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The map label for this gene is glxR [H]

Identifier: 78066649

GI number: 78066649

Start: 2226494

End: 2227387

Strand: Direct

Name: glxR [H]

Synonym: Bcep18194_A5180

Alternate gene names: 78066649

Gene position: 2226494-2227387 (Clockwise)

Preceding gene: 78066648

Following gene: 78066650

Centisome position: 60.27

GC content: 66.78

Gene sequence:

>894_bases
ATGGCAACCATCGGTTTCATCGGCCTCGGCATCATGGGCGCGCACATGGCGCGCAACCTGCTCAAGGGCGACCACCAGCT
CGTCGTGAACGGCGCGTTCCCGATCCCCGACGACCTGCGCACGAGCGCAAAGGTCGTCGCGAACTCGACCGAAGTCGCGC
AGAACGCGGACATCATCGTCGTGATGGTGCCGGATACGCCGGACGTGCGTAACGTGCTGTTCGCCGACGACGGCGTCGCG
AAGGGCCTGACGGCCGGCAAGCTCGTGATCGACATGAGCTCGATCTCGCCGCTCGACACGCAGGAATTCGCGAAACAGAT
CAACGCCCTCGGCTGCGACTACCTCGACGCACCGGTGTCCGGCGGCGAAGTCGGCGCACGCGAAGCGTCGCTGACGATCA
TGGTCGGCGGCCCGGAAGCGGCATTCGAGCGCGCCAAGCCGCTGTTCGAGAAGATGGGCAAGAACATCACGCTCGTCGGC
GACAACGGCGCGGGCCAGACCTGCAAGGTCGCGAACCAGATCATCGTCGCGCTGAACATCGAAGCGGTCGGCGAAGCGCT
GCTGTTCGCCGCGCGTTCGGGCGCCGATCCGGAGCGTGTGCGCCAGGCGCTGATGGGCGGCTTCGCCGCATCGCGCATCC
TGGAAGTGCACGGCGCGCGGATGACGAAGCGCACGTTCGATCCGGGCTTCCGCATCGAGCTGCACCAGAAGGACCTGAAC
CTCGCGCTCGACGGCGCACGCAAGCTCGGCCTCGCACTGCCGCACACGGCCAGCGCACAGCAGCTGTTCAGCGTGTGTGC
ATCGCACGGCGGCAAGGCATGGGACCACTCGGCACTCGTGCGCGCGCTCGAGATCATGTCGAACTTCGAGATCGGCCAGA
CGCCGGCCGCGTAA

Upstream 100 bases:

>100_bases
TCGGCTGGCTGCAAAGCGTCGCCGGCTGCGCACCGGGCTCGGCGCGTCGCGCCGCCTGAGTCACGCCCTTCCCGTTTTCA
GCCCTATAGGAGACATTTAC

Downstream 100 bases:

>100_bases
CACGGCTGCAACGATGCGCGTTTCCGCTGCGATGGCGGACGCGCACGACAGACACACGTGACCGGCACGGCCGGTCGCAT
CGATGCGCGATGCACCACGC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRTSAKVVANSTEVAQNADIIVVMVPDTPDVRNVLFADDGVA
KGLTAGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVSGGEVGAREASLTIMVGGPEAAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA

Sequences:

>Translated_297_residues
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRTSAKVVANSTEVAQNADIIVVMVPDTPDVRNVLFADDGVA
KGLTAGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVSGGEVGAREASLTIMVGGPEAAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
>Mature_296_residues
ATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRTSAKVVANSTEVAQNADIIVVMVPDTPDVRNVLFADDGVAK
GLTAGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVSGGEVGAREASLTIMVGGPEAAFERAKPLFEKMGKNITLVGD
NGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLNL
ALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=31.1475409836066, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=27.3049645390071, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=65.0519031141868, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI145693186, Length=290, Percent_Identity=41.3793103448276, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=34.1379310344828, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789092, Length=289, Percent_Identity=29.757785467128, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=287, Percent_Identity=32.0557491289199, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=36.996336996337, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=36.996336996337, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=29.4117647058824, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31220; Mature: 31089

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRTSAKVVANSTEVAQNADIIV
CCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCEEE
VMVPDTPDVRNVLFADDGVAKGLTAGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVS
EECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGAREASLTIMVGGPEAAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCC
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPIPDDLRTSAKVVANSTEVAQNADIIV
CEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHCCCCEEE
VMVPDTPDVRNVLFADDGVAKGLTAGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVS
EECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGAREASLTIMVGGPEAAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCC
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]