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The map label for this gene is lpxB

Identifier: 78066785

GI number: 78066785

Start: 2367921

End: 2369090

Strand: Reverse

Name: lpxB

Synonym: Bcep18194_A5316

Alternate gene names: 78066785

Gene position: 2369090-2367921 (Counterclockwise)

Preceding gene: 78066786

Following gene: 78066784

Centisome position: 64.13

GC content: 68.8

Gene sequence:

>1170_bases
ATGCCGCTTCCGACCTCTCAGCTCCGGCTCGCGATGGTGGCCGGCGAACCGTCGGGCGACCTGCTCGGCGCGTCGCTGCT
CGGCGGGCTGCGCGAGCGGCTGCCCGAATCGGCCCAGTACTACGGGATCGGCGGGCAGCGGATGATCGCGCAGGGCTTCG
ACTCGCACTGGCAGATGGACAAGCTGACCGTGCGCGGCTATGTCGAGGCGCTGGGCCAGATTCCCGAGATCCTGCGGATT
CGCGGCGAGCTGAAGCGCCAGTTGCTCGCCGAGCGGCCGGACGCGTTCATCGGCGTCGACGCGCCCGACTTCAACTTCAA
CGTCGAACAGGCCGCGCGCGACGCGGGCATCCCGTCGATCCACTTCGTGTGCCCGTCGATCTGGGCATGGCGCGGCGGCC
GGATCAAGAAGATCGCGAAGTCCGTCGACCACATGCTGTGCCTGTTCCCGTTCGAGCCGGCGATTCTCGACAAGGCAGGC
GTTGCCTCGACCTACGTCGGCCACCCGCTCGCCGACGAGATTCCGCTCGAACCCGACACGCACGGTGCGCGCATCGCACT
CGGACTGCCGGCCGACGGCCCGGTGATCGCGGTGCTGCCGGGCAGCCGGCGCTCGGAAATCGCGCTGATCGGCCCGACGT
TCTTCGCGGCGATGGCGCTGATGCAGCAACGCGAGCCCGGCGTGCGGTTCGTGATGCCGGCGGCGACGCCCGCGCTGCGC
GCGCTGCTGCAGCCGCTCGTCGACGCGCATCCGAAGCTCGCGCTGACGATCACCGACGGCCGCTCGCAGGTCGCGATGAC
GGCTGCCGACGCGATCCTCGTGAAGAGCGGCACGGTCACGCTGGAAGCCGCGCTGCTGAAGAAGCCGATGGTGATCTCGT
ACAAGGTGCCCTGGCTGACCGGGCAGATCATGCGCCGGCAGGGTTACCTGCCGTACGTCGGCTTGCCGAATATCCTGGCG
GGGCGTTTCGTCGTGCCCGAGCTGCTGCAGCATTTCGCGACGCCCGAGGCGCTCGCCGATGCGACGCTCACGCAGTTGCG
CGACGACGCGAACCGCCGCACGCTGACCGAAATATTTACCGAAATGCATCTTTCGCTGCGGCAGAACACGGCCGCGAAGG
CGGCCGAAGCCGTCGTGCGCGTGCTCGAACAACGCAAGGGGCGCGCATGA

Upstream 100 bases:

>100_bases
GTTGCGCGAGCTGGCCGCCGCGGGCGGCGAGGGCGACGCAGCCGTGAAGACGCTCGTCGAGTTCATCGACGCGTCGCAAC
GCGGCATCATCCGCTAAGCG

Downstream 100 bases:

>100_bases
CCGCAGTACGTGCACCACGCCGTCGCGCGTCGAGCGACGAGCAGGGCGGGTTCGATTTCAGCCGTCCCGACGAGATCGTC
TGCGGCGTCGACGAAGCGGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPLPTSQLRLAMVAGEPSGDLLGASLLGGLRERLPESAQYYGIGGQRMIAQGFDSHWQMDKLTVRGYVEALGQIPEILRI
RGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAG
VASTYVGHPLADEIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGVRFVMPAATPALR
ALLQPLVDAHPKLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEIFTEMHLSLRQNTAAKAAEAVVRVLEQRKGRA

Sequences:

>Translated_389_residues
MPLPTSQLRLAMVAGEPSGDLLGASLLGGLRERLPESAQYYGIGGQRMIAQGFDSHWQMDKLTVRGYVEALGQIPEILRI
RGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAG
VASTYVGHPLADEIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGVRFVMPAATPALR
ALLQPLVDAHPKLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEIFTEMHLSLRQNTAAKAAEAVVRVLEQRKGRA
>Mature_388_residues
PLPTSQLRLAMVAGEPSGDLLGASLLGGLRERLPESAQYYGIGGQRMIAQGFDSHWQMDKLTVRGYVEALGQIPEILRIR
GELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGV
ASTYVGHPLADEIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGVRFVMPAATPALRA
LLQPLVDAHPKLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAG
RFVVPELLQHFATPEALADATLTQLRDDANRRTLTEIFTEMHLSLRQNTAAKAAEAVVRVLEQRKGRA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=375, Percent_Identity=39.7333333333333, Blast_Score=285, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42302; Mature: 42171

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPTSQLRLAMVAGEPSGDLLGASLLGGLRERLPESAQYYGIGGQRMIAQGFDSHWQMD
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCCCCCCHH
KLTVRGYVEALGQIPEILRIRGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCCEE
HFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGVASTYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHEEEEECCCHHHHCCCCCCHHHCCCCCCCCCCCCCCC
HGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGVRFVMPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALLQPLVDAHPKLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCCEEEEEECCCCEEEHHHHCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EMHLSLRQNTAAKAAEAVVRVLEQRKGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLPTSQLRLAMVAGEPSGDLLGASLLGGLRERLPESAQYYGIGGQRMIAQGFDSHWQMD
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHCCCCCCCHH
KLTVRGYVEALGQIPEILRIRGELKRQLLAERPDAFIGVDAPDFNFNVEQAARDAGIPSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCCEE
HFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGVASTYVGHPLADEIPLEPDT
EEECCHHHHCCCCHHHHHHHHHHHEEEEECCCHHHHCCCCCCHHHCCCCCCCCCCCCCCC
HGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGVRFVMPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALLQPLVDAHPKLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCCEEEEEECCCCEEEHHHHCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
EMHLSLRQNTAAKAAEAVVRVLEQRKGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA