTTGCTGAGGATGTGATTTTATGGAGCTCGTA
TGAGTTTGGCTACCTTGAAATTAGCGATGCTTTTGCAACGGGATCGTCGCTGATGCCGCAAAAGAAAAATGCTGATATTG
CGGAGCTTGTGCGCGGCAAAGCGGGGCGTGTGTATGGTAACTTGATGGCAATGCTTACCATTATGAAGGGATTGCCGCTC
TCTTACAATCGCGACATGCAGGAAGATAAGCAACCGCTTTTTGATAGCACTGAAACGGCTATCAACAGCGTTACTATTTT
TTCTAAAATGTTAGAAAATACGCGCTTAAAAGAAGAGCGCTTAGCAAAACTCACTTCGGAGGATTTAAGCCTTGCCACTG
AAATTGCGGAATACTTAGTGCAGAAGCACATCCCGTTTCGTGATGCTCACCGTATTACAGGTAAAATTGTATCGTGGAGT
ATTGAGTCAGGCGTAGCACTTCCCCACATTCCGCTTGAGCAGTTTAAAAGCTTTGCGGCTGAGTTTGATGAAGGGATTTA
TGCTTGCTTAAAAGCCGATGCAAGTGTTCGAGCGAAAAAAACACACGGCAGTTGCTCGTTTGAATCGGTCAAGCAGCAAA
TTAATGCCGCAAAAGAGAGGATTTAA

Upstream 100 bases:

>100_bases
AGAGGCGTTTTATTGATGGTGGAGAGTAGCAACTCTTTTTCTATTTTGCGGCACATTTTTAATCCCTCCCCCAAATTTTA
CAATCTGCAATTTATACGCT

Downstream 100 bases:

>100_bases
GAATAGAATGAAGCCAAAAGGAGAGTTGACAAGAATGTCCGCTCTCCTTGTAGAAACTCCTTTAATTCAACGCGGGCACC
GCACGAATAACCGTTTGGCG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSSKNKELLWQSRFSLPFDRDALRFSSSVHVDKALYREDIQGSIAHVTMLAEQQIVSHEEAQAIIAGLQEIELELRDGNI
VPHWEDEDIHTVIENRLKEKIGAVAGKLHSGRSRNDQVATDTRLYLRRNIGSLQAALSELLTVLLQKAEHYCDTIIFGYT
HLQRAQPISAGHYYMAYFTMFLRDRDRLQDLLKRVNISPLGAAAFAGSTLPLNPARSAELLGFEGIFSNSIDAVSDRDIL
IEFLSDCAMVMMHLSRFAEDVILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGKAGRVYGNLMAMLTIMKGLPL
SYNRDMQEDKQPLFDSTETAINSVTIFSKMLENTRLKEERLAKLTSEDLSLATEIAEYLVQKHIPFRDAHRITGKIVSWS
IESGVALPHIPLEQFKSFAAEFDEGIYACLKADASVRAKKTHGSCSFESVKQQINAAKERI

Sequences:

>Translated_461_residues
MSSKNKELLWQSRFSLPFDRDALRFSSSVHVDKALYREDIQGSIAHVTMLAEQQIVSHEEAQAIIAGLQEIELELRDGNI
VPHWEDEDIHTVIENRLKEKIGAVAGKLHSGRSRNDQVATDTRLYLRRNIGSLQAALSELLTVLLQKAEHYCDTIIFGYT
HLQRAQPISAGHYYMAYFTMFLRDRDRLQDLLKRVNISPLGAAAFAGSTLPLNPARSAELLGFEGIFSNSIDAVSDRDIL
IEFLSDCAMVMMHLSRFAEDVILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGKAGRVYGNLMAMLTIMKGLPL
SYNRDMQEDKQPLFDSTETAINSVTIFSKMLENTRLKEERLAKLTSEDLSLATEIAEYLVQKHIPFRDAHRITGKIVSWS
IESGVALPHIPLEQFKSFAAEFDEGIYACLKADASVRAKKTHGSCSFESVKQQINAAKERI
>Mature_460_residues
SSKNKELLWQSRFSLPFDRDALRFSSSVHVDKALYREDIQGSIAHVTMLAEQQIVSHEEAQAIIAGLQEIELELRDGNIV
PHWEDEDIHTVIENRLKEKIGAVAGKLHSGRSRNDQVATDTRLYLRRNIGSLQAALSELLTVLLQKAEHYCDTIIFGYTH
LQRAQPISAGHYYMAYFTMFLRDRDRLQDLLKRVNISPLGAAAFAGSTLPLNPARSAELLGFEGIFSNSIDAVSDRDILI
EFLSDCAMVMMHLSRFAEDVILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGKAGRVYGNLMAMLTIMKGLPLS
YNRDMQEDKQPLFDSTETAINSVTIFSKMLENTRLKEERLAKLTSEDLSLATEIAEYLVQKHIPFRDAHRITGKIVSWSI
ESGVALPHIPLEQFKSFAAEFDEGIYACLKADASVRAKKTHGSCSFESVKQQINAAKERI

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=450, Percent_Identity=40.2222222222222, Blast_Score=344, Evalue=8e-95,
Organism=Homo sapiens, GI68303542, Length=450, Percent_Identity=40.2222222222222, Blast_Score=344, Evalue=8e-95,
Organism=Homo sapiens, GI68303547, Length=450, Percent_Identity=38.2222222222222, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI68303549, Length=450, Percent_Identity=38, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=40.6593406593407, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17553882, Length=338, Percent_Identity=26.3313609467456, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI32565146, Length=305, Percent_Identity=26.8852459016393, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=40.2597402597403, Blast_Score=350, Evalue=3e-97,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=36.1419068736142, Blast_Score=307, Evalue=8e-84,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=36.1419068736142, Blast_Score=307, Evalue=8e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CHLCH (Q3ASM4)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_379044.1
- ProteinModelPortal:   Q3ASM4
- SMR:   Q3ASM4
- STRING:   Q3ASM4
- GeneID:   3747426
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0730
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   CCHL340177:CAG_0730-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51842; Mature: 51711

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKNKELLWQSRFSLPFDRDALRFSSSVHVDKALYREDIQGSIAHVTMLAEQQIVSHEE
CCCCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AQAIIAGLQEIELELRDGNIVPHWEDEDIHTVIENRLKEKIGAVAGKLHSGRSRNDQVAT
HHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DTRLYLRRNIGSLQAALSELLTVLLQKAEHYCDTIIFGYTHLQRAQPISAGHYYMAYFTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FLRDRDRLQDLLKRVNISPLGAAAFAGSTLPLNPARSAELLGFEGIFSNSIDAVSDRDIL
HHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHCCCCHHCCCCCCCCCHHHH
IEFLSDCAMVMMHLSRFAEDVILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCCC
AGRVYGNLMAMLTIMKGLPLSYNRDMQEDKQPLFDSTETAINSVTIFSKMLENTRLKEER
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
LAKLTSEDLSLATEIAEYLVQKHIPFRDAHRITGKIVSWSIESGVALPHIPLEQFKSFAA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHH
EFDEGIYACLKADASVRAKKTHGSCSFESVKQQINAAKERI
HHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKNKELLWQSRFSLPFDRDALRFSSSVHVDKALYREDIQGSIAHVTMLAEQQIVSHEE
CCCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AQAIIAGLQEIELELRDGNIVPHWEDEDIHTVIENRLKEKIGAVAGKLHSGRSRNDQVAT
HHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DTRLYLRRNIGSLQAALSELLTVLLQKAEHYCDTIIFGYTHLQRAQPISAGHYYMAYFTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FLRDRDRLQDLLKRVNISPLGAAAFAGSTLPLNPARSAELLGFEGIFSNSIDAVSDRDIL
HHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHCCCCHHCCCCCCCCCHHHH
IEFLSDCAMVMMHLSRFAEDVILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCCC
AGRVYGNLMAMLTIMKGLPLSYNRDMQEDKQPLFDSTETAINSVTIFSKMLENTRLKEER
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
LAKLTSEDLSLATEIAEYLVQKHIPFRDAHRITGKIVSWSIESGVALPHIPLEQFKSFAA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHH
EFDEGIYACLKADASVRAKKTHGSCSFESVKQQINAAKERI
HHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA