Click here to switch to the map view.

The map label for this gene is hemD [H]

Identifier: 78067220

GI number: 78067220

Start: 2857344

End: 2859314

Strand: Reverse

Name: hemD [H]

Synonym: Bcep18194_A5751

Alternate gene names: 78067220

Gene position: 2859314-2857344 (Counterclockwise)

Preceding gene: 161702955

Following gene: 78067219

Centisome position: 77.4

GC content: 70.12

Gene sequence:

>1971_bases
ATGGCGGGCGGCGCGCGCGCGTTCACCGCTGTCCTGACGCGCCCGGACGGCCAGTCCGGCGCGCTTGCGTCGCAACTGGC
CGAGGCCGGTTGCGACGTGCTCGAATTCCCGTTGATCGACATTGCGCCGGTCGACGATCCGGCGCCGCTCGACGCGGCGT
TCGCGGCGCTCGCCGACTACACACTGGTGATTTTCGTGTCGCCGAACGCGATCGACCGCGCGCTCGCGCAGTACGGCGCG
ATCTGGCCGAACGCGCTGCCGGTCGGCGTGGTCGGGCCCGGCAGCGTCGCCGCGCTCGAGCGTCACGGCATCGCGGCGCC
CGCGCATCGCGTGATCGCGCCGCAGGCGCCGGCCGACGGTGGCGTGCCCCATTACGATTCGGAAAGCCTGTTCGCGTGCA
TCGAGACCGCATTCGGCGGCGCGCAGGCGCTGGCGGGCAAGCGCGTGCTGATCGTGCGCGGCGACGGCGGGCGCGAATGG
CTCGCCGACCGGTTGCGCGAGGCCGGCGCGGACGTCACGCTCGTCGCCGCGTACCGGCGCGTCGTGCCCGATCCGCGCGT
CGGCGCGTGGGAGCGCGTGCACGCGCTGCTCCACGGCGAGCCGCATGCGTGGCTCGTCACGAGCTCGGAAGGCGTGCGCA
ACCTGCACGAACTCGCGCGGTCGCACCTGAACGACGCCGAGATCGACGCGCTGAAGCACGCGCCGCTCGTGACGCCCCAT
CCGCGGATCGAGCAGACCGCGCGTTCATTGGGTTTTGATAGGATTACGCTGACCGGCGCGGGCGATGAGCGCATCGTCCG
CGCGTTTCGAACGATGGCCGACGAGGCCGTCCAACCGGCGACAGCCGCACCGGTGACTAAACGCATGACAGATACCAACG
ATTCCAAAAGCGTCGCTTCCCAGCCGGCCGCTGCATCCGCACCGCCGTCCCGTCCCGCCTATATGGGCGCCGAACCGCCT
GCGCGCCGCGGCGGCAGCGCGGTGCTGTGGTTCGTCGTCGTCGTGCTCGGCTGCGCGGCGGGCGTCGGCGGCTACGCGCT
GAACCGCAAGATCGACAGGCTCGACGGCACGTTCGTCACGCGCCAGAAGGCGCTCGATGCGCAGACCGCCGAGACGCGCC
TGAAGACCGAGCAGGCGCTCGCGAGCACGCACCAGGTCGACACGCAGCTCGCGCAGCTCGACGGCAAGCTCGCCGACGCG
CAGAGCGCGCAGCAGGCGCTGCAGCAGCAATATCAGGACCTGTCGCGTAACCGCGATGCGTGGATGCTCGAGGAAGTCGA
CCAGATGCTGTCGAGCGCGAGCCAGCAGCTTCAGCTGACCGGCAACACGCAGCTCGCGCTGATCGCGCTGCAGAACGCCG
ACGCACGCCTCGCAACGTCGCAAAGCGCGCAGGCCGTCACGGTGCGCAAGGCGCTCGCGCTGGACATCGAGAAGCTGAAG
GCCGCACCGGCGGCCGACCTCACGGGCCTTGCGATCAAGCTCGACGATGCCATTGCGAAGATCGACGCGCTGCCGCTGTC
CGGCGAGGCGATCGTCCCGCACGAAGCGCCGAAGGCCGCACCGGCCGACGCCGCGTCGTCGGCCGTGGCCGGCGAGCCGC
GCTGGAAGGTGTGGTGGCATGACTTCTCGGCCGGCCTTGGCCAGCAGTTGAAGGGGCTCGTGCAGGTGCGTCGCATTGAC
AACGCGGACGCGATGCTCGCGTCGCCCGACCAGGGCTCCTTCGTGCGCGAGAACGTGAAGCTGCGCCTGCTGACCGCGCG
CCTGTCGCTGCTCGCGCGCAACGACAGCGCGATGAAGGCCGACCTGCACGCTGCGCAGGCGTCGCTCGGGAAGTATTTCG
ACCAGGCCTCGAAGGATACGCAGACCGTCGAGGATCTGCTCAAGCAGGTTGACGGCGCATCGCTGACGGTTGCGGTGCCG
AACCTGAACACGAGCCTGAACGCCGTTCAGCAGTTCAAGAGCCGGGGGTAA

