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The map label for this gene is cbl [H]

Identifier: 78067276

GI number: 78067276

Start: 2921250

End: 2922191

Strand: Direct

Name: cbl [H]

Synonym: Bcep18194_A5807

Alternate gene names: 78067276

Gene position: 2921250-2922191 (Clockwise)

Preceding gene: 78067269

Following gene: 78067277

Centisome position: 79.08

GC content: 64.33

Gene sequence:

>942_bases
ATGAACCTGCACCAATTTCGCTTCGTGCGCGAGGCCGTCCGGCAGAATTTCAACCTCACCGAGGCCGCCAAGGCGCTCTA
CACGTCGCAACCGGGGGTATCGAAGGCGATCATCGAGCTCGAGGACGAGCTCGGCGTGGAGATCTTCACGCGGCACGGCA
AGCGCGTGCGCTCGCTCACCGAGCCGGGCCGGATCATCCTCGCGTCGGTCGAGCGGATTCTCCAGGAGGTTGAAAGCCTT
AAAAGGGTCGGGAAAGATTATGCAGCGCAGGATCAGGGCAACCTGACCATCGCCGCGACCCACACGCAGGCCCGCTACTC
GCTGCCGGCCGCGATCGCAGAGTTCAAGAAGCGCTTCCCGAAGGTCCACCTGTCGATCCTGCAGGGCAGCCCGACGCAGG
TGGCCGAGATGGTGATCCACGACCAGGCCGATCTCGCGATCGCGACCGAGGCGATCTCCGACTACAAGGAGCTCGTGTCG
CTGCCCTGCTTCCAGTGGCACCACGCGGCCGTCGTGCCGGCCGACCATCCGCTGCTCGAACGCAAGCCGGTCACGCTCGA
CGATCTCGCGCAGTACCCGCTGATCACGTACGAAGGCGCGTTCGCAGGCCGCAAGAAGATCAACCATGCATTCGCGCTGC
GCGGGCTGTCGCCGGACATCGTGCTCGAGGCGATCGACGCCGACGTGATCAAGACCTACGTTGAACTCGGCCTCGGCGTC
GGCATCATGGCCGACATCGCGTTCAATCCCGAGCGCGACCGCGGCCTGCGGCTGATCCCGGTCGGCCACCTGTTCGGCAG
CAACGTGACACGTGTCGCGCTCAAGCAGGGCGCCTACCTGCGCAGCTATGTGTATACGCTCGTCGAACTGCTGTCGCCGA
CACTGAACCGCAAGCTGATCGAGCAGGCGCTCAAGGGCGAATCCGAATCGTACGAACTCTGA

Upstream 100 bases:

>100_bases
AAACAGATATCCATATTTGAAAAACTCCGGTGAATCGTAATAAACTCGCCTTATATTTCAAACGACTAAAAAATTCTGTT
GATATGCGGAAGGGTTATAA

Downstream 100 bases:

>100_bases
GCGGCGTGTATAAACACGGGGGCGCACATCGCGCCCCTTTTTGCTGTCCGACGGAGAATTCCGCATGACGCTTCCCGCCC
TGTTGCGCCGCGCCGCCGCC

Product: transcriptional regulator CysB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNLHQFRFVREAVRQNFNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRVRSLTEPGRIILASVERILQEVESL
KRVGKDYAAQDQGNLTIAATHTQARYSLPAAIAEFKKRFPKVHLSILQGSPTQVAEMVIHDQADLAIATEAISDYKELVS
LPCFQWHHAAVVPADHPLLERKPVTLDDLAQYPLITYEGAFAGRKKINHAFALRGLSPDIVLEAIDADVIKTYVELGLGV
GIMADIAFNPERDRGLRLIPVGHLFGSNVTRVALKQGAYLRSYVYTLVELLSPTLNRKLIEQALKGESESYEL

Sequences:

>Translated_313_residues
MNLHQFRFVREAVRQNFNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRVRSLTEPGRIILASVERILQEVESL
KRVGKDYAAQDQGNLTIAATHTQARYSLPAAIAEFKKRFPKVHLSILQGSPTQVAEMVIHDQADLAIATEAISDYKELVS
LPCFQWHHAAVVPADHPLLERKPVTLDDLAQYPLITYEGAFAGRKKINHAFALRGLSPDIVLEAIDADVIKTYVELGLGV
GIMADIAFNPERDRGLRLIPVGHLFGSNVTRVALKQGAYLRSYVYTLVELLSPTLNRKLIEQALKGESESYEL
>Mature_313_residues
MNLHQFRFVREAVRQNFNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRVRSLTEPGRIILASVERILQEVESL
KRVGKDYAAQDQGNLTIAATHTQARYSLPAAIAEFKKRFPKVHLSILQGSPTQVAEMVIHDQADLAIATEAISDYKELVS
LPCFQWHHAAVVPADHPLLERKPVTLDDLAQYPLITYEGAFAGRKKINHAFALRGLSPDIVLEAIDADVIKTYVELGLGV
GIMADIAFNPERDRGLRLIPVGHLFGSNVTRVALKQGAYLRSYVYTLVELLSPTLNRKLIEQALKGESESYEL

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=309, Percent_Identity=46.2783171521036, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1787530, Length=304, Percent_Identity=45.3947368421053, Blast_Score=293, Evalue=8e-81,
Organism=Escherichia coli, GI157672245, Length=213, Percent_Identity=34.7417840375587, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=26.1224489795918, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1790399, Length=308, Percent_Identity=24.3506493506494, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788481, Length=247, Percent_Identity=28.3400809716599, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788887, Length=249, Percent_Identity=28.5140562248996, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789204, Length=242, Percent_Identity=26.4462809917355, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787601, Length=149, Percent_Identity=28.8590604026846, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367136, Length=234, Percent_Identity=22.2222222222222, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=186, Percent_Identity=27.4193548387097, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082132, Length=147, Percent_Identity=25.8503401360544, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787879, Length=259, Percent_Identity=25.4826254826255, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34847; Mature: 34847

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLHQFRFVREAVRQNFNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRVRSLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCHHHHHHC
EPGRIILASVERILQEVESLKRVGKDYAAQDQGNLTIAATHTQARYSLPAAIAEFKKRFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
KVHLSILQGSPTQVAEMVIHDQADLAIATEAISDYKELVSLPCFQWHHAAVVPADHPLLE
CEEEHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCC
RKPVTLDDLAQYPLITYEGAFAGRKKINHAFALRGLSPDIVLEAIDADVIKTYVELGLGV
CCCCCHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GIMADIAFNPERDRGLRLIPVGHLFGSNVTRVALKQGAYLRSYVYTLVELLSPTLNRKLI
CCEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHCHHHHHHHH
EQALKGESESYEL
HHHHCCCCCCCCC
>Mature Secondary Structure
MNLHQFRFVREAVRQNFNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRVRSLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCHHHHHHC
EPGRIILASVERILQEVESLKRVGKDYAAQDQGNLTIAATHTQARYSLPAAIAEFKKRFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
KVHLSILQGSPTQVAEMVIHDQADLAIATEAISDYKELVSLPCFQWHHAAVVPADHPLLE
CEEEHEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCC
RKPVTLDDLAQYPLITYEGAFAGRKKINHAFALRGLSPDIVLEAIDADVIKTYVELGLGV
CCCCCHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GIMADIAFNPERDRGLRLIPVGHLFGSNVTRVALKQGAYLRSYVYTLVELLSPTLNRKLI
CCEEEEEECCCCCCCEEEEEEHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHCHHHHHHHH
EQALKGESESYEL
HHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]