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The map label for this gene is fba [H]

Identifier: 78188704

GI number: 78188704

Start: 1003884

End: 1004858

Strand: Reverse

Name: fba [H]

Synonym: Cag_0728

Alternate gene names: 78188704

Gene position: 1004858-1003884 (Counterclockwise)

Preceding gene: 78188706

Following gene: 78188703

Centisome position: 39.07

GC content: 45.23

Gene sequence:

>975_bases
ATGCAAAAGAAAAAAATCAGTTATAAAGAACTTGGATTAGTCAACAGCCGCGAAATGTTTAGCAAAGCGGTGGCTGGCGG
CTACGCTATTCCAGCTTATAACTTCAACAACCTTGAACAAATGCAGGCAATTATTCAAGCCTGTGTTGAAACCCAATCGC
CTGTTATTTTGCAGGTTTCAAAAGGTGCTCGGAGTTACGCTAATGAAACCCTCCTTCGTTACCTTGCTCAAGGCGCTGTA
GCATATGCTGAAGAGCTTGGTTCATCTATTCCCATTGTGCTGCACCTTGACCACGGCGATAGCCTTGAGCTTTGCAAAGA
TTGCATTGATTCGGGTTTCTCTTCAGTTATGATTGATGGTTCACACCTTTCTTATGAAGAAAATGTTGCGCTCACCAAAC
AGGTGGTGGAATATGCCCATCAGTACGATGTTACCGTTGAGGGTGAACTTGGCGTGTTAGCAGGTATTGAGGATGAAGTG
TCGGCAACGCACCACACCTACACACAACCTGAAGAGGTTGAGGATTTTGTGGCTAAAACTGGGGTGGATAGCCTTGCTAT
TTCCATTGGCACTTCGCACGGTGCTTTTAAGTTTAAGCCAGGTGAAGATCCAAAAATTCGCCTCGATATTCTTGCTGAAA
TTGAAAAGCGTATTCCGGGCTTCCCCATTGTGCTGCATGGCTCCTCGTCAGTGCCGCAGGATTTAGTGGCAACCATTAAC
CAAAATGGTGGCAAGTTGAAAGATGCTATTGGTATTAGCGAAGAACAATTGCGCCTTGCTGCAAAGTCAGCCGTCTGCAA
AATTAACATTGACTCCGATGGTCGCCTTGCCATGACGGCAGCTATCCGTAAAGTGCTTGCCGAAAAGCCTGAAGAGTTTG
ATCCTCGCAAATATCTTGGACCAGCTCGCGATAGCCTTAAAAAGATTTACATCCACAAAAATATTAATGTGTTGGGCTCA
AACGGCAAAGCGTAA

Upstream 100 bases:

>100_bases
TTAGAGATGCTTGTTTGAATGAGCAAGCGATATCCCTATATTTGCTGCCACGCATTTACAATGGCGGACGCTATAATACT
AAATAAACGGAGAGCTTTCA

Downstream 100 bases:

>100_bases
GCTCCAAACGCATTGATCAAAAGAAAGGGCACCTCTAAAAATCGTCGAGAGCGCTTGGATAACGAGGCGGACGGAGCGCA
AAAACCGGAGTGTACAGATA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQKKKISYKELGLVNSREMFSKAVAGGYAIPAYNFNNLEQMQAIIQACVETQSPVILQVSKGARSYANETLLRYLAQGAV
AYAEELGSSIPIVLHLDHGDSLELCKDCIDSGFSSVMIDGSHLSYEENVALTKQVVEYAHQYDVTVEGELGVLAGIEDEV
SATHHTYTQPEEVEDFVAKTGVDSLAISIGTSHGAFKFKPGEDPKIRLDILAEIEKRIPGFPIVLHGSSSVPQDLVATIN
QNGGKLKDAIGISEEQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLAEKPEEFDPRKYLGPARDSLKKIYIHKNINVLGS
NGKA

Sequences:

>Translated_324_residues
MQKKKISYKELGLVNSREMFSKAVAGGYAIPAYNFNNLEQMQAIIQACVETQSPVILQVSKGARSYANETLLRYLAQGAV
AYAEELGSSIPIVLHLDHGDSLELCKDCIDSGFSSVMIDGSHLSYEENVALTKQVVEYAHQYDVTVEGELGVLAGIEDEV
SATHHTYTQPEEVEDFVAKTGVDSLAISIGTSHGAFKFKPGEDPKIRLDILAEIEKRIPGFPIVLHGSSSVPQDLVATIN
QNGGKLKDAIGISEEQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLAEKPEEFDPRKYLGPARDSLKKIYIHKNINVLGS
NGKA
>Mature_324_residues
MQKKKISYKELGLVNSREMFSKAVAGGYAIPAYNFNNLEQMQAIIQACVETQSPVILQVSKGARSYANETLLRYLAQGAV
AYAEELGSSIPIVLHLDHGDSLELCKDCIDSGFSSVMIDGSHLSYEENVALTKQVVEYAHQYDVTVEGELGVLAGIEDEV
SATHHTYTQPEEVEDFVAKTGVDSLAISIGTSHGAFKFKPGEDPKIRLDILAEIEKRIPGFPIVLHGSSSVPQDLVATIN
QNGGKLKDAIGISEEQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLAEKPEEFDPRKYLGPARDSLKKIYIHKNINVLGS
NGKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=316, Percent_Identity=35.7594936708861, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87082041, Length=315, Percent_Identity=33.6507936507937, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1788072, Length=315, Percent_Identity=29.2063492063492, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789293, Length=307, Percent_Identity=26.3843648208469, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322790, Length=341, Percent_Identity=26.3929618768328, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 35217; Mature: 35217

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKKISYKELGLVNSREMFSKAVAGGYAIPAYNFNNLEQMQAIIQACVETQSPVILQVS
CCCCCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
KGARSYANETLLRYLAQGAVAYAEELGSSIPIVLHLDHGDSLELCKDCIDSGFSSVMIDG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEC
SHLSYEENVALTKQVVEYAHQYDVTVEGELGVLAGIEDEVSATHHTYTQPEEVEDFVAKT
CCCCCHHHHHHHHHHHHHHHHCCCEECCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHC
GVDSLAISIGTSHGAFKFKPGEDPKIRLDILAEIEKRIPGFPIVLHGSSSVPQDLVATIN
CCCCEEEEEECCCCEEEECCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHC
QNGGKLKDAIGISEEQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLAEKPEEFDPRKYLG
CCCCEEHHHHCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCC
PARDSLKKIYIHKNINVLGSNGKA
HHHHHHEEEEEEECCEEECCCCCC
>Mature Secondary Structure
MQKKKISYKELGLVNSREMFSKAVAGGYAIPAYNFNNLEQMQAIIQACVETQSPVILQVS
CCCCCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
KGARSYANETLLRYLAQGAVAYAEELGSSIPIVLHLDHGDSLELCKDCIDSGFSSVMIDG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEC
SHLSYEENVALTKQVVEYAHQYDVTVEGELGVLAGIEDEVSATHHTYTQPEEVEDFVAKT
CCCCCHHHHHHHHHHHHHHHHCCCEECCCCCEEECCCHHHHHCCCCCCCHHHHHHHHHHC
GVDSLAISIGTSHGAFKFKPGEDPKIRLDILAEIEKRIPGFPIVLHGSSSVPQDLVATIN
CCCCEEEEEECCCCEEEECCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHC
QNGGKLKDAIGISEEQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLAEKPEEFDPRKYLG
CCCCEEHHHHCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCC
PARDSLKKIYIHKNINVLGSNGKA
HHHHHHEEEEEEECCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]