Upstream 100 bases:

>100_bases
TCGGCCGCGCCGTGTCCGACGAACTCGAGGCGCAAGGCGCGCTCGACATCGTCCAGGCGCTGCTCGCGGGCTCGCCGCCC
GCCGGCAAGGGCGACGCCTG

Downstream 100 bases:

>100_bases
CGATGACGCTTCGAGGAATCGTCTGGCTCGCGGTCCTGTTCGCGATCGCCGCTGCGCTCGCCACGGTTGGCCGTTTCGAC
GCGGGGCAGGTGCTGCTCGT

Product: bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MAGGARAFTAVLTRPDGQSGALASQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALADYTLVIFVSPNAIDRALAQYGA
IWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDSESLFACIETAFGGAQALAGKRVLIVRGDGGREW
LADRLREAGADVTLVAAYRRVVPDPRVGAWERVHALLHGEPHAWLVTSSEGVRNLHELARSHLNDAEIDALKHAPLVTPH
PRIEQTARSLGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVASQPAAASAPPSRPAYMGAEPP
ARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDGTFVTRQKALDAQTAETRLKTEQALASTHQVDTQLAQLDGKLADA
QSAQQALQQQYQDLSRNRDAWMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALALDIEKLK
AAPAADLTGLAIKLDDAIAKIDALPLSGEAIVPHEAPKAAPADAASSAVAGEPRWKVWWHDFSAGLGQQLKGLVQVRRID
NADAMLASPDQGSFVRENVKLRLLTARLSLLARNDSAMKADLHAAQASLGKYFDQASKDTQTVEDLLKQVDGASLTVAVP
NLNTSLNAVQQFKSRG

Sequences:

>Translated_656_residues
MAGGARAFTAVLTRPDGQSGALASQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALADYTLVIFVSPNAIDRALAQYGA
IWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDSESLFACIETAFGGAQALAGKRVLIVRGDGGREW
LADRLREAGADVTLVAAYRRVVPDPRVGAWERVHALLHGEPHAWLVTSSEGVRNLHELARSHLNDAEIDALKHAPLVTPH
PRIEQTARSLGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVASQPAAASAPPSRPAYMGAEPP
ARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDGTFVTRQKALDAQTAETRLKTEQALASTHQVDTQLAQLDGKLADA
QSAQQALQQQYQDLSRNRDAWMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALALDIEKLK
AAPAADLTGLAIKLDDAIAKIDALPLSGEAIVPHEAPKAAPADAASSAVAGEPRWKVWWHDFSAGLGQQLKGLVQVRRID
NADAMLASPDQGSFVRENVKLRLLTARLSLLARNDSAMKADLHAAQASLGKYFDQASKDTQTVEDLLKQVDGASLTVAVP
NLNTSLNAVQQFKSRG
>Mature_655_residues
AGGARAFTAVLTRPDGQSGALASQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALADYTLVIFVSPNAIDRALAQYGAI
WPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDSESLFACIETAFGGAQALAGKRVLIVRGDGGREWL
ADRLREAGADVTLVAAYRRVVPDPRVGAWERVHALLHGEPHAWLVTSSEGVRNLHELARSHLNDAEIDALKHAPLVTPHP
RIEQTARSLGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVASQPAAASAPPSRPAYMGAEPPA
RRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDGTFVTRQKALDAQTAETRLKTEQALASTHQVDTQLAQLDGKLADAQ
SAQQALQQQYQDLSRNRDAWMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALALDIEKLKA
APAADLTGLAIKLDDAIAKIDALPLSGEAIVPHEAPKAAPADAASSAVAGEPRWKVWWHDFSAGLGQQLKGLVQVRRIDN
ADAMLASPDQGSFVRENVKLRLLTARLSLLARNDSAMKADLHAAQASLGKYFDQASKDTQTVEDLLKQVDGASLTVAVPN
LNTSLNAVQQFKSRG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=275, Percent_Identity=28.7272727272727, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790235, Length=294, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 69386; Mature: 69255

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGARAFTAVLTRPDGQSGALASQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALADY
CCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEECCCEEEECCCCCCCHHHHHHHHHCC
TLVIFVSPNAIDRALAQYGAIWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADG
EEEEEECCCHHHHHHHHHCCCCCCCCEECEECCCCHHHHHHCCCCCCCHHEECCCCCCCC
GVPHYDSESLFACIETAFGGAQALAGKRVLIVRGDGGREWLADRLREAGADVTLVAAYRR
CCCCCCCHHHHHHHHHHCCCHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEHHHHH
VVPDPRVGAWERVHALLHGEPHAWLVTSSEGVRNLHELARSHLNDAEIDALKHAPLVTPH
HCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
PRIEQTARSLGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVAS
CHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHC
QPAAASAPPSRPAYMGAEPPARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDGTFVT
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCHHHHCCCCHHH
RQKALDAQTAETRLKTEQALASTHQVDTQLAQLDGKLADAQSAQQALQQQYQDLSRNRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
WMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALALDIEKLK
HHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHC
AAPAADLTGLAIKLDDAIAKIDALPLSGEAIVPHEAPKAAPADAASSAVAGEPRWKVWWH
CCCCCCCCEEEEEECHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHCCCCCCCEEEEEE
DFSAGLGQQLKGLVQVRRIDNADAMLASPDQGSFVRENVKLRLLTARLSLLARNDSAMKA
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHCCCEEEEHHHHHHHHHCCCCHHHH
DLHAAQASLGKYFDQASKDTQTVEDLLKQVDGASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AGGARAFTAVLTRPDGQSGALASQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALADY
CCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEECCCEEEECCCCCCCHHHHHHHHHCC
TLVIFVSPNAIDRALAQYGAIWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADG
EEEEEECCCHHHHHHHHHCCCCCCCCEECEECCCCHHHHHHCCCCCCCHHEECCCCCCCC
GVPHYDSESLFACIETAFGGAQALAGKRVLIVRGDGGREWLADRLREAGADVTLVAAYRR
CCCCCCCHHHHHHHHHHCCCHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEHHHHH
VVPDPRVGAWERVHALLHGEPHAWLVTSSEGVRNLHELARSHLNDAEIDALKHAPLVTPH
HCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
PRIEQTARSLGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVAS
CHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHC
QPAAASAPPSRPAYMGAEPPARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDGTFVT
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCHHHHCCCCHHH
RQKALDAQTAETRLKTEQALASTHQVDTQLAQLDGKLADAQSAQQALQQQYQDLSRNRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
WMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALALDIEKLK
HHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHC
AAPAADLTGLAIKLDDAIAKIDALPLSGEAIVPHEAPKAAPADAASSAVAGEPRWKVWWH
CCCCCCCCEEEEEECHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHCCCCCCCEEEEEE
DFSAGLGQQLKGLVQVRRIDNADAMLASPDQGSFVRENVKLRLLTARLSLLARNDSAMKA
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHCCCEEEEHHHHHHHHHCCCCHHHH
DLHAAQASLGKYFDQASKDTQTVEDLLKQVDGASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]