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The map label for this gene is mrdB [H]

Identifier: 78188546

GI number: 78188546

Start: 672736

End: 674001

Strand: Reverse

Name: mrdB [H]

Synonym: Cag_0568

Alternate gene names: 78188546

Gene position: 674001-672736 (Counterclockwise)

Preceding gene: 78188548

Following gene: 78188544

Centisome position: 26.2

GC content: 40.13

Gene sequence:

>1266_bases
ATGCTCAGTAATAAACGCCAAAAGCTTGATCTCTGGTATGTTGCCTCCATTGCGGGGCTTATTCTTATGGGATTTATGGC
AGTCTTTAGTGCAACATATGGTAGTGGCGATAGTACACTCTTTTATCGCCAAGTTGCATGGGGAGGCATTGGGCTTATCA
TTATGGCATTTATGTATTTTAATGATGCTCGTGTTATACGCGACAATGCCTACATTTTTTATGCCATTGGCTTAGTGCTG
TTAGTGGCTGTGTTGATTTTTGGAAAAAAAATTGCAGGGCAAACAAGTTGGATGCGTATTGGTTTTTTTAGTTTTCAGCC
ATCTGAAATTGTAAAATTAACCACCATTTTTGGCTTAGCTCGCTTTCTTTCCGACGACAACACCGATATCACCAATATTC
CTCATCTTGTTATGGCATTTGCCATAGCCTTTGTGCCTGTGCTTCTTATTATGTTGCAACCCGATATGGGCACTATGCTT
ACCATTATGCCATTTATTGCCGTAATGCTCATTATGGCTGGTTTTGATCTCTACATTTTAATACTGTTAGCATTCCCGAT
AGTGTTAATGATATCGGGATTTTTTAATGTGTGGGTTGTTGTTGCCTTAGCCGTTGTATTACTTATTGCGTTAATTATGC
AACGCCAAAAAGTGCAGCTTCATCAATTTTTAGTAATTGGTGGTGGGTTAGCCGCTGGACTTTTTATGCACCGCTTTGCC
AGCGAAATTTTAAAACCTCATCAATTAAAACGCATTCAAACCTTTATTGACCCCATGTCGGATCCTCAAGGGGCTGGCTA
TAATGCGTTGCAAGCAAAAATTGCCATTACATCGGGGGGATTGTTTGGGAAAGGTTTTCTTGAAGGTACGCAAACGCAAT
TACGGTTTATTCCTGCCCAATGGACAGACTTTATTTTTTGTGTTATTGCTGAAGAGCTTGGCTTTATAGGCGCTGCTTTG
CTGTTAAGCTTCTACTTAATATTCATTTTAAAGCTTATTGCCACCATTTTTGCGATTCATAATAAATTTATACAGCTCAC
CTTAAGTGGTTTTGTTTCGCTAATTTTTATTCATGTGCTCATTAATGTAGGCATGACAATAGGCTTAATTCCCGTAATTG
GCGTGCCGCTGCCCTTTGTGTCGTATGGTGGAACCTCGTTGGTGGGTAATATGATTATGGCTGGCTTGGCGCTTAACTAT
GCTCGCAATAAACGAAGTTTAGGCTACTATGCTCGAGAGGAGGTAATTAGAAAAAGCGCACCGTAA

Upstream 100 bases:

>100_bases
AAGTATTGGTTGGCTCTTGCCACAAAAAAAATAAAGCACGTTGTTTTAAGGACGTTGTGCTTTAATAACATCATTTTATA
GAAAAAAACAGAAGAAAGCT

Downstream 100 bases:

>100_bases
TGCGCTTTTTCCAATTTCGAGGAGGAGAGAAAAATGTACAGCAAGAATAACTTTAGTTAACCGTATAAACAAAACGTTTG
CCTTCGGGTCCCGTTGGAAT

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MLSNKRQKLDLWYVASIAGLILMGFMAVFSATYGSGDSTLFYRQVAWGGIGLIIMAFMYFNDARVIRDNAYIFYAIGLVL
LVAVLIFGKKIAGQTSWMRIGFFSFQPSEIVKLTTIFGLARFLSDDNTDITNIPHLVMAFAIAFVPVLLIMLQPDMGTML
TIMPFIAVMLIMAGFDLYILILLAFPIVLMISGFFNVWVVVALAVVLLIALIMQRQKVQLHQFLVIGGGLAAGLFMHRFA
SEILKPHQLKRIQTFIDPMSDPQGAGYNALQAKIAITSGGLFGKGFLEGTQTQLRFIPAQWTDFIFCVIAEELGFIGAAL
LLSFYLIFILKLIATIFAIHNKFIQLTLSGFVSLIFIHVLINVGMTIGLIPVIGVPLPFVSYGGTSLVGNMIMAGLALNY
ARNKRSLGYYAREEVIRKSAP

Sequences:

>Translated_421_residues
MLSNKRQKLDLWYVASIAGLILMGFMAVFSATYGSGDSTLFYRQVAWGGIGLIIMAFMYFNDARVIRDNAYIFYAIGLVL
LVAVLIFGKKIAGQTSWMRIGFFSFQPSEIVKLTTIFGLARFLSDDNTDITNIPHLVMAFAIAFVPVLLIMLQPDMGTML
TIMPFIAVMLIMAGFDLYILILLAFPIVLMISGFFNVWVVVALAVVLLIALIMQRQKVQLHQFLVIGGGLAAGLFMHRFA
SEILKPHQLKRIQTFIDPMSDPQGAGYNALQAKIAITSGGLFGKGFLEGTQTQLRFIPAQWTDFIFCVIAEELGFIGAAL
LLSFYLIFILKLIATIFAIHNKFIQLTLSGFVSLIFIHVLINVGMTIGLIPVIGVPLPFVSYGGTSLVGNMIMAGLALNY
ARNKRSLGYYAREEVIRKSAP
>Mature_421_residues
MLSNKRQKLDLWYVASIAGLILMGFMAVFSATYGSGDSTLFYRQVAWGGIGLIIMAFMYFNDARVIRDNAYIFYAIGLVL
LVAVLIFGKKIAGQTSWMRIGFFSFQPSEIVKLTTIFGLARFLSDDNTDITNIPHLVMAFAIAFVPVLLIMLQPDMGTML
TIMPFIAVMLIMAGFDLYILILLAFPIVLMISGFFNVWVVVALAVVLLIALIMQRQKVQLHQFLVIGGGLAAGLFMHRFA
SEILKPHQLKRIQTFIDPMSDPQGAGYNALQAKIAITSGGLFGKGFLEGTQTQLRFIPAQWTDFIFCVIAEELGFIGAAL
LLSFYLIFILKLIATIFAIHNKFIQLTLSGFVSLIFIHVLINVGMTIGLIPVIGVPLPFVSYGGTSLVGNMIMAGLALNY
ARNKRSLGYYAREEVIRKSAP

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=371, Percent_Identity=35.8490566037736, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786277, Length=334, Percent_Identity=28.7425149700599, Blast_Score=121, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 46506; Mature: 46506

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSNKRQKLDLWYVASIAGLILMGFMAVFSATYGSGDSTLFYRQVAWGGIGLIIMAFMYF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCHHHHHHHHHHHH
NDARVIRDNAYIFYAIGLVLLVAVLIFGKKIAGQTSWMRIGFFSFQPSEIVKLTTIFGLA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHH
RFLSDDNTDITNIPHLVMAFAIAFVPVLLIMLQPDMGTMLTIMPFIAVMLIMAGFDLYIL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ILLAFPIVLMISGFFNVWVVVALAVVLLIALIMQRQKVQLHQFLVIGGGLAAGLFMHRFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SEILKPHQLKRIQTFIDPMSDPQGAGYNALQAKIAITSGGLFGKGFLEGTQTQLRFIPAQ
HHHHCHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEECCCCCCCHHHCCCCHHHEEECHH
WTDFIFCVIAEELGFIGAALLLSFYLIFILKLIATIFAIHNKFIQLTLSGFVSLIFIHVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INVGMTIGLIPVIGVPLPFVSYGGTSLVGNMIMAGLALNYARNKRSLGYYAREEVIRKSA
HHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
P
C
>Mature Secondary Structure
MLSNKRQKLDLWYVASIAGLILMGFMAVFSATYGSGDSTLFYRQVAWGGIGLIIMAFMYF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHCHHHHHHHHHHHH
NDARVIRDNAYIFYAIGLVLLVAVLIFGKKIAGQTSWMRIGFFSFQPSEIVKLTTIFGLA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHH
RFLSDDNTDITNIPHLVMAFAIAFVPVLLIMLQPDMGTMLTIMPFIAVMLIMAGFDLYIL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ILLAFPIVLMISGFFNVWVVVALAVVLLIALIMQRQKVQLHQFLVIGGGLAAGLFMHRFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SEILKPHQLKRIQTFIDPMSDPQGAGYNALQAKIAITSGGLFGKGFLEGTQTQLRFIPAQ
HHHHCHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEECCCCCCCHHHCCCCHHHEEECHH
WTDFIFCVIAEELGFIGAALLLSFYLIFILKLIATIFAIHNKFIQLTLSGFVSLIFIHVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INVGMTIGLIPVIGVPLPFVSYGGTSLVGNMIMAGLALNYARNKRSLGYYAREEVIRKSA
HHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]