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The map label for this gene is lon [H]

Identifier: 78067865

GI number: 78067865

Start: 3565028

End: 3566008

Strand: Reverse

Name: lon [H]

Synonym: Bcep18194_A6396

Alternate gene names: 78067865

Gene position: 3566008-3565028 (Counterclockwise)

Preceding gene: 78067876

Following gene: 78067864

Centisome position: 96.53

GC content: 67.38

Gene sequence:

>981_bases
ATGACGACGGCGATGGTGAAACAGGAACTGGCGGTGGCGTCCTTCAGCACGGTGTACGACCTCGAGCAGGTCGAGACGGC
GCTGAGTGACCTGAACGAGAGCGCGAGCGACGCACTGCGCGCCACCTACGAGAGGATGCTCAAGACGGGCAATCTGCGCT
TCTGCGTGAAGCCGAACCGGATGCCGTCGTTCGACGCGCTCGGCGAGGCATTACCCAATTTCGCCGAGCCGCTCGACGAC
GTGCGCAAGCAGGTCGCACTGTGCCTCGAAACGGACGACCGGCTCGAACTGATGCCGATCCTGCTGCTCGGGCCCCCGGG
CATCGGCAAGACGCACTTCGCGAAGGCGCTCGCGCAACTGCTCGGCACCGCGTACCACTACGTGCCGATGAGTTCGCTGA
CGGCCGGCTGGATCCTGTCGGGTGCGTCGTCGCAATGGAAGAACGCGAAGCCCGGCAAGGTGTTCGATGCGCTCGTGAAC
GGCAGCTACGCGAACCCAGTGATCGCGGTCGACGAGATCGACAAGGCCGGCAGCGATGCGCAATACGATCCGCTCGGCGC
GCTGTACGCGTTGCTCGAGCACGACACCGCGCGCGCATTCATCGACGAATTCGCGGAAGTGCCGATCGATGCGGGCAACG
TGATCTGGATCGCGACCGCGAACGACGCGCACGCGATTCCGGAGCCGCTGCTCAACCGGATGAACGTGTACGAAATCGAG
CCGCCCGATGCGGCCGGCGCGCGCCGGATTGCGCAGACGATCTACGACGAGATCCGCACGTCGCATGCGTGGGGGCGGCG
CTTCCCGGACATTCTCGGCGACGACGCGCTCGACGTGCTGGCCGCGACCGCGCCGCGCACGATGCGCCGCGCGCTGCTGC
ACGCATTCGGTGCCGCGCGGCTCGACGGCCGCGATGCGATCGGGCCGCGCGACATCCGGGCCGACGAGGGCGCCGCGAAG
CGCCGGCCGATCGGTTTCTGA

Upstream 100 bases:

>100_bases
AGACGCACGCGGCTGCTTGCTTGCGCGGGAATGCGGGATCGCTACACTGAAATCGTAAGGGTCTGATGGTCGTGTGACAG
CAAGCGGCAGCGAGGTTGGT

Downstream 100 bases:

>100_bases
ACGAGCGGCGCGCGCACGCCTCGGCGGCGTGCGCGCCGTGCAGTGCCGCGAATCGTGCCGTGCGTCGCGCGTCATGCACG
GCGTCGTCGCGATACGCTGC

Product: AAA ATPase, central region

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTTAMVKQELAVASFSTVYDLEQVETALSDLNESASDALRATYERMLKTGNLRFCVKPNRMPSFDALGEALPNFAEPLDD
VRKQVALCLETDDRLELMPILLLGPPGIGKTHFAKALAQLLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVN
GSYANPVIAVDEIDKAGSDAQYDPLGALYALLEHDTARAFIDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIE
PPDAAGARRIAQTIYDEIRTSHAWGRRFPDILGDDALDVLAATAPRTMRRALLHAFGAARLDGRDAIGPRDIRADEGAAK
RRPIGF

Sequences:

>Translated_326_residues
MTTAMVKQELAVASFSTVYDLEQVETALSDLNESASDALRATYERMLKTGNLRFCVKPNRMPSFDALGEALPNFAEPLDD
VRKQVALCLETDDRLELMPILLLGPPGIGKTHFAKALAQLLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVN
GSYANPVIAVDEIDKAGSDAQYDPLGALYALLEHDTARAFIDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIE
PPDAAGARRIAQTIYDEIRTSHAWGRRFPDILGDDALDVLAATAPRTMRRALLHAFGAARLDGRDAIGPRDIRADEGAAK
RRPIGF
>Mature_325_residues
TTAMVKQELAVASFSTVYDLEQVETALSDLNESASDALRATYERMLKTGNLRFCVKPNRMPSFDALGEALPNFAEPLDDV
RKQVALCLETDDRLELMPILLLGPPGIGKTHFAKALAQLLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNG
SYANPVIAVDEIDKAGSDAQYDPLGALYALLEHDTARAFIDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIEP
PDAAGARRIAQTIYDEIRTSHAWGRRFPDILGDDALDVLAATAPRTMRRALLHAFGAARLDGRDAIGPRDIRADEGAAKR
RPIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=140, Percent_Identity=35.7142857142857, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI31377667, Length=142, Percent_Identity=33.8028169014084, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1786643, Length=142, Percent_Identity=35.2112676056338, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17556486, Length=168, Percent_Identity=32.7380952380952, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17505831, Length=137, Percent_Identity=35.036496350365, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319449, Length=154, Percent_Identity=35.0649350649351, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24666867, Length=136, Percent_Identity=37.5, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221513036, Length=136, Percent_Identity=37.5, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 35474; Mature: 35342

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAMVKQELAVASFSTVYDLEQVETALSDLNESASDALRATYERMLKTGNLRFCVKPNR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCC
MPSFDALGEALPNFAEPLDDVRKQVALCLETDDRLELMPILLLGPPGIGKTHFAKALAQL
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGSDA
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTARAFIDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEC
PPDAAGARRIAQTIYDEIRTSHAWGRRFPDILGDDALDVLAATAPRTMRRALLHAFGAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHC
LDGRDAIGPRDIRADEGAAKRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTAMVKQELAVASFSTVYDLEQVETALSDLNESASDALRATYERMLKTGNLRFCVKPNR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCC
MPSFDALGEALPNFAEPLDDVRKQVALCLETDDRLELMPILLLGPPGIGKTHFAKALAQL
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGSDA
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTARAFIDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEC
PPDAAGARRIAQTIYDEIRTSHAWGRRFPDILGDDALDVLAATAPRTMRRALLHAFGAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHC
LDGRDAIGPRDIRADEGAAKRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA