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The map label for this gene is hmrR [H]

Identifier: 78067014

GI number: 78067014

Start: 2638219

End: 2638638

Strand: Reverse

Name: hmrR [H]

Synonym: Bcep18194_A5545

Alternate gene names: 78067014

Gene position: 2638638-2638219 (Counterclockwise)

Preceding gene: 78067019

Following gene: 78067013

Centisome position: 71.43

GC content: 61.67

Gene sequence:

>420_bases
ATGGAGAGGGCGGGAATGAATATCGGCGACGCGTCGCGCGAATCCGGAGTCAGCGCAAAGATGATCCGGTACTACGAACA
GGTCGGTCTGCTCGCGCCGAGCAAGCGTACCGACGCCGGCTACCGGATCTACGGTGCGGACGAGATCCATATCCTGCGCT
TCATCCGTCAGGCGCGACGCCTTGGCTTTCTCGTCGAGGACATCCGCAAGCTACTGATGCTCTGGCAAGACCGCTCCCGC
GCGAGCGCCGAAGTGAAGTCGATTGCCCTCGAGCATGTGGCCGAACTCGACAAGCGCATCGCCGAGCTGAGCGACATGCG
CGACACACTGGCCGATCTTGCTGCGCACTGCCATGGTGACGGACGGCCCGAATGCCCGATTTTGGCGCGTCTTTCTGACC
CCGTTGGTGAACCAAATTAG

Upstream 100 bases:

>100_bases
CAGTCACGCCTTACTCCGGAACGAAACCACGCGATTTGATACGATCGACGTGCCGTCGGCGATTGCACGAGTCGACGTTC
ATGTTCGAAACCAGGGCTTG

Downstream 100 bases:

>100_bases
TGCGCGCACTCGAGGCTCAAATCAGGCCTCGATTCGATTTTTATAAAAATCAATGAGTTACGACGCTTCGGAGGGCGGTC
ATTCCAATTGGGAATGGTTT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MERAGMNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGADEIHILRFIRQARRLGFLVEDIRKLLMLWQDRSR
ASAEVKSIALEHVAELDKRIAELSDMRDTLADLAAHCHGDGRPECPILARLSDPVGEPN

Sequences:

>Translated_139_residues
MERAGMNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGADEIHILRFIRQARRLGFLVEDIRKLLMLWQDRSR
ASAEVKSIALEHVAELDKRIAELSDMRDTLADLAAHCHGDGRPECPILARLSDPVGEPN
>Mature_139_residues
MERAGMNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGADEIHILRFIRQARRLGFLVEDIRKLLMLWQDRSR
ASAEVKSIALEHVAELDKRIAELSDMRDTLADLAAHCHGDGRPECPILARLSDPVGEPN

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=44.0944881889764, Blast_Score=115, Evalue=1e-27,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15604; Mature: 15604

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAGMNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGADEIHILRFIRQARR
CCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHH
LGFLVEDIRKLLMLWQDRSRASAEVKSIALEHVAELDKRIAELSDMRDTLADLAAHCHGD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRPECPILARLSDPVGEPN
CCCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MERAGMNIGDASRESGVSAKMIRYYEQVGLLAPSKRTDAGYRIYGADEIHILRFIRQARR
CCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHH
LGFLVEDIRKLLMLWQDRSRASAEVKSIALEHVAELDKRIAELSDMRDTLADLAAHCHGD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GRPECPILARLSDPVGEPN
CCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]