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The map label for this gene is hdaH [H]

Identifier: 78066701

GI number: 78066701

Start: 2288854

End: 2289963

Strand: Direct

Name: hdaH [H]

Synonym: Bcep18194_A5232

Alternate gene names: 78066701

Gene position: 2288854-2289963 (Clockwise)

Preceding gene: 78066700

Following gene: 78066702

Centisome position: 61.96

GC content: 67.66

Gene sequence:

>1110_bases
ATGAATCGCACTGCCTTCTTCACCGACGAACGCACTTTCTGGCATACCGGCGGCACGCACGCGCTGTTCTTCCCGGTCGG
CGGCTGGGTCCAGCCGCCGTCGAGCGCGGGCTACGCGGAATCGCCCGATTCGAAACGCCGTTTCCTGTCGCTCGTGCAGG
CCTCGGGCCTGGCCGCGCAACTCGACCTGCGCGGCGCCGAGCCGGCCTCGACCACCGACCTGTTGCGCATTCACCCTGCG
CACTATCTCGACGCGTTCCGCGCACTCAGCGATGCGAACGGCGGCGACCTCGGCGATCTCGCGCCGTTCGGCAAGGGTAG
CTACGAGATCGCCGCGCTGTCCGCCGGCCTCGCGATCACGGCCGTCGATACGGTGCTCGGCGAACGTGCGGCGAACGCTT
TCTCACTGTCGCGGCCACCCGGCCATCACTGCCTGCGCGACCGCCCGATGGGCTTCTGCCTGCTGGCGAACATTCCGATC
GCGATCGAAGCCGCGCGCGCGAAACACGGCATCGAGCGCATCGCGGTGATCGATTGGGACGTGCATCACGGCAACGGCAC
GCAGTCGATCTACTACGACGATCCGGACACGCTGACGATCTCGCTGCATCAGGATCGTTGCTTCCCGCCCGGCTACAGCG
GCGCGGACGACCGCGGCGAAGGCGCTGGCGCGGGCGCGAACCTGAACGTGCCGCTGCTCGCGGGCAGCGGCGACGATGCA
TATCGCTACGCATTCGAGCGGATCGTGCTGCCGGCGCTGGAGCGTTTCCGGCCCGAGCTCATCGTCATCGCGAGCGGCCT
CGACGCGAGCGCGGTCGATCCGCTCGCGCGCATGCAACTGCATACCGACAGCTACCGGTTCATGACGCGTGCGGTGAAGG
AGGCCGCGCAACGCCATTGCGGTGGGCGCCTCGTGATCGTTCACGAAGGCGGCTATTCGGAAGCGTATGTGCCATTCTGC
GGGCTCGCGATCGTCGAGGAACTGGCGGGTGTTCGCACCGACGTCGCCGATCCGATGCTCGACCTCGCGATCGCGCAGCA
GCCGGGCGAGCGGTTCGTCGCGTTCCAGCGCGAACTGCTCGACGAACTGGCGGCGTCGTTCGGGTTATAG

Upstream 100 bases:

>100_bases
GCGACGGCCGTCGCGATCGTGTCGTTCGCCGCGCTGCGCCACATCGATCGCCGCACGCGCCCCTCCGTTTCCACCCAACC
GTGACAGGTCACGCACATCC

Downstream 100 bases:

>100_bases
CGCGCGCCGGGAGACGCGACGAAGGGTCGGCCTGAGCCGGCCCTCTTGCGCGATCGGAGCGAATGGGGTTTCCTGTGCTT
TTACCCCCGTTCCGGCGCAA

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQLDLRGAEPASTTDLLRIHPA
HYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAITAVDTVLGERAANAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIERIAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGAGANLNVPLLAGSGDDA
YRYAFERIVLPALERFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGVRTDVADPMLDLAIAQQPGERFVAFQRELLDELAASFGL

Sequences:

