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The map label for this gene is ilvA [H]

Identifier: 78067533

GI number: 78067533

Start: 3206428

End: 3207951

Strand: Direct

Name: ilvA [H]

Synonym: Bcep18194_A6064

Alternate gene names: 78067533

Gene position: 3206428-3207951 (Clockwise)

Preceding gene: 78067532

Following gene: 78067534

Centisome position: 86.8

GC content: 66.73

Gene sequence:

>1524_bases
ATGGCATCCCACGATTACCTGAAGAAAATCCTCACCGCGCGCGTCTACGACGTCGCGATCGAGACGGAACTCGAATCCGC
CCGCATCCTGTCGGCCCGGCTGCGCAATGCGGTCTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGC
GCGGCGCATACAACAAGATGGCGCACATTCCGGCGGACGCGCTCGCGCGCGGCGTGATTACGGCATCGGCCGGCAACCAC
GCGCAGGGTGTCGCGTTCTCGGCGGCCCGGATGGGCGTGAAGGCCGTGATCGTCGTGCCCGTCACGACGCCGCAGGTGAA
GGTCGATGCGGTGCGTGCGCACGGCGGCCCGAGCGTCGAGGTGATCCAGGCCGGCGAGTCGTACAGCGATGCGTATGCAC
ACGCGGTCAAGGTGCAGGAAGAGCGCGGCCTCACGTTCGTCCACCCGTTCGACGATCCGTACGTGATCGCCGGCCAGGGC
ACGATCGCGATGGAAATCCTGCGCCAGCACCAGGGCCCGATCCATGCGATCTTCGTGCCGATCGGCGGCGGCGGGCTCGC
GTCCGGCGTCGCGGCCTACGTGAAGGCGGTGCGCCCGGAGATCAAGGTGATCGGCGTGCAAGCCGAAGATTCGTGCGCGA
TGGCGCAGTCGCTGGAAGCCGGCAGGCGTGTCGAGCTGAGCGAGGTCGGCCTGTTCGCGGACGGTACCGCCGTGAAGCTG
GTCGGCGAGGAAACCTTCCGCCTCTGCAGCGAATACCTCGACGGCGTCGTGACGGTGAACACCGACGCGCTGTGCGCGGC
GATCAAGGACGTCTTCCAGGACACGCGCAGCGTGCTCGAGCCGTCCGGCGCGCTCGCGGTCGCGGGCGCGAAGCTCTACG
CGGAACGCGAAGGCATCGAGAACCAGACGCTCGTCGCGGTCACGTCCGGCGCGAACATGAACTTCGACCGGATGCGCTTC
GTCGCCGAGCGCGCGGAAGTGGGTGAAGCGCGCGAAGCCGTGTTCGCGGTCACGATCCCCGAAGAGCGCGGCAGCTTCAA
GCGCTTCTGCTCGCTCGTCGGCGATCGCAACGTCACCGAGTTCAACTACCGGATCGCCGATGCGCAGGCCGCGCACATCT
TCGTCGGCGTGCAGATCAAGCGTCGCGGCGAATCGGCCGAGATCGCCGCGAACTTCGAATCGCACGGCTTCAAGAGCGTC
GACCTGACGCACGACGAGCTGTCGAAGGAACACATCCGCTACATGGTGGGCGGCCGCTCGCCGCTCGCGCTCGACGAGCG
CCTGTTCCGCTTCGAATTCCCGGAGCGGCCGGGCGCGCTGATGAAGTTCCTGTCGTCGATGGCGCCGGACTGGAACATCA
GCCTGTTCCACTACCGCAACCAGGGCGCGGACTACAGCTCGATCCTCGTCGGGCTGCAGGTGCCGCAGGCCGATCGCGCC
GAATTCGAACGCTTCCTCGCGGCACTCGGCTATCCGTATGTCGAGGAGAGCGCCAACCCGGCTTACCGCCTCTTCCTGTC
GTAA

Upstream 100 bases:

>100_bases
CCGGCGGGCACGCGCTCGGCATGCCGCTTGCATGCAGGCGGACCCTTGGCGCTATCATTGATCTTTTACCGTCTGCTTTC
CGCACTGCACGCGAACGCCC

Downstream 100 bases:

>100_bases
AGGCGTCACGCATGAATCCCGAACATTCCCCGCTCGGCAAGGCCACCGTCTACGCCGCCCAGTACGACGCGTCGCTGCTG
TTCCCGATCCCGCGCGCCGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MASHDYLKKILTARVYDVAIETELESARILSARLRNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQEERGLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAIFVPIGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLEAGRRVELSEVGLFADGTAVKL
VGEETFRLCSEYLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKSV
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
EFERFLAALGYPYVEESANPAYRLFLS

Sequences:

>Translated_507_residues
MASHDYLKKILTARVYDVAIETELESARILSARLRNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQEERGLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAIFVPIGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLEAGRRVELSEVGLFADGTAVKL
VGEETFRLCSEYLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKSV
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
EFERFLAALGYPYVEESANPAYRLFLS
>Mature_506_residues
ASHDYLKKILTARVYDVAIETELESARILSARLRNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHA
QGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQEERGLTFVHPFDDPYVIAGQGT
IAMEILRQHQGPIHAIFVPIGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLEAGRRVELSEVGLFADGTAVKLV
GEETFRLCSEYLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRFV
AERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKSVD
LTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRAE
FERFLAALGYPYVEESANPAYRLFLS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=311, Percent_Identity=32.7974276527331, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI33469958, Length=319, Percent_Identity=27.8996865203762, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790207, Length=504, Percent_Identity=53.968253968254, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.0128617363344, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=31.5789473684211, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71991565, Length=324, Percent_Identity=29.9382716049383, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508781, Length=279, Percent_Identity=29.7491039426523, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=518, Percent_Identity=47.8764478764479, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=33.8815789473684, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=270, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=30.0632911392405, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=29.0196078431373, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55294; Mature: 55163

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHDYLKKILTARVYDVAIETELESARILSARLRNAVYLKREDNQPVFSFKLRGAYNKM
CCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHAVKVQEERGLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAIFVP
EEECCCCCHHHHHHHEEEHHHCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLEAGRRVELSEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCEEEHHHCCEEECCCEEEE
VGEETFRLCSEYLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKSVDLTHDELSKEHIRYMVGGRS
EEEEEECCCEEEEEEEEEEEECCCCCEEEECHHHCCCEEECCCHHHHHHHHHHHEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC
>Mature Secondary Structure 
ASHDYLKKILTARVYDVAIETELESARILSARLRNAVYLKREDNQPVFSFKLRGAYNKM
CCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHAVKVQEERGLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAIFVP
EEECCCCCHHHHHHHEEEHHHCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLEAGRRVELSEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCEEEHHHCCEEECCCEEEE
VGEETFRLCSEYLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKSVDLTHDELSKEHIRYMVGGRS
EEEEEECCCEEEEEEEEEEEECCCCCEEEECHHHCCCEEECCCHHHHHHHHHHHEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA