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The map label for this gene is gor [H]

Identifier: 78067821

GI number: 78067821

Start: 3517629

End: 3518987

Strand: Reverse

Name: gor [H]

Synonym: Bcep18194_A6352

Alternate gene names: 78067821

Gene position: 3518987-3517629 (Counterclockwise)

Preceding gene: 78067822

Following gene: 78067809

Centisome position: 95.26

GC content: 69.24

Gene sequence:

>1359_bases
ATGGATTTCGACTACGACCTGTTCGTCATCGGTGCCGGCTCGGGCGGCGTGCGGCTTGCGCGCATGTCCGCGTCATACGG
CGCGCGTGTCGGCATAGCGGAAGAAGAGCAGATCGGCGGCACCTGCGTGCTGCGCGGCTGCATCCCGAAGAAGCTGCTCG
TCTACGCATCGCACTACCCGCATGAAGTCGAGGACGCGAAGGGCTTCGGCTGGCGCTTCGGCGCCGGCACGCTCGACTGG
CCCGCGCTGATCGCCGCGAAGGATCGCGAGATCAACCGGCTGAGCGACATCTACATCAACCTGCTGCGGCAATCGGGCGT
CGAGATGCACGCGGGGCGCGCGACGCTCGTCGATGCGCACACGGTCGCGATCGGCGACCGCACGATCCGCGCGCGCCACA
TCGCGATCGCGACCGGCTCGCGTCCGTCGATGCCCGCGCGGCCCGGCATCGAGCACGCGATCACGTCGCGCGAGGCGCTG
TCGCTTGCCGCGCTGCCCAAACGTATCGCGGTGGTCGGCGGCGGCTATATCGCGGTCGAGTTCGCGGGCATCTTCAACGG
CTTCGGCAGCCACGTCGACCTGTTCTATCGCGGCGAGAAAATCCTGCGCGGCTTCGACGACGACGTGCGCCAGTTCCTGA
CCGACGAGATGACGAAGCAGGGCGTCACGATCCACGCGCGCTCGGTGGTCGAGTCGATCGAGCGCGCGGACGACGGCACG
CTGAGCGTGCGCGTCGGCGATGCGCGGCACGGGCCGTACGACCAGGTGCTCTATGCGACGGGGCGCGTACCGAACGTCGA
CGGGCTCGGGCTCGAGCAGGCGGGTGTGGCGCTCGATGCGCGCGGCGCGATTGCCGTCGATGCGTATTCGGCGACGTCGG
TGCCGTCGATCCATGCGATCGGCGACGTCACGTCGCGGCCGCAGCTCACGCCGGTCGCGACGCGCGACGGCGCGTTGCTC
GCCCGCACGCTGTTCGGCGGGTCGCGCGTCGCGGCCGATCACGAATGGGTGCCGTCGGCGGTGTTCAGCCAACCCGAAGT
CGCGACGGTCGGCCTCACCGAGTCGACCGCGCGCGACCTGTACGACGGCGACGTCGACATCTACCGCACGTCGTTCAAGG
CGCTGCGTCATACGCTGTCGGGCCGCGACGAGCGCACGCTGATGAAGCTCGTCGTTGCGCGCGACAGCCAGCGCGTGGTC
GGTGCACACATGGTCGGCCGCGATGCGGGCGAGATCATCCAGGGCATCGCGATCGCGATTCGCGCGGGCGCGACGAAGGC
GCAGTTCGACGACACGATCGGCATTCACCCGACCGCGGCCGAGGAGTTCGTGACGATGCGGCAGAAGGTGGCCGACTAG

Upstream 100 bases:

>100_bases
CGCCGTTTTTTATTGGGCGCGCGCCGGGCGGCACCGTGCGCCGCAAGAATTCCGGAATCTTGCTATCGTGCCTTCATCCG
AACTGCGATGAGGGAATGCG

Downstream 100 bases:

>100_bases
CGGGAGCGCGTCGCGCGCGGCGGCAAGGGAACGGCTGCGTGTCGGCGCGGCCGTTTCTCGTTGATGTGGCCGCCGCTCAA
TGCACGCCGAACGCGTCGAG

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYPHEVEDAKGFGWRFGAGTLDW
PALIAAKDREINRLSDIYINLLRQSGVEMHAGRATLVDAHTVAIGDRTIRARHIAIATGSRPSMPARPGIEHAITSREAL
SLAALPKRIAVVGGGYIAVEFAGIFNGFGSHVDLFYRGEKILRGFDDDVRQFLTDEMTKQGVTIHARSVVESIERADDGT
LSVRVGDARHGPYDQVLYATGRVPNVDGLGLEQAGVALDARGAIAVDAYSATSVPSIHAIGDVTSRPQLTPVATRDGALL
ARTLFGGSRVAADHEWVPSAVFSQPEVATVGLTESTARDLYDGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVV
GAHMVGRDAGEIIQGIAIAIRAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD

Sequences:

>Translated_452_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYPHEVEDAKGFGWRFGAGTLDW
PALIAAKDREINRLSDIYINLLRQSGVEMHAGRATLVDAHTVAIGDRTIRARHIAIATGSRPSMPARPGIEHAITSREAL
SLAALPKRIAVVGGGYIAVEFAGIFNGFGSHVDLFYRGEKILRGFDDDVRQFLTDEMTKQGVTIHARSVVESIERADDGT
LSVRVGDARHGPYDQVLYATGRVPNVDGLGLEQAGVALDARGAIAVDAYSATSVPSIHAIGDVTSRPQLTPVATRDGALL
ARTLFGGSRVAADHEWVPSAVFSQPEVATVGLTESTARDLYDGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVV
GAHMVGRDAGEIIQGIAIAIRAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD
>Mature_452_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYPHEVEDAKGFGWRFGAGTLDW
PALIAAKDREINRLSDIYINLLRQSGVEMHAGRATLVDAHTVAIGDRTIRARHIAIATGSRPSMPARPGIEHAITSREAL
SLAALPKRIAVVGGGYIAVEFAGIFNGFGSHVDLFYRGEKILRGFDDDVRQFLTDEMTKQGVTIHARSVVESIERADDGT
LSVRVGDARHGPYDQVLYATGRVPNVDGLGLEQAGVALDARGAIAVDAYSATSVPSIHAIGDVTSRPQLTPVATRDGALL
ARTLFGGSRVAADHEWVPSAVFSQPEVATVGLTESTARDLYDGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVV
GAHMVGRDAGEIIQGIAIAIRAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=38.7799564270153, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=37.7118644067797, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI291045266, Length=475, Percent_Identity=34.7368421052632, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=35.0951374207188, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=35.0951374207188, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=35.0951374207188, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=35.0951374207188, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=35.0951374207188, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI291045268, Length=474, Percent_Identity=32.4894514767932, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=30.4347826086957, Blast_Score=188, Evalue=9e-48,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=39.9532710280374, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=30.242825607064, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87082354, Length=453, Percent_Identity=30.4635761589404, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=30.9734513274336, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=38.1696428571429, Blast_Score=277, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=38.1696428571429, Blast_Score=277, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI17557007, Length=467, Percent_Identity=34.2612419700214, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=32.4324324324324, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=32.1739130434783, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=36.8763557483731, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=28.2655246252677, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=27.2921108742004, Blast_Score=152, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=37.5266524520256, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=37.5266524520256, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=37.5266524520256, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=35.8811040339703, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=31.0722100656455, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48487; Mature: 48487

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYP
CCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHCCCEEEEECCCCCCCEEEECCCC
HEVEDAKGFGWRFGAGTLDWPALIAAKDREINRLSDIYINLLRQSGVEMHAGRATLVDAH
CCCCCCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCEEEEEEE
TVAIGDRTIRARHIAIATGSRPSMPARPGIEHAITSREALSLAALPKRIAVVGGGYIAVE
EEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCEEEEE
FAGIFNGFGSHVDLFYRGEKILRGFDDDVRQFLTDEMTKQGVTIHARSVVESIERADDGT
EEHHHCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCE
LSVRVGDARHGPYDQVLYATGRVPNVDGLGLEQAGVALDARGAIAVDAYSATSVPSIHAI
EEEEECCCCCCCCHHEEEECCCCCCCCCCCCHHCCEEEECCCEEEEECCCCCCCCCEEEC
GDVTSRPQLTPVATRDGALLARTLFGGSRVAADHEWVPSAVFSQPEVATVGLTESTARDL
CCCCCCCCCCEEECCCCCEEEHHHCCCCEECCCCCCCCHHHCCCCCEEEEECCHHHHHHH
YDGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVGAHMVGRDAGEIIQGIAIAI
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHEEE
RAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYP
CCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHCCCEEEEECCCCCCCEEEECCCC
HEVEDAKGFGWRFGAGTLDWPALIAAKDREINRLSDIYINLLRQSGVEMHAGRATLVDAH
CCCCCCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCEEEEEEE
TVAIGDRTIRARHIAIATGSRPSMPARPGIEHAITSREALSLAALPKRIAVVGGGYIAVE
EEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCEEEEE
FAGIFNGFGSHVDLFYRGEKILRGFDDDVRQFLTDEMTKQGVTIHARSVVESIERADDGT
EEHHHCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCE
LSVRVGDARHGPYDQVLYATGRVPNVDGLGLEQAGVALDARGAIAVDAYSATSVPSIHAI
EEEEECCCCCCCCHHEEEECCCCCCCCCCCCHHCCEEEECCCEEEEECCCCCCCCCEEEC
GDVTSRPQLTPVATRDGALLARTLFGGSRVAADHEWVPSAVFSQPEVATVGLTESTARDL
CCCCCCCCCCEEECCCCCEEEHHHCCCCEECCCCCCCCHHHCCCCCEEEEECCHHHHHHH
YDGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVGAHMVGRDAGEIIQGIAIAI
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHEEE
RAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]