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The map label for this gene is pepA

Identifier: 78067266

GI number: 78067266

Start: 2910470

End: 2911981

Strand: Reverse

Name: pepA

Synonym: Bcep18194_A5797

Alternate gene names: 78067266

Gene position: 2911981-2910470 (Counterclockwise)

Preceding gene: 78067270

Following gene: 78067265

Centisome position: 78.83

GC content: 67.33

Gene sequence:

>1512_bases
ATGGACTTTAGCATAAAAGGCTGTGATTGGAGCAAAGGCGAGGCGAAGGGGTTCCTGACCGGGAAGTCCGACTGCATCGT
GCTCGGCATCTTCGAGGCGCAGACCCTGTCGGGCGCGGCGCTCGACATCGACACGGCCACCAAGGGGCTGATTTCGCGCG
TGATCAAGGCCGGCGACATGGACGGCAAGCGCGGCAAGACGCTGTTCCTGCACGAAGTGTCGGGCATCGGCGCGTCGCGC
GTGCTGCTCGTCGGCCTCGGCAAGCAGGATGCTTTCAATCAGAAAGCCTATAACGATGCCGTGACGGCCGCATGGCGCGC
GCTGCTGGCGACCAAGGTCGTCCAGGTCACGTTCACGCTCGCGCAACTGCCGGTCGACGAGCGCAGCTCCGACTGGGGCG
TGCGCGCCGCGATTCTCGCGCTGCGCAACGAGACGTACCGCTTCACGCAGATGAAGAGCAAGCCGGAACCGGCGTCGCAC
ACGCTCAAGCGCGTCGTGTTCAGCGTCGATCCGTCCGACGAAAAGGCCGCGAAGGTCGCGGTCAAGCAGGCCGTCGCGCT
CGCGAACGGGATGGATCTCACCCGCGACCTCGGCAACCTGCCGGGCAACGTCTGCACGCCGACCTACCTCGGCAACACCG
CGAAGAAGATCGCGAAGGATTGGGGCCTGAAGGCGGAAGTGCTCGGCCTCAAGCAGATCCAGGCGCTGAAGATGGGCTCG
TTCCTGTCGGTCGCGCGCGCGTCGGTCGAGCCGCCGCAGTTCATCGTGCTGCACTACCAGGGCGCCGCCGCGAAGGCCGC
GCCGGTCGTGCTGGTCGGCAAGGGCATCACGTTCGACACGGGCGGCATCTCGCTGAAGCCGGGCGAGGGCATGGACGAGA
TGAAGTACGACATGTGCGGCGCGGGTTCCGTGCTCGGCACGATGCGTGCGGTCGCCGAGATGGGCCTGAAGATCAACGTC
GTCGCGATCGTGCCGACCTGCGAGAACATGCCGGGCGGCAACGCGACGAAGCCGGGCGACATCGTCACCAGCATGAAGGG
CCTGACGATCGAGGTGCTGAACACCGACGCCGAAGGCCGTCTGATCCTGTGCGACGCGCTCACGTATGCCGAACGCTTCA
AGCCGGCCGCCGTGATCGACGTGGCCACGCTGACGGGCGCGTGCGTGATCGCGCTGGGCGGCCACAACAGCGGCCTGTTC
TCGACGGACGACGCGCTCGCGGGCGAACTGCTCGACGCGTCGCGCGAAGCGAACGACCCGGCATGGCGCATGCCGCTCGA
CGACGAGTACCAGGATCAGCTGAAGTCGAATTTCGCGGATCTCGCGAACATCGGCGGGCGCCCGGCCGGCGCCGTGACGG
CCGCGTGCTTCCTGTCGCGCTTCACCGAGAGCTATCCGTGGGCCCACCTCGACATCGCGGGCACCGCCTGGAAGGGTGGG
GCGGCGAAGGGTGCGACGGGCCGTCCGGTGCCGCTGCTCGCGCAGTTCCTGATCGACCGCGCCGGCCAGTGA

Upstream 100 bases:

>100_bases
GGCTGCGCACGCGTGGTGGAGCGCTCGCGCCGCCACGGGAAAAATAGCGGATAATTGCGGCTTTCATCCTTAGCCCAGAT
TTTATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
TGGCGGTGTTGACGACGCTGCGGGTACGCGGGCAATGACGCGAATCGATTTCCACTCGAACGTCGGCGATTCGCTCGCGT
ACGCGTGCCGGCTGCTGCGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVIKAGDMDGKRGKTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASH
TLKRVVFSVDPSDEKAAKVAVKQAVALANGMDLTRDLGNLPGNVCTPTYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINV
VAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLF
STDDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
AAKGATGRPVPLLAQFLIDRAGQ

Sequences:

>Translated_503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVIKAGDMDGKRGKTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASH
TLKRVVFSVDPSDEKAAKVAVKQAVALANGMDLTRDLGNLPGNVCTPTYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINV
VAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLF
STDDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
AAKGATGRPVPLLAQFLIDRAGQ
>Mature_503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVIKAGDMDGKRGKTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASH
TLKRVVFSVDPSDEKAAKVAVKQAVALANGMDLTRDLGNLPGNVCTPTYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINV
VAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLF
STDDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
AAKGATGRPVPLLAQFLIDRAGQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=492, Percent_Identity=38.2113821138211, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=32.8267477203647, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790710, Length=506, Percent_Identity=49.604743083004, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=41.692789968652, Blast_Score=209, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17556903, Length=321, Percent_Identity=33.9563862928349, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=249, Percent_Identity=30.5220883534137, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355725, Length=317, Percent_Identity=37.2239747634069, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI20129969, Length=523, Percent_Identity=30.5927342256214, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24661038, Length=317, Percent_Identity=36.9085173501577, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24662227, Length=374, Percent_Identity=35.0267379679144, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI161077148, Length=492, Percent_Identity=30.8943089430894, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI20130057, Length=492, Percent_Identity=30.8943089430894, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI21355645, Length=490, Percent_Identity=30.2040816326531, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24662223, Length=490, Percent_Identity=30.2040816326531, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19922386, Length=508, Percent_Identity=28.5433070866142, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI20129963, Length=510, Percent_Identity=27.2549019607843, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=32.258064516129, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=32.258064516129, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21357381, Length=312, Percent_Identity=32.0512820512821, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24646701, Length=254, Percent_Identity=30.3149606299213, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646703, Length=254, Percent_Identity=30.3149606299213, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21358201, Length=254, Percent_Identity=30.3149606299213, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53038; Mature: 53038

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVIKAGDM
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEEECHHHHHHHHHHHHHCCCC
DGKRGKTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASHTLKRVVFSVDPSDEKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHEEECCCCCHHHHHHH
VKQAVALANGMDLTRDLGNLPGNVCTPTYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCCHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHHCH
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKINVVAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLFSTDDALAGELLDASREANDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
AWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
EEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGQ
CCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVIKAGDM
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEEECHHHHHHHHHHHHHCCCC
DGKRGKTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASHTLKRVVFSVDPSDEKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHEEECCCCCHHHHHHH
VKQAVALANGMDLTRDLGNLPGNVCTPTYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCCHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHHCH
FLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTMRAVAEMGLKINVVAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLFSTDDALAGELLDASREANDP
EEEEEHHHHHHHCCCCCEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCC
AWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGG
EEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGQ
CCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA