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The map label for this gene is lolC [H]

Identifier: 78066889

GI number: 78066889

Start: 2488454

End: 2489707

Strand: Reverse

Name: lolC [H]

Synonym: Bcep18194_A5420

Alternate gene names: 78066889

Gene position: 2489707-2488454 (Counterclockwise)

Preceding gene: 78066895

Following gene: 78066888

Centisome position: 67.4

GC content: 66.03

Gene sequence:

>1254_bases
TTGAAACTTCCGTACGAATGGCAGATCGGCTGGCGCTACACGCGCGCCGGCAAACGCACGACCGGTAACGGCTTCATTTC
CTTCATCGCGCTCGTGTCGATGCTCGGGATCGCGCTCGGCGTCGCGGCGCTGATCGTCGTGCTGTCGGTGATGAACGGCT
TCCAGAAGGAAGTGCGCGACCGCATGCTGTCGGTGCTCGCGCACGTCGAGGTGTTCTCGCCGACGGGGTCGATGCCCGAC
TGGCAACTGACCGCGCAGGAAGCACGCCGCAATCCGTCGGTAATCGGCGCGGCGCCGTACGTCGATGCGCAGGCGTTGCT
TACCCGCCAGGACGCGGTGAGCGGCGTGATGCTGCGCGGCGTCGAACCGACGCTCGAGCCGCAGGTGTCGGACATCGGCA
AGGACATGAAGGCGGGCCAGCTCGGCGCGCTCGTGCCGGGCCAGTTCGGCATCGTGCTCGGCGATGCGCTCGCGGGCAAC
CTCGGCGTGACGGTCGGCGACAAGGTCACGCTGGTCGCGCCGGAAGGGTCGATCACGCCGGCCGGCATGATGCCGCGGCT
GAAGCAGTTCACGGTCGTCGGCGTGTTCGAGTCCGGGCACTATGAATACGACAGCACGCTCGCGATGATCAACATCCGCG
ACGCCGAGGCGCTGTTCCGGATGTCCGCGCCGACCGGCGTGCGGCTGCGGCTGAAGGACATGCAGAAGGCGCCGGACGTG
GCGGTCGAGCTGTCGCATACGCTGTCGGGCAGCCTGTACATCCGCGACTGGACCCAGCAGAACAAGACGTGGTTCTCGGC
CGTGCAGATCGAGAAGCGGATGATGTTCATCATCCTCACGCTGATCATCGCGGTGGCCGCGTTCAACCTCGTGTCGTCGC
TCGTGATGACCGTGACCAACAAGCAGGCCGACATCGCGATCCTGCGCACGCTCGGCGCGCAGCCGGGATCGATCATGAAG
ATCTTCGTCGTGCAGGGCGTGACGATCGGTTTCGTCGGCACGGCGTCGGGCGTCGCGCTCGGCTGCCTGATCGCGTGGAG
CATCCCGTGGCTGATCCCGATGATCGAGCACCTGTTCGGCGTGCAGTTCCTGCCGCCGTCCGTGTACTTCATCAGCGAAC
TGCCGTCGGAACTCGTCGCGAGCGACGTGATCCGGATCGGGCTGATCGCATTCGCGCTGTCGGCGATCGCGACGCTCTAT
CCGAGCTGGCGCGGCGCGAAGGTGAAGCCGGCGGAGGCGCTCCGTTATGAATGA

Upstream 100 bases:

>100_bases
CCGGCGGCCGTTTTTCGACCGTGCCCGGGCCGGTGGCCGCCACCGGGCGGCGGTCCGGCCGCGGGGCGCCTCCCCGCCGT
AACCAGCAGAAAGGATTCGC

Downstream 100 bases:

>100_bases
TCGCGCGACCGCATTCGCGGATTCACGACAACACAACAGACAGGATTCGGCAGGTATGCAGGAATACGTGCTTCAGGCGC
GCGGGGTCACGAAGGCTTTC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLAHVEVFSPTGSMPD
WQLTAQEARRNPSVIGAAPYVDAQALLTRQDAVSGVMLRGVEPTLEPQVSDIGKDMKAGQLGALVPGQFGIVLGDALAGN
LGVTVGDKVTLVAPEGSITPAGMMPRLKQFTVVGVFESGHYEYDSTLAMINIRDAEALFRMSAPTGVRLRLKDMQKAPDV
AVELSHTLSGSLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTNKQADIAILRTLGAQPGSIMK
IFVVQGVTIGFVGTASGVALGCLIAWSIPWLIPMIEHLFGVQFLPPSVYFISELPSELVASDVIRIGLIAFALSAIATLY
PSWRGAKVKPAEALRYE

Sequences:

>Translated_417_residues
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLAHVEVFSPTGSMPD
WQLTAQEARRNPSVIGAAPYVDAQALLTRQDAVSGVMLRGVEPTLEPQVSDIGKDMKAGQLGALVPGQFGIVLGDALAGN
LGVTVGDKVTLVAPEGSITPAGMMPRLKQFTVVGVFESGHYEYDSTLAMINIRDAEALFRMSAPTGVRLRLKDMQKAPDV
AVELSHTLSGSLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTNKQADIAILRTLGAQPGSIMK
IFVVQGVTIGFVGTASGVALGCLIAWSIPWLIPMIEHLFGVQFLPPSVYFISELPSELVASDVIRIGLIAFALSAIATLY
PSWRGAKVKPAEALRYE
>Mature_417_residues
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLAHVEVFSPTGSMPD
WQLTAQEARRNPSVIGAAPYVDAQALLTRQDAVSGVMLRGVEPTLEPQVSDIGKDMKAGQLGALVPGQFGIVLGDALAGN
LGVTVGDKVTLVAPEGSITPAGMMPRLKQFTVVGVFESGHYEYDSTLAMINIRDAEALFRMSAPTGVRLRLKDMQKAPDV
AVELSHTLSGSLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTNKQADIAILRTLGAQPGSIMK
IFVVQGVTIGFVGTASGVALGCLIAWSIPWLIPMIEHLFGVQFLPPSVYFISELPSELVASDVIRIGLIAFALSAIATLY
PSWRGAKVKPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=416, Percent_Identity=33.4134615384615, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1787360, Length=421, Percent_Identity=36.8171021377672, Blast_Score=205, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45112; Mature: 45112

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRD
CCCCCEEEECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLAHVEVFSPTGSMPDWQLTAQEARRNPSVIGAAPYVDAQALLTRQDAVSGVMLRG
HHHHHHHHHHEECCCCCCCCCEEEHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCEEEC
VEPTLEPQVSDIGKDMKAGQLGALVPGQFGIVLGDALAGNLGVTVGDKVTLVAPEGSITP
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEECHHCCCCCEEECCEEEEECCCCCCCC
AGMMPRLKQFTVVGVFESGHYEYDSTLAMINIRDAEALFRMSAPTGVRLRLKDMQKAPDV
CCCCCHHHHEEEEEEEECCCEECCCEEEEEEECCHHHHHHCCCCCCCEEEEHHHCCCCCC
AVELSHTLSGSLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTN
EEEEHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KQADIAILRTLGAQPGSIMKIFVVQGVTIGFVGTASGVALGCLIAWSIPWLIPMIEHLFG
CCHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
VQFLPPSVYFISELPSELVASDVIRIGLIAFALSAIATLYPSWRGAKVKPAEALRYE
CCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRD
CCCCCEEEECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLAHVEVFSPTGSMPDWQLTAQEARRNPSVIGAAPYVDAQALLTRQDAVSGVMLRG
HHHHHHHHHHEECCCCCCCCCEEEHHHHCCCCCEEECCCCCCHHHHHHHHHHHCCCEEEC
VEPTLEPQVSDIGKDMKAGQLGALVPGQFGIVLGDALAGNLGVTVGDKVTLVAPEGSITP
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEECHHCCCCCEEECCEEEEECCCCCCCC
AGMMPRLKQFTVVGVFESGHYEYDSTLAMINIRDAEALFRMSAPTGVRLRLKDMQKAPDV
CCCCCHHHHEEEEEEEECCCEECCCEEEEEEECCHHHHHHCCCCCCCEEEEHHHCCCCCC
AVELSHTLSGSLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTN
EEEEHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KQADIAILRTLGAQPGSIMKIFVVQGVTIGFVGTASGVALGCLIAWSIPWLIPMIEHLFG
CCHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
VQFLPPSVYFISELPSELVASDVIRIGLIAFALSAIATLYPSWRGAKVKPAEALRYE
CCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]