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The map label for this gene is tetA [H]

Identifier: 78188701

GI number: 78188701

Start: 1000962

End: 1002215

Strand: Reverse

Name: tetA [H]

Synonym: Cag_0725

Alternate gene names: 78188701

Gene position: 1002215-1000962 (Counterclockwise)

Preceding gene: 78188702

Following gene: 78188700

Centisome position: 38.97

GC content: 41.95

Gene sequence:

>1254_bases
ATGAAGCGCTCTCCCCTATTTATTCTTCTCCTAACGGTTTTGCTTGATTTAATTGGCTTTGGCATTGTTTTGCCACTTTT
GCCAACTTATACCAAATCGCTTGGCGCCAACCCATTTATGATTGGGTTAATTGCCGCCATTTTTTCCATCATGCAGTTTA
TTTTTTCACCGCTGTGGGGCAAGTTAAGCGATAAAATTGGGCGACGCCCCGTCATGCTTTCCAGCATTTTACTGACGTCG
CTCTCATACCTCATGTTTGCTCAAGCCACCACATTGCCGCTCTTAATTCTTGCAAGAGCGCTTGCGGGCGTTGGTTCGGC
AAACGTTTCGGCAGCACAAGCTTACATTACCGATGTTACTGATGCTAAAGGACGTTCGGGCGCTATGGGCATGATGGGAG
CAGCGTTTGGTATTGGCTTTATTGTAGGACCTCTGCTGGGTGGCGTATTGATGCACAATTATGGCATTGCTGTTGTTGGC
TATGTAGCATCGTTACTCATTGCTATTGATTTTATTTTAGCAATTTTCTTTTTGCCTGAATCCAACAAAGCCGCAATTCC
TTTTACTCACTTATTGAAAGGAAATGAAAATAAAGGCACTCGTCACGGCAAAAAGCAATCATTAGGAACAACGCTTGCCA
CCAAAGTGCAAGAATATAACGAACACTTCCGTACAACCTTTTCGTCTCGCCCTTTAGCGCTATTGATGGTGGCAAATTTT
ATTTACACGCTCGCCATCGTCAACATGCAAACTGCCTCCATTCTTTTATGGAAAGAGTATTTTAAAGCCTCAGATGAACA
AATTGGCTATTTATTTGCTTACGTAGGAATTTGGTCAGTAGTCGTACAAGGTGGCTTAATTGGTAAATTGACTAAAAAAG
TTGGAGAGCATAATATTTTTCTATGGGGGCATCTCTTTACTTTTTTCGGTGTCTTTTTTATGCCCTTTTTGCCATCCTAT
TCCCTTTTTAGCATGGGGTTAACCGTCCTTTTCTTTTTTGCTATTGGCACCAGTTTAGTAGCCCCAATTAACCTTTCAAT
GATTTCGCTTTATAGCTACAATCAGCAACAAGGGCAAATTATGGGATTATCGCAATCGGTAAACGCATTTGCTCGCATTT
TAGGACCATTTAGCGGAAGCATTTTGTACGGAATGAGTTTTCATGCACCATACATTGTAGCTGGCATATTAACACTCGTT
GGTGCAGTTATTGCCTTGCGCTTGTTCCGTTATCGCATTGAAGCACACGATTAA

Upstream 100 bases:

>100_bases
TTTATCTTGACGCCATTACTGCCATAGCCTCCATATTTGCAAGTTATTGCAATGGAGGCAGGCATCCTCTAATGGCGGAA
CATAACTCACCCTTGTTTGC

Downstream 100 bases:

>100_bases
ATGGATTATAGATTGAATGATAGATGATGAATGATAAATTATGTGGTGCAGTAGGGGCGTATTCCATATACGCCCTAACG
GAGTTGGTTTTGTAGATGTT

Product: drug resistance protein

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKRSPLFILLLTVLLDLIGFGIVLPLLPTYTKSLGANPFMIGLIAAIFSIMQFIFSPLWGKLSDKIGRRPVMLSSILLTS
LSYLMFAQATTLPLLILARALAGVGSANVSAAQAYITDVTDAKGRSGAMGMMGAAFGIGFIVGPLLGGVLMHNYGIAVVG
YVASLLIAIDFILAIFFLPESNKAAIPFTHLLKGNENKGTRHGKKQSLGTTLATKVQEYNEHFRTTFSSRPLALLMVANF
IYTLAIVNMQTASILLWKEYFKASDEQIGYLFAYVGIWSVVVQGGLIGKLTKKVGEHNIFLWGHLFTFFGVFFMPFLPSY
SLFSMGLTVLFFFAIGTSLVAPINLSMISLYSYNQQQGQIMGLSQSVNAFARILGPFSGSILYGMSFHAPYIVAGILTLV
GAVIALRLFRYRIEAHD

Sequences:

>Translated_417_residues
MKRSPLFILLLTVLLDLIGFGIVLPLLPTYTKSLGANPFMIGLIAAIFSIMQFIFSPLWGKLSDKIGRRPVMLSSILLTS
LSYLMFAQATTLPLLILARALAGVGSANVSAAQAYITDVTDAKGRSGAMGMMGAAFGIGFIVGPLLGGVLMHNYGIAVVG
YVASLLIAIDFILAIFFLPESNKAAIPFTHLLKGNENKGTRHGKKQSLGTTLATKVQEYNEHFRTTFSSRPLALLMVANF
IYTLAIVNMQTASILLWKEYFKASDEQIGYLFAYVGIWSVVVQGGLIGKLTKKVGEHNIFLWGHLFTFFGVFFMPFLPSY
SLFSMGLTVLFFFAIGTSLVAPINLSMISLYSYNQQQGQIMGLSQSVNAFARILGPFSGSILYGMSFHAPYIVAGILTLV
GAVIALRLFRYRIEAHD
>Mature_417_residues
MKRSPLFILLLTVLLDLIGFGIVLPLLPTYTKSLGANPFMIGLIAAIFSIMQFIFSPLWGKLSDKIGRRPVMLSSILLTS
LSYLMFAQATTLPLLILARALAGVGSANVSAAQAYITDVTDAKGRSGAMGMMGAAFGIGFIVGPLLGGVLMHNYGIAVVG
YVASLLIAIDFILAIFFLPESNKAAIPFTHLLKGNENKGTRHGKKQSLGTTLATKVQEYNEHFRTTFSSRPLALLMVANF
IYTLAIVNMQTASILLWKEYFKASDEQIGYLFAYVGIWSVVVQGGLIGKLTKKVGEHNIFLWGHLFTFFGVFFMPFLPSY
SLFSMGLTVLFFFAIGTSLVAPINLSMISLYSYNQQQGQIMGLSQSVNAFARILGPFSGSILYGMSFHAPYIVAGILTLV
GAVIALRLFRYRIEAHD

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=415, Percent_Identity=27.4698795180723, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI225703104, Length=344, Percent_Identity=26.1627906976744, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225703102, Length=344, Percent_Identity=26.1627906976744, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI166064062, Length=388, Percent_Identity=27.5773195876289, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI166064060, Length=388, Percent_Identity=27.5773195876289, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI94721311, Length=425, Percent_Identity=22.8235294117647, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI39753965, Length=389, Percent_Identity=21.0796915167095, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87081738, Length=190, Percent_Identity=31.5789473684211, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787291, Length=427, Percent_Identity=23.6533957845433, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551570, Length=429, Percent_Identity=23.0769230769231, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71996331, Length=405, Percent_Identity=23.2098765432099, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17738085, Length=383, Percent_Identity=28.1984334203655, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI221513297, Length=185, Percent_Identity=28.6486486486486, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24667557, Length=221, Percent_Identity=25.3393665158371, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357569, Length=370, Percent_Identity=21.8918918918919, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667561, Length=277, Percent_Identity=24.187725631769, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656463, Length=174, Percent_Identity=28.1609195402299, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656468, Length=174, Percent_Identity=28.1609195402299, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161080926, Length=174, Percent_Identity=28.1609195402299, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161080924, Length=174, Percent_Identity=28.1609195402299, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45442; Mature: 45442

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSPLFILLLTVLLDLIGFGIVLPLLPTYTKSLGANPFMIGLIAAIFSIMQFIFSPLWG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KLSDKIGRRPVMLSSILLTSLSYLMFAQATTLPLLILARALAGVGSANVSAAQAYITDVT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
DAKGRSGAMGMMGAAFGIGFIVGPLLGGVLMHNYGIAVVGYVASLLIAIDFILAIFFLPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SNKAAIPFTHLLKGNENKGTRHGKKQSLGTTLATKVQEYNEHFRTTFSSRPLALLMVANF
CCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IYTLAIVNMQTASILLWKEYFKASDEQIGYLFAYVGIWSVVVQGGLIGKLTKKVGEHNIF
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
LWGHLFTFFGVFFMPFLPSYSLFSMGLTVLFFFAIGTSLVAPINLSMISLYSYNQQQGQI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCE
MGLSQSVNAFARILGPFSGSILYGMSFHAPYIVAGILTLVGAVIALRLFRYRIEAHD
ECHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRSPLFILLLTVLLDLIGFGIVLPLLPTYTKSLGANPFMIGLIAAIFSIMQFIFSPLWG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KLSDKIGRRPVMLSSILLTSLSYLMFAQATTLPLLILARALAGVGSANVSAAQAYITDVT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
DAKGRSGAMGMMGAAFGIGFIVGPLLGGVLMHNYGIAVVGYVASLLIAIDFILAIFFLPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SNKAAIPFTHLLKGNENKGTRHGKKQSLGTTLATKVQEYNEHFRTTFSSRPLALLMVANF
CCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IYTLAIVNMQTASILLWKEYFKASDEQIGYLFAYVGIWSVVVQGGLIGKLTKKVGEHNIF
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
LWGHLFTFFGVFFMPFLPSYSLFSMGLTVLFFFAIGTSLVAPINLSMISLYSYNQQQGQI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCE
MGLSQSVNAFARILGPFSGSILYGMSFHAPYIVAGILTLVGAVIALRLFRYRIEAHD
ECHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]