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The map label for this gene is hyi [H]

Identifier: 78066648

GI number: 78066648

Start: 2225643

End: 2226452

Strand: Direct

Name: hyi [H]

Synonym: Bcep18194_A5179

Alternate gene names: 78066648

Gene position: 2225643-2226452 (Clockwise)

Preceding gene: 78066647

Following gene: 78066649

Centisome position: 60.25

GC content: 66.91

Gene sequence:

>810_bases
ATGCCGAAGTTTGCTGCAAACCTGACCATGCTGTTCAACGAAGTGCCGTTCCTCGACCGCTTCAAGGCGGCCGCCGACGC
GGGCTTCGACGCCGTCGAGTTCCTGTTCCCGTATCCGTACGCGAAAGAGGAACTCGCCGAGCGGCTCGAGACGCATCGCC
TGCGCCTCGTGCTGCACAACCTGCCCGCCGGCAACTGGGACCAGGGCGAGCGCGGCATCGCGTGCCTGCCCGATCGCGTC
GGCGAATTCCAGGAAGGTGTCGGCCGTGCGATCGAGTACGCGAAGGCGCTGAAGGTGCCGCAGCTGAACTGCCTCGTCGG
CATCCCGTCGGCGAGCACGGCGCGCGACAAGACCTTCGTCACGATCGTCGACAACCTGCGCTTTGCCGCCGACGCGCTCA
AGCGCGAAGGCATCCGCCTGCTCGTCGAGCCGTGCAACTGCTTCGACATCCCGGGCTTCGCGCTGAACCGCTCGTCGGAA
GGGCTCGACGTGATCCGCGCGGTCGGCTCGGACAACCTGTTCCTGCAGTACGACATCTATCACATGCAGCGCATGGAAGG
CGAACTGGCCGCGACGATCGAACGCAACCTCGCATCGATCGGCCACGTCCAGCTCGCGGACAACCCGGGCCGTAACGAGC
CGGGCACGGGCGAGATCAACTACGCGTTCCTGTTCGCGCTGCTCGACCGGCTCGGCTATGCCGGTTACGTCGGCTGCGAG
TACAAGCCCCGCACCACCACGACGGAAGGCCTCGGCTGGCTGCAAAGCGTCGCCGGCTGCGCACCGGGCTCGGCGCGTCG
CGCCGCCTGA

Upstream 100 bases:

>100_bases
GAGGATCTCGCCGAAAAGGCCGAGCACGCACCGACCGCAATCTCGATGCTCGACTGAACCGCACGACATTTTTGACTGAC
CGACCGAAGAGGCTTAGCTC

Downstream 100 bases:

>100_bases
GTCACGCCCTTCCCGTTTTCAGCCCTATAGGAGACATTTACATGGCAACCATCGGTTTCATCGGCCTCGGCATCATGGGC
GCGCACATGGCGCGCAACCT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPKFAANLTMLFNEVPFLDRFKAAADAGFDAVEFLFPYPYAKEELAERLETHRLRLVLHNLPAGNWDQGERGIACLPDRV
GEFQEGVGRAIEYAKALKVPQLNCLVGIPSASTARDKTFVTIVDNLRFAADALKREGIRLLVEPCNCFDIPGFALNRSSE
GLDVIRAVGSDNLFLQYDIYHMQRMEGELAATIERNLASIGHVQLADNPGRNEPGTGEINYAFLFALLDRLGYAGYVGCE
YKPRTTTTEGLGWLQSVAGCAPGSARRAA

Sequences:

>Translated_269_residues
MPKFAANLTMLFNEVPFLDRFKAAADAGFDAVEFLFPYPYAKEELAERLETHRLRLVLHNLPAGNWDQGERGIACLPDRV
GEFQEGVGRAIEYAKALKVPQLNCLVGIPSASTARDKTFVTIVDNLRFAADALKREGIRLLVEPCNCFDIPGFALNRSSE
GLDVIRAVGSDNLFLQYDIYHMQRMEGELAATIERNLASIGHVQLADNPGRNEPGTGEINYAFLFALLDRLGYAGYVGCE
YKPRTTTTEGLGWLQSVAGCAPGSARRAA
>Mature_268_residues
PKFAANLTMLFNEVPFLDRFKAAADAGFDAVEFLFPYPYAKEELAERLETHRLRLVLHNLPAGNWDQGERGIACLPDRVG
EFQEGVGRAIEYAKALKVPQLNCLVGIPSASTARDKTFVTIVDNLRFAADALKREGIRLLVEPCNCFDIPGFALNRSSEG
LDVIRAVGSDNLFLQYDIYHMQRMEGELAATIERNLASIGHVQLADNPGRNEPGTGEINYAFLFALLDRLGYAGYVGCEY
KPRTTTTEGLGWLQSVAGCAPGSARRAA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=261, Percent_Identity=41.3793103448276, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=39.5061728395062, Blast_Score=160, Evalue=9e-40,
Organism=Escherichia coli, GI1786718, Length=254, Percent_Identity=55.1181102362205, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1789095, Length=256, Percent_Identity=42.96875, Blast_Score=226, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17552022, Length=254, Percent_Identity=38.1889763779528, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17530883, Length=260, Percent_Identity=34.6153846153846, Blast_Score=157, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29605; Mature: 29474

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFAANLTMLFNEVPFLDRFKAAADAGFDAVEFLFPYPYAKEELAERLETHRLRLVLHN
CCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LPAGNWDQGERGIACLPDRVGEFQEGVGRAIEYAKALKVPQLNCLVGIPSASTARDKTFV
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEE
TIVDNLRFAADALKREGIRLLVEPCNCFDIPGFALNRSSEGLDVIRAVGSDNLFLQYDIY
EEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCHHHHHHCCCCCEEEEEHHH
HMQRMEGELAATIERNLASIGHVQLADNPGRNEPGTGEINYAFLFALLDRLGYAGYVGCE
HHHHHCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCC
YKPRTTTTEGLGWLQSVAGCAPGSARRAA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PKFAANLTMLFNEVPFLDRFKAAADAGFDAVEFLFPYPYAKEELAERLETHRLRLVLHN
CCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LPAGNWDQGERGIACLPDRVGEFQEGVGRAIEYAKALKVPQLNCLVGIPSASTARDKTFV
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEE
TIVDNLRFAADALKREGIRLLVEPCNCFDIPGFALNRSSEGLDVIRAVGSDNLFLQYDIY
EEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECCCCCCHHHHHHCCCCCEEEEEHHH
HMQRMEGELAATIERNLASIGHVQLADNPGRNEPGTGEINYAFLFALLDRLGYAGYVGCE
HHHHHCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCC
YKPRTTTTEGLGWLQSVAGCAPGSARRAA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]