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The map label for this gene is apt [H]

Identifier: 78188543

GI number: 78188543

Start: 669928

End: 670521

Strand: Reverse

Name: apt [H]

Synonym: Cag_0565

Alternate gene names: 78188543

Gene position: 670521-669928 (Counterclockwise)

Preceding gene: 78188544

Following gene: 78188541

Centisome position: 26.07

GC content: 46.13

Gene sequence:

>594_bases
ATGAGCCGCATAGTGCAGCTCGCCCCATGTTTCTTTACAAACCATAAAATCCACACCTCCATGCCAATTAAATCTCGTAT
TCGCTCCATTCCCGATTACCCTAAAAAGGGCATTATGTTTCGCGACATCACAACGCTTATTAAAGACCCCGTTGGATTTC
GTTTAGTGATTGACCACCTTACCCAGCACTACCTTGAAGCTGGCATGGATTTTGATGTTATTGTTGGTATTGAAGCGCGT
GGCTTTATTATTGGTGGGGCGCTCTCTTACACGCTTGGCAAAGGCTTTGTGCCTGTACGTAAGCCGGGTAAATTACCTGC
TGATGTGGTTTCGCAGGAGTATGAGCTTGAGTATGGTAGCGATAAAATTGAAATTCACACCGATGCCTTAGTTGAAGGGC
AGCGTGTGTTGCTGGTTGATGATTTACTTGCTACGGGTGGAACGGCACTTGCAGCCGCCGCACTTGTGGAGAAAGTTGGT
GGCATTGTAGCTGAAATGGCGTTTATTGTGAATTTGCCCGATGTGGGTGGCGAAAGAAAGTTGCTTGAAAAAGGCTACAA
CGTTTACTCGCTTACTGATTTTGAGGGCGATTAA

Upstream 100 bases:

>100_bases
AGCTGATACTTTTGCTGGGCAGGAAATATTGGTGCGGCTTGAGCAGCTTGATGACGATTTGAATTTCATAGGGAGTGTAC
TATCTTGATGCCACTTTTTT

Downstream 100 bases:

>100_bases
GCAACGCCATTGCAACTCCCCTTCCCTTGGTGATTACCAATAAAAAAAACGGCAGCTTGTTAGACTGCCGTTTTTTTATT
GGTTATGCTTACACATCCCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MSRIVQLAPCFFTNHKIHTSMPIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDHLTQHYLEAGMDFDVIVGIEAR
GFIIGGALSYTLGKGFVPVRKPGKLPADVVSQEYELEYGSDKIEIHTDALVEGQRVLLVDDLLATGGTALAAAALVEKVG
GIVAEMAFIVNLPDVGGERKLLEKGYNVYSLTDFEGD

Sequences:

>Translated_197_residues
MSRIVQLAPCFFTNHKIHTSMPIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDHLTQHYLEAGMDFDVIVGIEAR
GFIIGGALSYTLGKGFVPVRKPGKLPADVVSQEYELEYGSDKIEIHTDALVEGQRVLLVDDLLATGGTALAAAALVEKVG
GIVAEMAFIVNLPDVGGERKLLEKGYNVYSLTDFEGD
>Mature_196_residues
SRIVQLAPCFFTNHKIHTSMPIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDHLTQHYLEAGMDFDVIVGIEARG
FIIGGALSYTLGKGFVPVRKPGKLPADVVSQEYELEYGSDKIEIHTDALVEGQRVLLVDDLLATGGTALAAAALVEKVGG
IVAEMAFIVNLPDVGGERKLLEKGYNVYSLTDFEGD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=175, Percent_Identity=44.5714285714286, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI71773201, Length=126, Percent_Identity=50, Blast_Score=121, Evalue=4e-28,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=53.448275862069, Blast_Score=188, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=40.4624277456647, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=161, Percent_Identity=42.2360248447205, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=163, Percent_Identity=37.4233128834356, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=44.0251572327044, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 21578; Mature: 21447

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIVQLAPCFFTNHKIHTSMPIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDHL
CCCHHEECCEEEECCEEEECCCHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHHH
TQHYLEAGMDFDVIVGIEARGFIIGGALSYTLGKGFVPVRKPGKLPADVVSQEYELEYGS
HHHHHHCCCCEEEEEEEECCCEEEECHHHHHHCCCCCCCCCCCCCCHHHHCCCEEEECCC
DKIEIHTDALVEGQRVLLVDDLLATGGTALAAAALVEKVGGIVAEMAFIVNLPDVGGERK
CEEEEEECHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHH
LLEKGYNVYSLTDFEGD
HHHCCCCEEEEECCCCC
>Mature Secondary Structure 
SRIVQLAPCFFTNHKIHTSMPIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDHL
CCHHEECCEEEECCEEEECCCHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHHH
TQHYLEAGMDFDVIVGIEARGFIIGGALSYTLGKGFVPVRKPGKLPADVVSQEYELEYGS
HHHHHHCCCCEEEEEEEECCCEEEECHHHHHHCCCCCCCCCCCCCCHHHHCCCEEEECCC
DKIEIHTDALVEGQRVLLVDDLLATGGTALAAAALVEKVGGIVAEMAFIVNLPDVGGERK
CEEEEEECHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHH
LLEKGYNVYSLTDFEGD
HHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA