Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 78067424

GI number: 78067424

Start: 3084693

End: 3085214

Strand: Reverse

Name: purE [H]

Synonym: Bcep18194_A5955

Alternate gene names: 78067424

Gene position: 3085214-3084693 (Counterclockwise)

Preceding gene: 78067425

Following gene: 78067423

Centisome position: 83.52

GC content: 68.58

Gene sequence:

>522_bases
ATGAGTGAAATCCAGACTGCCCACACGCACAGCGCGCCGCTCGTCGGCGTGCTGATGGGATCGAGTTCCGATTGGGACGT
GATGAAGCACGCGGTTGCCATCCTGCAGGAATTCGGCGTGCCGTACGAAGCGAAGGTCGTGTCCGCGCACCGGATGCCCG
ACGAGATGTTCGACTATGCGGAGAAGGCGCGCGAGCGCGGGCTGCGCGCGATCATCGCGGGGGCCGGCGGCGCCGCGCAC
CTGCCGGGCATGCTGGCCGCGAAGACCACGGTGCCGGTGCTCGGCGTGCCGGTCGCGAGCAAGTACCTGAAGGGCGTCGA
TTCGCTGCACTCGATCGTGCAGATGCCGAAGGGCGTGCCCGTCGCGACGTTCGCGATCGGCGAGGCCGGCGCTGCGAACG
CCGCGCTGTTCGCGGTGTCGATCCTGTCCGGCAACTCGGTCGACTATGCGAACCGCCTCGCCGCGTTCCGCGTGCGCCAG
AACGAAGCCGCGCACGCGATGGTGCTGCCGCCGCTGGAATGA

Upstream 100 bases:

>100_bases
CGCTCGAGCGCATCACGGGCCAGGCGCTCGCCTGATCGGACTTTGCATGGGACCAGAGTAAGTGCTGAAGCACTAACTCT
GGTCGACAGGAACTGAACAA

Downstream 100 bases:

>100_bases
CGGCGCACCGGCGGCCGCGCGTCGCGGCTGCCTGACCTCCCCACTGCGGCGGGCAGCGCCCGCCGCGACCGATCACTGAC
ATGACCGCAACTCCTGATTC

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSEIQTAHTHSAPLVGVLMGSSSDWDVMKHAVAILQEFGVPYEAKVVSAHRMPDEMFDYAEKARERGLRAIIAGAGGAAH
LPGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVATFAIGEAGAANAALFAVSILSGNSVDYANRLAAFRVRQ
NEAAHAMVLPPLE

Sequences:

>Translated_173_residues
MSEIQTAHTHSAPLVGVLMGSSSDWDVMKHAVAILQEFGVPYEAKVVSAHRMPDEMFDYAEKARERGLRAIIAGAGGAAH
LPGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVATFAIGEAGAANAALFAVSILSGNSVDYANRLAAFRVRQ
NEAAHAMVLPPLE
>Mature_172_residues
SEIQTAHTHSAPLVGVLMGSSSDWDVMKHAVAILQEFGVPYEAKVVSAHRMPDEMFDYAEKARERGLRAIIAGAGGAAHL
PGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVATFAIGEAGAANAALFAVSILSGNSVDYANRLAAFRVRQN
EAAHAMVLPPLE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=62.7272727272727, Blast_Score=145, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=57.3333333333333, Blast_Score=171, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18127; Mature: 17996

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIQTAHTHSAPLVGVLMGSSSDWDVMKHAVAILQEFGVPYEAKVVSAHRMPDEMFDYA
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHEEHHHHCCCHHHHHHH
EKARERGLRAIIAGAGGAAHLPGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVP
HHHHHCCCEEEEECCCCHHHCCCHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCC
VATFAIGEAGAANAALFAVSILSGNSVDYANRLAAFRVRQNEAAHAMVLPPLE
EEEEECCCCCCCCHHHHEEHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCC
>Mature Secondary Structure 
SEIQTAHTHSAPLVGVLMGSSSDWDVMKHAVAILQEFGVPYEAKVVSAHRMPDEMFDYA
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHEEHHHHCCCHHHHHHH
EKARERGLRAIIAGAGGAAHLPGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVP
HHHHHCCCEEEEECCCCHHHCCCHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCC
VATFAIGEAGAANAALFAVSILSGNSVDYANRLAAFRVRQNEAAHAMVLPPLE
EEEEECCCCCCCCHHHHEEHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]