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The map label for this gene is parC [H]

Identifier: 78067167

GI number: 78067167

Start: 2805121

End: 2807442

Strand: Reverse

Name: parC [H]

Synonym: Bcep18194_A5698

Alternate gene names: 78067167

Gene position: 2807442-2805121 (Counterclockwise)

Preceding gene: 78067168

Following gene: 78067166

Centisome position: 76.0

GC content: 66.75

Gene sequence:

>2322_bases
ATGGACGACAACACTTCCGATCTCTTCGCCAGCTCCGATGCACCGGACGCCGAAGCGCTGACGCTCGGCAACTACGCGGA
GCAGGCGTACCTCAGCTACGCGGTCAGCGTCGTGAAGAGCCGCGCGCTGCCCGACGTGTGCGACGGCCAGAAGCCGGTGC
AGCGCCGGATCCTGTTCGCGATGAACGAAATGGGCCTCGGCCCGGACGCGAAGCCGGTGAAATCGGCGCGCGTGGTCGGC
GACGTGCTCGGTAAATACCACCCGCACGGCGACCAGTCGGCGTACGACGCACTGGTGCGTCTCGCGCAGGATTTCTCGCT
GCGCTACCCGCTGATCGACGGGCAGGGCAACTTCGGCTCGCGCGACGGCGACGGCGCCGCGGCGATGCGATACACCGAAG
CACGCCTCACGCCGATCGCGAAGCTGCTGCTCGACGAAATCGACCAGGGCACGGTCGACTTCATGCCGAACTACGACGGC
TCGTTCGAGGAGCCGAAGACGCTGCCGAGTCGCATGCCGTTCGTGCTGCTGAACGGCGCGTCGGGCATCGCGGTCGGTCT
TGCGACCGAAATCCCGTCGCACAACCTGCGTGAAGTCGCGGCGGCGGCCGTCACGCTGATCCGCAATCCGAAGCTTTCGC
ACGCGGAGTTGATGAACCTGATTCCCGGCCCGGATTTCCCGGGCGGCGGCCAGATCATCTCGAGCGACACCGAAATCGCG
GCGGCCTATGAAACCGGCCGCGGCAGCCTGAAGGTGCGCGCGCGCTGGAAGATCGAGGATCTCGCACGCGGCCAGTGGCA
GCTCGTCGTCACCGAGCTGCCGCCGAACACGTCGGGGCAGAAGGTGCTCGAGGAAATCGAGGAACTGACGAACCCGAAGC
TCAAGCTCGGCAAGAAGACGCTGACGCCCGAGCAGCTCAACACGAAGAAGGCGATGCTCGACCTGCTCGACGCGGTGCGC
GACGAGTCGGGCAAGGAAGCGGCGGTGCGGCTCGTGTTCGAGCCGAAGTCGCGCACGATCGACCAGACGGAATTCGTGAA
CACGCTGCTCGCGTACACGAGCCTCGAATCGAACGCGACACTGAACCTCGTGATGATCGGCGCCGACGGCCGGCCGGGCC
AGAAGGGCCTGCTGACGATCCTCGACGAGTGGGTGAAGTTCCGCCAGCTGACGATGACGCGCCGGTGCCGCCATCGTCTC
GCGAAGGTCGACGACCGCATCCACATCCTCGAAGGGCGGATGATCGTCTTCCTGAACATCGACGAGGTGATCCGCATCAT
CCGCGAGTCGGACGAGCCGAAGTCCGCGTTGATGAGCGCGTTCGGTCTCAGCGAACGGCAGGCGGAAGACATCCTCGAAA
TCCGGCTGCGCCAGCTCGCGCGGCTCGAGAAGATCAAGATCGAGAAGGAACTCGAAGCGCTGCGCGACGAAAAGGCGAAG
CTCGAGGAACTGCTCGCGAACGAAAGCGCGATGAAGCGGCTGATGATCAAGGAGATCGAGGCCGATGCGAAGCAGTACGG
CGACGATCGCCGCACGCTGATCCAGCAGGAAAAGCGCGCGACGTTCGAGGCGAAGGTGGTCGACGAGCCGGTGACGGTGG
TGGTGTCGCAGAAGGGCTGGGTGCGTGCGCTGAAGGGCCACGGACTCGACCCGGCCAGCTTCTCGTTCAAGGCCGGTGAC
CATCTGTACGCGGCGTTCCAGTGCCGCACGCCGGACCGCCTGATCGCGTGGGGCAGCAGCGGCCGCGTGTACTCGGTGGA
CGTGTCGGTGCTGCCGGGCGGGCGCGGTGACGGCGTGCCCGTCACGTCGCTGATCGAGCTCGAATCGGGCTCGCACCTGA
TGCACTACTTCGCGGCACCGGCCGACCAGCAACTGCTGCTCGCGTCGAGCAACGGCTTCGGCTTCCTCGCGAAGGTCGGC
GACATGGTGAGCCGCGTGAAGGCCGGCAAGGCGTTCATGACGATCGATGCGGGCGCGGTGCCGCTCGCGCCGATGCCCGT
GCTGCCGAACGCCACGCAGGTCGCGTGCCTGTCGAGCGGCGGCCGCCTGCTCGTGTTCGGGATGGACGAGATGAAGACGC
TGTCCGGCGGCGGGCGCGGCGTGATCCTGATGGCGCTCGACGACAAGGAGACGCTCGTTCAGGCGCTCGCGATCGATCCG
GCCGGCGTTGTGCTGATCGGCACCGGTCGCGGCGGCAAGGCGATGGACGAGACGCTGTCGTATGCGGGGCTGGCGCCGCA
CGTCGGCAAGCGCGCACGCAAGGGCCGCGCGCCGGACACGAAGCTCAAGGTCGTCAGCGAACTGCGTCCGCTGCTCGGCT
GA

Upstream 100 bases:

>100_bases
AAAGGGCAACGACGTCGAAGCGGACATCTAAGCCGAACACCTGCGCGGCCGGGCCTGACGCCCGGCCCGGCCTCACGCCA
CTTACGAATACGGAATTCAG

Downstream 100 bases:

>100_bases
CGCCGCACCCGTTAGATCGTCCGGCTCGGCCGCGATCGAAGGCCGCACCTCCGCTTCGGCGGACGTGCGGCCTTTTCTTT
TGGAGGGGGATTCGGGTAAG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MDDNTSDLFASSDAPDAEALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVTLIRNPKLSHAELMNLIPGPDFPGGGQIISSDTEIA
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRL
AKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKSALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELEALRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFSFKAGD
HLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYFAAPADQQLLLASSNGFGFLAKVG
DMVSRVKAGKAFMTIDAGAVPLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
AGVVLIGTGRGGKAMDETLSYAGLAPHVGKRARKGRAPDTKLKVVSELRPLLG

Sequences:

>Translated_773_residues
MDDNTSDLFASSDAPDAEALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVTLIRNPKLSHAELMNLIPGPDFPGGGQIISSDTEIA
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRL
AKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKSALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELEALRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFSFKAGD
HLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYFAAPADQQLLLASSNGFGFLAKVG
DMVSRVKAGKAFMTIDAGAVPLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
AGVVLIGTGRGGKAMDETLSYAGLAPHVGKRARKGRAPDTKLKVVSELRPLLG
>Mature_773_residues
MDDNTSDLFASSDAPDAEALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVTLIRNPKLSHAELMNLIPGPDFPGGGQIISSDTEIA
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRL
AKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKSALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELEALRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPASFSFKAGD
HLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYFAAPADQQLLLASSNGFGFLAKVG
DMVSRVKAGKAFMTIDAGAVPLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
AGVVLIGTGRGGKAMDETLSYAGLAPHVGKRARKGRAPDTKLKVVSELRPLLG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=275, Percent_Identity=29.0909090909091, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI19913406, Length=187, Percent_Identity=32.620320855615, Blast_Score=90, Evalue=9e-18,
Organism=Escherichia coli, GI1789396, Length=749, Percent_Identity=45.7943925233645, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=766, Percent_Identity=34.2036553524804, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=393, Percent_Identity=26.972010178117, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17535065, Length=198, Percent_Identity=32.3232323232323, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI212645657, Length=172, Percent_Identity=33.7209302325581, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI115534553, Length=194, Percent_Identity=29.3814432989691, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=248, Percent_Identity=29.8387096774194, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136538, Length=256, Percent_Identity=28.90625, Blast_Score=93, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84140; Mature: 84140

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNTSDLFASSDAPDAEALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFA
CCCCCCCCEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MNEMGLGPDAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGS
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDGSFEEPKTLPSRMPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVTLIRNPKLSHAELMNLIPGPDFPGGGQIISSDTEIA
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEE
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKLKLGKKT
EEEECCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCC
LTPEQLNTKKAMLDLLDAVRDESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCE
LNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRLAKVDDRIHILEGRMIVFLNI
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEH
DEVIRIIRESDEPKSALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELEALRDEKAK
HHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPASFSFKAGDHLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVP
HHHHHCCCCCCCCCEECCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCC
VTSLIELESGSHLMHYFAAPADQQLLLASSNGFGFLAKVGDMVSRVKAGKAFMTIDAGAV
EEEEEEECCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
PLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
CCCCCCCCCCCCEEEEECCCCEEEEEECHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCC
AGVVLIGTGRGGKAMDETLSYAGLAPHVGKRARKGRAPDTKLKVVSELRPLLG
CCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDDNTSDLFASSDAPDAEALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFA
CCCCCCCCEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MNEMGLGPDAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGS
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDGSFEEPKTLPSRMPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVTLIRNPKLSHAELMNLIPGPDFPGGGQIISSDTEIA
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEE
AAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSGQKVLEEIEELTNPKLKLGKKT
EEEECCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCC
LTPEQLNTKKAMLDLLDAVRDESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCE
LNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRLAKVDDRIHILEGRMIVFLNI
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEH
DEVIRIIRESDEPKSALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELEALRDEKAK
HHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPASFSFKAGDHLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVP
HHHHHCCCCCCCCCEECCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCC
VTSLIELESGSHLMHYFAAPADQQLLLASSNGFGFLAKVGDMVSRVKAGKAFMTIDAGAV
EEEEEEECCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCC
PLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
CCCCCCCCCCCCEEEEECCCCEEEEEECHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCC
AGVVLIGTGRGGKAMDETLSYAGLAPHVGKRARKGRAPDTKLKVVSELRPLLG
CCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]