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The map label for this gene is nuoL [H]

Identifier: 78067035

GI number: 78067035

Start: 2663148

End: 2665202

Strand: Reverse

Name: nuoL [H]

Synonym: Bcep18194_A5566

Alternate gene names: 78067035

Gene position: 2665202-2663148 (Counterclockwise)

Preceding gene: 78067036

Following gene: 78067034

Centisome position: 72.15

GC content: 62.63

Gene sequence:

>2055_bases
ATGTCAACGACACTCAATGAAAACCTGCTGCTGGCGATTCCGCTCGCTCCGCTGGCCGGCTCGCTGATTGCGGGGCTGTT
CGGGAACGCAGTCGGGCGCAAGGGCGCACACCGGATCACGATCCTCGGCGTAATGATCGCGTTCCTCCTGTCGGCGAAAG
TCTTCTTCGACGTGATGGGCGGCGCAAGCTTCAACGCGACCGTCTACGAATGGATGAACGTCGGCTCGCTGAAGCTCGAA
GTCGGCTTCCTCGTCGATTCGCTGACCGCGATGATGATGGTCGTCGTGACCTTCGTCTCGCTGATGGTGCACGTGTACAC
GATCGGCTACATGGCGGAAGAAGACGGCTACCAGCGCTTCTTCTCGTACATCTCGCTGTTCACGTTCTCGATGCTGATGC
TCGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGTCTGGTGTCGTACCTGCTGATCGGCTTC
TACTTCACGCGTGAGAGCGCGATCTACGCGAACATGAAGGCGTTCCTCGTGAACCGCGTGGGCGACTTCGGCTTCCTGCT
CGGCATCGGCCTGCTGCTCGCATTCGCCGGCTCGATGAACTACGGCGAAGTGTTCGCAAAGCGCGCGGAACTCGCGAGCC
TGCACTTCCCGGGCACCGACTGGGGCCTGCTGACCGTTGCCTGTATCTGCCTGTTCATCGGCGCGATGGGCAAGTCGGCA
CAGTTCCCGCTGCACGTGTGGCTGCCGGACTCGATGGAAGGCCCGACCCCGATCTCCGCGCTGATTCACGCGGCGACGAT
GGTGACCGCCGGCATCTTCATGGTGTCGCGCATGTCGCCGCTGTTCGAACTGTCGGATACCGCGCTGTCGTTCATCACGG
TGATCGGCGCGATCACGGCGCTCTTCATGGGCTTCCTCGGCATCGTCCAGAACGACATCAAGCGCGTGGTTGCGTACTCG
ACGCTGTCGCAGCTCGGCTACATGACCGTCGCGCTCGGCGTGTCCGCTTACCCGGTCGCCGTGTTTCACCTGATGACGCA
CGCGTTCTTCAAGGCACTGCTGTTCCTTGGCGCAGGCTCGGTCATCATGGGCATGCACCACGACCAGGACATGCGCAACA
TGGGTGGCCTGCGCAAGTACATGCCGATCACGTGGATCACGTCGCTCGTCGGTTCGCTCGCGCTGATCGGCACGCCGTTC
TTCTCGGGCTTCTACTCGAAGGACTCGATCATCGACGCGGTGAAGCTGTCGCACCTGCCGGGTTCGGGCTTCGCGTACTT
CGCGGTCGTCGCGAGCGTGTTCGTCACGGCGCTGTACTCGTTCCGCATGTACTTCCTGGTGTTCCACGGCGAAGAGCGCT
TCCGCAAGCCGAAGCATCCGGAATCGCCGATGGGCATGGCGGCTGCGCATGGCCACGACGACCACGGCCACGGCCACGGT
CATGACGACCACGCGCACGAACCGCACGAGACCCCGTGGGTCGTGTGGGTGCCGCTGGTCCTGCTGGCGATCCCGTCAGT
CATCATCGGCGCGTTCGCGATCAGCCCGATGCTGTTCGGCGACTTCTTCCAGCACGGCGTTGCATTCGACAAGGTGATCT
TCATCGGCGAAAACCATCCGGCCCTGGCCGAGATGGCCGAAGAGTTCCACGGCTGGGTGGGCATGGGCCTGCACTCGGTG
TCGGGCCTGCCGGTCTGGCTCGCGCTCGCCGGTGTCGTTGTCGCGTGGTTCCTGTACCTGAAGCGTCCGGAACTGCCGGC
GTCGATCCGCCGCGCGTTCGGCCCGATCTACACGCTGCTGGACAACAAGTACTACATGGACAAGATCAACGAAGTGGTGT
TCGCCCGTGGTTCGGTGGCGATCGGCCGCGGCCTGTGGAAGGAGGGTGACGTCGTGGTGATCGACGGCCTCGTCAACGGC
AGCGCCCGGTTCATCGGCTGGTTCGCCGGCGTGATCCGCTTCCTCCAATCCGGTTACATCTATCACTACGCGTTCGCCAT
GATCATCGGCATGCTGGGGCTCCTGACCCTGTTTGTAACGCTCGGCGGCAAATAA

Upstream 100 bases:

>100_bases
CGATCGGCCTCGCGATTCTGGTGACCCTGTTCCGTAAGCTCGACACGATCAATGTCGAGGATCTCGATCAGCTCAAAGGT
TAATTTCAGGCAACGCTGTT

Downstream 100 bases:

>100_bases
GGCGGGGGACAACTTAATGCACGCTTTTCCGATTCTCAGTACCGCGATCTGGTTGCCGATCGTTTTCGGCCTCCTCGTGC
TTGCGGTGGGTAACGACAAA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVMIAFLLSAKVFFDVMGGASFNATVYEWMNVGSLKLE
VGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAFAISPMLFGDFFQHGVAFDKVIFIGENHPALAEMAEEFHGWVGMGLHSV
SGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNG
SARFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Sequences:

>Translated_684_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVMIAFLLSAKVFFDVMGGASFNATVYEWMNVGSLKLE
VGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAFAISPMLFGDFFQHGVAFDKVIFIGENHPALAEMAEEFHGWVGMGLHSV
SGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNG
SARFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK
>Mature_683_residues
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVMIAFLLSAKVFFDVMGGASFNATVYEWMNVGSLKLEV
GFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFY
FTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSAQ
FPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYST
LSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFF
SGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHGH
DDHAHEPHETPWVVWVPLVLLAIPSVIIGAFAISPMLFGDFFQHGVAFDKVIFIGENHPALAEMAEEFHGWVGMGLHSVS
GLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGS
ARFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=386, Percent_Identity=40.4145077720207, Blast_Score=288, Evalue=8e-78,
Organism=Escherichia coli, GI1788614, Length=617, Percent_Identity=38.2495948136143, Blast_Score=355, Evalue=5e-99,
Organism=Escherichia coli, GI1788829, Length=416, Percent_Identity=29.0865384615385, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788831, Length=352, Percent_Identity=30.1136363636364, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1788827, Length=464, Percent_Identity=28.0172413793103, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI2367154, Length=125, Percent_Identity=36, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788613, Length=332, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693160, Length=318, Percent_Identity=24.5283018867925, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74896; Mature: 74765

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVMIAFLLSAKVFFDVMG
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMNVGSLKLEVGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRF
CCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
VIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
HEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCHHCCCCCCCCCCCC
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAFAISPMLFGDFFQHGVAFDKVIFIGENHP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
ALAEMAEEFHGWVGMGLHSVSGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLL
HHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYI
CCCHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
YHYAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVMIAFLLSAKVFFDVMG
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMNVGSLKLEVGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRF
CCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
VIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
HEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCHHCCCCCCCCCCCC
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAFAISPMLFGDFFQHGVAFDKVIFIGENHP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
ALAEMAEEFHGWVGMGLHSVSGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLL
HHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYI
CCCHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
YHYAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]