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The map label for this gene is lhgO [H]

Identifier: 78067864

GI number: 78067864

Start: 3563741

End: 3564841

Strand: Reverse

Name: lhgO [H]

Synonym: Bcep18194_A6395

Alternate gene names: 78067864

Gene position: 3564841-3563741 (Counterclockwise)

Preceding gene: 78067865

Following gene: 78067863

Centisome position: 96.5

GC content: 70.94

Gene sequence:

>1101_bases
ATGGATTGTGTCGTGATCGGCGCGGGTGTCGTCGGTCTTGCGATTGCGCGCGAACTGGCCGCGCGCGGGCGTGAAACGCT
CGTGCTCGAGGCTGCCGATGCGATCGGCACCGGTACGAGTTCGCGCAACAGCGAAGTGATCCATGCGGGGCTCTACTATC
CGCGCGGGTCGCTGAAGGCGATGTCGTGCGTGCACGGGCGCGACCTGCTGTACGAATTCTGCGAGACGCGTCACGTGCCG
CACCGGCGTGCCGGCAAGTTGCTCGTCGCCACGAGCGCCGCGCAGGTGAAGCAGTTGAAGGCGATTGCCGTACGCGCGAC
CGAAAACGGCGTGCTCGACCTGATGCCGCTCACGCGCGCCGAAGCGCAGACGCTCGAGCCTGCGCTCGAGTGCGTCGAGG
CGCTGTTCTCGCCGTCCACCGGCATCGTCGACAGCCACCAGCTGATGCTCGCGCTGCTCGGCGACGCGGAGCGCGACGGC
GCGGTGTGTGCGCTGAAATCCCCGGTCGAATCGATCGACGTGCTGCGCGGCGGCCGCTTCGTCGTGCGCACGGGCGGCGA
CGCGCCGACCGAGATCGAGGCCGCCTGCGTGATCAACAGCGCGGGCCTCGGCGCACAGGCGCTGGCGCGCCGCACGCGCG
GCCTCGACCCGCGCTGGGTGCCGCCGCTGTATCTCGCGCGCGGCAACTATTTCAGCCTGTCGGGGCGTGCACCGTTCTCG
CACCTGATCTACCCGATGCCCGACCGCGCGGGGCTCGGCGTGCACCTGACGCTCGATCTCGGCGGGCAGGCGCGCTTCGG
CCCGGACGTCGAATGGGTCGATGCGTTGCGCTACGAAGTCGATCCCGCGCGCGCGACCGCGTTCTACGCGTCGATTCGCG
CATTCTGGCCGGGCCTGCCCGACGACGCGCTGCAGCCGGCGTACGCGGGCATCCGGCCGAAGGTCGCGGGGCCCGGCGAG
CCGCCGGCCGATTTCATCGTGCAGGGCGCCGCGCAGCATGGCGTGCGCGGGCTCGTGAACCTGTTCGGCATCGAGTCGCC
GGGGCTCACCGCGTCGCTCGCGCTCGCGCAGCGCGTGGGCGACATGGCGGCTTACCACTGA

Upstream 100 bases:

>100_bases
TCGCGATACGCTGCACGACCTTCGGCAAGCGGGTGAACCGGGACGTACAATTCTCTTCTCTCCCCTCGACGCGCTAGCGG
CGCGAAACGTCATGGAGCAG

Downstream 100 bases:

>100_bases
CGCGGCGCGTGTGTGGCGGGGGTGTGGTGGAACCGTGGCGGGCGCGTATCGGCCGTGTGGCGGCTGTGTGAAATTCCTTA
TCTCTGGAATTTCGGCGCGC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKAMSCVHGRDLLYEFCETRHVP
HRRAGKLLVATSAAQVKQLKAIAVRATENGVLDLMPLTRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAERDG
AVCALKSPVESIDVLRGGRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRAPFS
HLIYPMPDRAGLGVHLTLDLGGQARFGPDVEWVDALRYEVDPARATAFYASIRAFWPGLPDDALQPAYAGIRPKVAGPGE
PPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGDMAAYH

Sequences:

>Translated_366_residues
MDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKAMSCVHGRDLLYEFCETRHVP
HRRAGKLLVATSAAQVKQLKAIAVRATENGVLDLMPLTRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAERDG
AVCALKSPVESIDVLRGGRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRAPFS
HLIYPMPDRAGLGVHLTLDLGGQARFGPDVEWVDALRYEVDPARATAFYASIRAFWPGLPDDALQPAYAGIRPKVAGPGE
PPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGDMAAYH
>Mature_366_residues
MDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKAMSCVHGRDLLYEFCETRHVP
HRRAGKLLVATSAAQVKQLKAIAVRATENGVLDLMPLTRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAERDG
AVCALKSPVESIDVLRGGRFVVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRAPFS
HLIYPMPDRAGLGVHLTLDLGGQARFGPDVEWVDALRYEVDPARATAFYASIRAFWPGLPDDALQPAYAGIRPKVAGPGE
PPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGDMAAYH

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=258, Percent_Identity=32.5581395348837, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI87082148, Length=247, Percent_Identity=33.1983805668016, Blast_Score=111, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17565764, Length=276, Percent_Identity=36.231884057971, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24585081, Length=397, Percent_Identity=30.4785894206549, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38746; Mature: 38746

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKA
CCEEEEECHHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCEEEEEEECCCCCCHH
MSCVHGRDLLYEFCETRHVPHRRAGKLLVATSAAQVKQLKAIAVRATENGVLDLMPLTRA
HHHHHHHHHHHHHHHHCCCCCHHHCCEEEEECHHHHHHHHHHEEEECCCCCEEEECCCHH
EAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAERDGAVCALKSPVESIDVLRGGRF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCEE
VVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRAPFS
EEECCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCHH
HLIYPMPDRAGLGVHLTLDLGGQARFGPDVEWVDALRYEVDPARATAFYASIRAFWPGLP
HCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
DDALQPAYAGIRPKVAGPGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVG
CHHCCCHHCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DMAAYH
HHHCCC
>Mature Secondary Structure
MDCVVIGAGVVGLAIARELAARGRETLVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKA
CCEEEEECHHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCEEEEEEECCCCCCHH
MSCVHGRDLLYEFCETRHVPHRRAGKLLVATSAAQVKQLKAIAVRATENGVLDLMPLTRA
HHHHHHHHHHHHHHHHCCCCCHHHCCEEEEECHHHHHHHHHHEEEECCCCCEEEECCCHH
EAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAERDGAVCALKSPVESIDVLRGGRF
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCEE
VVRTGGDAPTEIEAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRAPFS
EEECCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCHH
HLIYPMPDRAGLGVHLTLDLGGQARFGPDVEWVDALRYEVDPARATAFYASIRAFWPGLP
HCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
DDALQPAYAGIRPKVAGPGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVG
CHHCCCHHCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DMAAYH
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]