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The map label for this gene is phr [H]

Identifier: 78066957

GI number: 78066957

Start: 2575114

End: 2576670

Strand: Reverse

Name: phr [H]

Synonym: Bcep18194_A5488

Alternate gene names: 78066957

Gene position: 2576670-2575114 (Counterclockwise)

Preceding gene: 78066960

Following gene: 78066954

Centisome position: 69.75

GC content: 70.91

Gene sequence:

>1557_bases
GTGTGCGTCGCACGTCGACACCACGCAGCGCAGCCGCGACAATACGTGTCTCTTTCCGCTTTCGTCATCGAGGTGCCTGT
GCCCGCCAAGTCGTCCGTTGCTCCCGCGATCGTCTGGTTCCGCGACGATCTGCGCGTGACCGACCAGCCCGCGCTGACGC
GCGCGGTGGAATCGGGCCGGCCGCTCGTGTGCGTATTCGTCGACGACACGGGCGACGGCGCGGGGCGAGCGCTCGGCGGC
GCGGCGCGCTGGTGGCTGCACGGGTCGCTGGCGGGGCTCGATGCGGCGCTCGCGCGTCATGGCGGGCGCCTGCTGCTGTT
GCGTGGCGACGCGCAGCGCGAGATCGAGCGCGTCGTGCACGACACGGGCGCGGAAGCCGTGTACTGGAACCGCCGCTATG
CGCAACCGCAGCGCGACGCCGATGCGGCGCTGAAGGCGTCGCTCAAGGCGCGTGGTGTGACGGTCGAGAGCAGCAACGGC
AGCCTGCTGAACGAGCCCTGGGAAGTGCTGACAGGCAGCGGCGGCCCGTATCAGGTGTTCACGGCCTACTGGCGTGCGGC
GCGTCGCGACCGCACGGTCGCCGTGCCGCTGCCGGAACCCGAGCGGATCGCGTTTCATCCGTGGCCGAAAGCCGTGCGTG
ACTGCGCGCTGGCGCTCGACGTGCTTGCTTTGCGTCCGCCGGTGCCGGATTGGGCCGGCGGCCTGCGCGACGCGTGGCCC
GCGCCCGACGAAGCTGGCGCGCACGCCCGGCTCGACGCATTCCTGACGGCATCGCTCGCCGGCTATGCGGATGCGCGCGA
CCTTCCCGACCGTCCCGCGACGAGCCGGCTGTCGCCGTTCCTGCGCTTTGGCAACCTGTCGCCGCGACAGGTGTGGCATG
CGGTGCAGGGTGCCGCGAACGCAGGCGGCGCGGCGGTGGCCGCGGACGCCGACAAATTCCTGAGCGAGCTCGGCTGGCGC
GAGTTCAGCTACACGCTGCTGTATCACTTCCCGGCGCTCGCCAGCGACAACTTCCGCGCGCAATTCGATGCGATGCCGTG
GCGCGACGATCCCGCCGCGCTGCGTGCATGGCAGCGCGGGCGGACCGGCTATCCGCTCGTCGATGCGGGCCTGCGCGAAC
TGTGGACGACCGGCTGGATGCACAACCGCGTGCGGATGGTCGTCGCGTCGTTCCTGATCAAGCATTTGCTGATCGACTGG
CGCGCGGGCGAAGCGTGGTTCTGGGACACGCTGGTCGACGCCGATCCCGCGAACAACGCGGCGAGCTGGCAGTGGGTGGC
CGGTTGCGGTGCCGACGCCGCGCCGTATTTCCGCATCTTCAATCCGGTCGCACAGGGGCAGAAGTTCGATCCGGACGGTG
CGTACGTGCGGCGCTGGGTGCCCGAGCTTGCCGGCCTCGACAACGCATCGATCCACGCGCCGTGGGAAGCATCGCCGCTG
GAACTCGACGCGGCCGGCGTGCGGCTCGGCGTCGACTATCCGGCACCGCTCGTCGAGCATGCGGCCGCGCGTGCCCGTGC
GCTCGATGCGTTGGCGGCATTGCCGAAGCGCCGCTGA

Upstream 100 bases:

>100_bases
ACGCGGCGAAGAATCGTCGGAATGGACTAAGGCGTTTCACCGGGGCAGCAGGGCGGTGCGATTGCCGTGACGGCCGGCGG
CATGGGCGCGCCGGCGCGCC

Downstream 100 bases:

>100_bases
CCGCACGCTCCGGGCTGTCGCATCAATTGCAGAACGCGACGTGTTCGAGCAGCGCGTACGCGACGCCCGAACTGAAATAG
GCCGCGCCGCACCATGCGAC

Product: deoxyribodipyrimidine photo-lyase type I

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MCVARRHHAAQPRQYVSLSAFVIEVPVPAKSSVAPAIVWFRDDLRVTDQPALTRAVESGRPLVCVFVDDTGDGAGRALGG
AARWWLHGSLAGLDAALARHGGRLLLLRGDAQREIERVVHDTGAEAVYWNRRYAQPQRDADAALKASLKARGVTVESSNG
SLLNEPWEVLTGSGGPYQVFTAYWRAARRDRTVAVPLPEPERIAFHPWPKAVRDCALALDVLALRPPVPDWAGGLRDAWP
APDEAGAHARLDAFLTASLAGYADARDLPDRPATSRLSPFLRFGNLSPRQVWHAVQGAANAGGAAVAADADKFLSELGWR
EFSYTLLYHFPALASDNFRAQFDAMPWRDDPAALRAWQRGRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDW
RAGEAWFWDTLVDADPANNAASWQWVAGCGADAAPYFRIFNPVAQGQKFDPDGAYVRRWVPELAGLDNASIHAPWEASPL
ELDAAGVRLGVDYPAPLVEHAAARARALDALAALPKRR

Sequences:

>Translated_518_residues
MCVARRHHAAQPRQYVSLSAFVIEVPVPAKSSVAPAIVWFRDDLRVTDQPALTRAVESGRPLVCVFVDDTGDGAGRALGG
AARWWLHGSLAGLDAALARHGGRLLLLRGDAQREIERVVHDTGAEAVYWNRRYAQPQRDADAALKASLKARGVTVESSNG
SLLNEPWEVLTGSGGPYQVFTAYWRAARRDRTVAVPLPEPERIAFHPWPKAVRDCALALDVLALRPPVPDWAGGLRDAWP
APDEAGAHARLDAFLTASLAGYADARDLPDRPATSRLSPFLRFGNLSPRQVWHAVQGAANAGGAAVAADADKFLSELGWR
EFSYTLLYHFPALASDNFRAQFDAMPWRDDPAALRAWQRGRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDW
RAGEAWFWDTLVDADPANNAASWQWVAGCGADAAPYFRIFNPVAQGQKFDPDGAYVRRWVPELAGLDNASIHAPWEASPL
ELDAAGVRLGVDYPAPLVEHAAARARALDALAALPKRR
>Mature_518_residues
MCVARRHHAAQPRQYVSLSAFVIEVPVPAKSSVAPAIVWFRDDLRVTDQPALTRAVESGRPLVCVFVDDTGDGAGRALGG
AARWWLHGSLAGLDAALARHGGRLLLLRGDAQREIERVVHDTGAEAVYWNRRYAQPQRDADAALKASLKARGVTVESSNG
SLLNEPWEVLTGSGGPYQVFTAYWRAARRDRTVAVPLPEPERIAFHPWPKAVRDCALALDVLALRPPVPDWAGGLRDAWP
APDEAGAHARLDAFLTASLAGYADARDLPDRPATSRLSPFLRFGNLSPRQVWHAVQGAANAGGAAVAADADKFLSELGWR
EFSYTLLYHFPALASDNFRAQFDAMPWRDDPAALRAWQRGRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDW
RAGEAWFWDTLVDADPANNAASWQWVAGCGADAAPYFRIFNPVAQGQKFDPDGAYVRRWVPELAGLDNASIHAPWEASPL
ELDAAGVRLGVDYPAPLVEHAAARARALDALAALPKRR

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=511, Percent_Identity=28.7671232876712, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4758072, Length=499, Percent_Identity=29.2585170340681, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI188536103, Length=465, Percent_Identity=27.741935483871, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1786926, Length=501, Percent_Identity=37.7245508982036, Blast_Score=274, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6324962, Length=521, Percent_Identity=27.447216890595, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17137248, Length=512, Percent_Identity=30.2734375, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24585455, Length=512, Percent_Identity=30.2734375, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24648152, Length=536, Percent_Identity=26.865671641791, Blast_Score=149, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 56770; Mature: 56770

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVARRHHAAQPRQYVSLSAFVIEVPVPAKSSVAPAIVWFRDDLRVTDQPALTRAVESGR
CCCCCCCCCCCCHHHEEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCC
PLVCVFVDDTGDGAGRALGGAARWWLHGSLAGLDAALARHGGRLLLLRGDAQREIERVVH
CEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
DTGAEAVYWNRRYAQPQRDADAALKASLKARGVTVESSNGSLLNEPWEVLTGSGGPYQVF
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHEECCCCCHHHH
TAYWRAARRDRTVAVPLPEPERIAFHPWPKAVRDCALALDVLALRPPVPDWAGGLRDAWP
HHHHHHHCCCCEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
APDEAGAHARLDAFLTASLAGYADARDLPDRPATSRLSPFLRFGNLSPRQVWHAVQGAAN
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCC
AGGAAVAADADKFLSELGWREFSYTLLYHFPALASDNFRAQFDAMPWRDDPAALRAWQRG
CCCCEEECCHHHHHHHHCCCHHEEEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHCC
RTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDWRAGEAWFWDTLVDADPANNA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCCCC
ASWQWVAGCGADAAPYFRIFNPVAQGQKFDPDGAYVRRWVPELAGLDNASIHAPWEASPL
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCC
ELDAAGVRLGVDYPAPLVEHAAARARALDALAALPKRR
EEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MCVARRHHAAQPRQYVSLSAFVIEVPVPAKSSVAPAIVWFRDDLRVTDQPALTRAVESGR
CCCCCCCCCCCCHHHEEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCC
PLVCVFVDDTGDGAGRALGGAARWWLHGSLAGLDAALARHGGRLLLLRGDAQREIERVVH
CEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
DTGAEAVYWNRRYAQPQRDADAALKASLKARGVTVESSNGSLLNEPWEVLTGSGGPYQVF
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHEECCCCCHHHH
TAYWRAARRDRTVAVPLPEPERIAFHPWPKAVRDCALALDVLALRPPVPDWAGGLRDAWP
HHHHHHHCCCCEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
APDEAGAHARLDAFLTASLAGYADARDLPDRPATSRLSPFLRFGNLSPRQVWHAVQGAAN
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCC
AGGAAVAADADKFLSELGWREFSYTLLYHFPALASDNFRAQFDAMPWRDDPAALRAWQRG
CCCCEEECCHHHHHHHHCCCHHEEEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHCC
RTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDWRAGEAWFWDTLVDADPANNA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCCCC
ASWQWVAGCGADAAPYFRIFNPVAQGQKFDPDGAYVRRWVPELAGLDNASIHAPWEASPL
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCC
ELDAAGVRLGVDYPAPLVEHAAARARALDALAALPKRR
EEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]