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The map label for this gene is nadC [H]

Identifier: 78067306

GI number: 78067306

Start: 2950274

End: 2951158

Strand: Reverse

Name: nadC [H]

Synonym: Bcep18194_A5837

Alternate gene names: 78067306

Gene position: 2951158-2950274 (Counterclockwise)

Preceding gene: 78067307

Following gene: 78067301

Centisome position: 79.89

GC content: 66.89

Gene sequence:

>885_bases
ATGACGAACTCCGCAGTATCCCCGCTGTTCAGCAGCGTCCGCGAGCAATACGGCGCGGCATTCGACGATGCGATCGCACG
CAACGTGGCCGATGCAATCGCGGAAGACGTCGGTGCCGGCGACCAGACCGGGCGGCTCGTACCGGCCGGCGGGCGTCGCC
GTGCTCGCATCATCGTGCGCGAGGAAGCCGTGTTGTGTGGCGTGCCGTGGTTCGAGGCCGTGATTGCACGGATCGATCCG
GAGATCGTCGTGCAATGGCACTATCGCGAAGGCGACCGGATGACGCCCGATTCGACCGTTTGCGAACTCGAAGGGCCGGC
GCGCGCGCTGCTGACGGCCGAGCGCAACGGGCTGAACTTCCTGCAGCTGCTGTCGGGCGTCGCGACCGCGACGCGTCGTT
ACGTCGATCGTGTCGAAGGCACGCGCGCGAAGATCCTCGATACGCGCAAGACGCTGCCGGGCCTGCGGCTCGCGCAGAAG
TACGCGGTGCGCGTCGGCGGCGGCGAGAACCAGCGTCTCGCGCTGTATGACGGCATCCTGATCAAGGAAAACCACATCGC
GGCGGCAGGCGGTGTCGGCGAGGCACTCGACGCGGCGTTCGCGCTGGAGTCGGGCGTGCCCGTGCAGGTCGAAGTCGAGA
CGCTTGCGCAACTCGATACGGCGCTCGCGCACCGCGCGCAGTCGGTGCTGCTCGACAACTTCACGCTCGACATGATGCGT
GAAGCGGTGCGTGTGGCTGCGGACAAGGCCGTGCTCGAAGTGTCGGGCGGCGTCAATTTCGATACGGTGCGTGCGTTCGC
GGAGACGGGTGTCGACCGCATCTCGATCGGCGCGCTGACGAAGGACGTGCGCGCGACGGACTATTCGATGCGGATCGTCG
ACTGA

Upstream 100 bases:

>100_bases
TCGACCGGATGCTCGATTTCGCAGCCGCGCACAAGAAGCGCGTGCAGGCGAGCGGTGATCTGCAACGCGATCAGCAATTG
TTTGCGAACGTGGGGGCTGC

Downstream 100 bases:

>100_bases
CCGAACGCCGTCGATCAGACAAAAAAGCCGTTGGCGCGCAAACGCCAACGGCTTTTTTCTTGTGCGGCCGCAGCCAGGAA
GGGCGTGCCGGTCAGCGGCG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTNSAVSPLFSSVREQYGAAFDDAIARNVADAIAEDVGAGDQTGRLVPAGGRRRARIIVREEAVLCGVPWFEAVIARIDP
EIVVQWHYREGDRMTPDSTVCELEGPARALLTAERNGLNFLQLLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQK
YAVRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALESGVPVQVEVETLAQLDTALAHRAQSVLLDNFTLDMMR
EAVRVAADKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD

Sequences:

>Translated_294_residues
MTNSAVSPLFSSVREQYGAAFDDAIARNVADAIAEDVGAGDQTGRLVPAGGRRRARIIVREEAVLCGVPWFEAVIARIDP
EIVVQWHYREGDRMTPDSTVCELEGPARALLTAERNGLNFLQLLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQK
YAVRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALESGVPVQVEVETLAQLDTALAHRAQSVLLDNFTLDMMR
EAVRVAADKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD
>Mature_293_residues
TNSAVSPLFSSVREQYGAAFDDAIARNVADAIAEDVGAGDQTGRLVPAGGRRRARIIVREEAVLCGVPWFEAVIARIDPE
IVVQWHYREGDRMTPDSTVCELEGPARALLTAERNGLNFLQLLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQKY
AVRVGGGENQRLALYDGILIKENHIAAAGGVGEALDAAFALESGVPVQVEVETLAQLDTALAHRAQSVLLDNFTLDMMRE
AVRVAADKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=257, Percent_Identity=34.6303501945525, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=51.4814814814815, Blast_Score=244, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6321162, Length=285, Percent_Identity=31.2280701754386, Blast_Score=145, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31705; Mature: 31574

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSAVSPLFSSVREQYGAAFDDAIARNVADAIAEDVGAGDQTGRLVPAGGRRRARIIVR
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEEE
EEAVLCGVPWFEAVIARIDPEIVVQWHYREGDRMTPDSTVCELEGPARALLTAERNGLNF
ECEEEECCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEECCCHHEEEEECCCCCHH
LQLLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGIL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEE
IKENHIAAAGGVGEALDAAFALESGVPVQVEVETLAQLDTALAHRAQSVLLDNFTLDMMR
EECCCEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVRVAADKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD
HHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCHHCCCCEEEEEC
>Mature Secondary Structure 
TNSAVSPLFSSVREQYGAAFDDAIARNVADAIAEDVGAGDQTGRLVPAGGRRRARIIVR
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEEE
EEAVLCGVPWFEAVIARIDPEIVVQWHYREGDRMTPDSTVCELEGPARALLTAERNGLNF
ECEEEECCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEEEECCCHHEEEEECCCCCHH
LQLLSGVATATRRYVDRVEGTRAKILDTRKTLPGLRLAQKYAVRVGGGENQRLALYDGIL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEE
IKENHIAAAGGVGEALDAAFALESGVPVQVEVETLAQLDTALAHRAQSVLLDNFTLDMMR
EECCCEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVRVAADKAVLEVSGGVNFDTVRAFAETGVDRISIGALTKDVRATDYSMRIVD
HHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]