>Translated_369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQLDLRGAEPASTTDLLRIHPA
HYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAITAVDTVLGERAANAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIERIAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGAGANLNVPLLAGSGDDA
YRYAFERIVLPALERFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGVRTDVADPMLDLAIAQQPGERFVAFQRELLDELAASFGL
>Mature_369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQLDLRGAEPASTTDLLRIHPA
HYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAITAVDTVLGERAANAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIERIAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGAGANLNVPLLAGSGDDA
YRYAFERIVLPALERFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGVRTDVADPMLDLAIAQQPGERFVAFQRELLDELAASFGL

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=291, Percent_Identity=33.6769759450172, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI20070354, Length=284, Percent_Identity=34.5070422535211, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI153085395, Length=259, Percent_Identity=32.4324324324324, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI148539870, Length=250, Percent_Identity=34, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI169234807, Length=250, Percent_Identity=34, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI17158039, Length=265, Percent_Identity=30.188679245283, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI30795202, Length=259, Percent_Identity=30.5019305019305, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI30795204, Length=259, Percent_Identity=30.5019305019305, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI62750347, Length=238, Percent_Identity=31.9327731092437, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI62750349, Length=238, Percent_Identity=31.9327731092437, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI226529806, Length=285, Percent_Identity=32.280701754386, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI8923769, Length=251, Percent_Identity=28.2868525896414, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13128860, Length=254, Percent_Identity=24.8031496062992, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI293336691, Length=267, Percent_Identity=24.3445692883895, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI13128862, Length=256, Percent_Identity=27.34375, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=29.5964125560538, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073088, Length=140, Percent_Identity=32.1428571428571, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=31.0679611650485, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=31.0679611650485, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=31.0679611650485, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI193209491, Length=243, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508561, Length=313, Percent_Identity=28.1150159744409, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25154020, Length=286, Percent_Identity=26.5734265734266, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17561978, Length=297, Percent_Identity=28.2828282828283, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI25154022, Length=286, Percent_Identity=25.8741258741259, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534739, Length=244, Percent_Identity=29.0983606557377, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17537347, Length=255, Percent_Identity=27.843137254902, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324307, Length=365, Percent_Identity=29.8630136986301, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323999, Length=288, Percent_Identity=27.7777777777778, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321244, Length=274, Percent_Identity=29.5620437956204, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325141, Length=312, Percent_Identity=28.8461538461538, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=199, Percent_Identity=24.6231155778894, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281360899, Length=334, Percent_Identity=32.9341317365269, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24642146, Length=334, Percent_Identity=32.9341317365269, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24642142, Length=334, Percent_Identity=32.9341317365269, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24642144, Length=334, Percent_Identity=32.9341317365269, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24641720, Length=253, Percent_Identity=35.1778656126482, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281360799, Length=253, Percent_Identity=35.1778656126482, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281360801, Length=253, Percent_Identity=35.1778656126482, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24657891, Length=294, Percent_Identity=26.530612244898, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644244, Length=299, Percent_Identity=26.4214046822742, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39701; Mature: 39701

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQ
CCCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDLRGAEPASTTDLLRIHPAHYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIT
EECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCEEEE
AVDTVLGERAANAFSLSRPPGHHCLRDRPMGFCLLANIPIAIEAARAKHGIERIAVIDWD
HHHHHHHHHHCCCEECCCCCCCHHHHCCCCCEEEEECCCEEEEHHHHHCCCEEEEEEEEE
VHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGAGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALERFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCHHHHHEECCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGVRTDVADPMLDLAIAQQPGERFVAFQRELL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DELAASFGL
HHHHHHHCC
>Mature Secondary Structure
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQ
CCCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDLRGAEPASTTDLLRIHPAHYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIT
EECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCEEEE
AVDTVLGERAANAFSLSRPPGHHCLRDRPMGFCLLANIPIAIEAARAKHGIERIAVIDWD
HHHHHHHHHHCCCEECCCCCCCHHHHCCCCCEEEEECCCEEEEHHHHHCCCEEEEEEEEE
VHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGAGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALERFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCHHHHHEECCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGVRTDVADPMLDLAIAQQPGERFVAFQRELL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DELAASFGL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA