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The map label for this gene is norM [H]

Identifier: 78066605

GI number: 78066605

Start: 2180876

End: 2182237

Strand: Direct

Name: norM [H]

Synonym: Bcep18194_A5136

Alternate gene names: 78066605

Gene position: 2180876-2182237 (Clockwise)

Preceding gene: 78066604

Following gene: 78066612

Centisome position: 59.04

GC content: 69.6

Gene sequence:

>1362_bases
ATGTTCGGCGACATCCGCCGGATTGTCGGTCTCGCGTGGCCGGTGCTCGTCGGCCAGCTCGCGATCATCGCGTTCGGCGT
AATCGACACCGCGATGGTCGGGCGCTACTCGGCCGTCGACCTGGCCGCGCTCGGCCTCGGCTCGTCGATCTACATATCGA
TCTATATCGGCCTGACGGGCATCCTGTCCGCGCTGCAGCCGATCACCGGGCAGCTGTACGGCGCGCGGCGCTATGCCGAG
ATCGGCGAGGAAGTGCGCCAGGCGCTGTGGCTCGCGTCGCTGCTCGCGGTGCCCGGCTTCCTCCTGCTGCATTTTCCCGA
GCCGCTGCTGCGCGTCGCGCACACGCCCGCCGCGCTGCACGACCGCACCGTCGACTACCTGCGCATCCTGTCGTACGGGC
TGCCCGCCAGCCTCGTCTTCCGCATCTACAACGCGCTGACCAACGCCGCCGGCAAGCCGCGCCTCGCGATGATCCTGCAG
ATCGGCGCGCTGCTGCTCAAATTTCCGCTCAACGTGTGGTTCATCTTCGGCGGGTTCGGCGTGCCGGCCCTCGGCGGCCC
CGGCTGCGGGCTCGCCAGCGCGCTGATCAACTGGGCACTCGCGGTGATCGGCTACACGCTGCTCGCGAAGCTCGACGTGT
TCGCGCCGCTCGCGATCTTCTCGCGCTTCTGCTGGCCGGTCTGGGAACGCCAGAAGGCGATCCTGAAACTCGGCGTGCCG
ATGGGCCTGTCGTACCTGATCGAGGTCACGTCGTACACGTGCATGGCGCTGTTCATCGCGCAGTTCGGCACGACGACGCT
CGCCGGCCACCAGATCGCCGGCAACATCGGCGCGGTGCTGTACATGACGCCACTGTCGATCGGCGTGGCGGCGTCGACGC
TGGTCGCACGCACGCTTGGCGCCGGACGGCCCGAGGAAGCCCGGCTGCTCGGCCGGCACAGCGTGATCTTCGCGTGCGGC
ATCGCCGCGACCTACGGCCTGCTCGTGTTCGTGCTGCGCCCGCTGATCATCGGCGGCTATACGCCGAACCCGGCCGTCGC
CGCGGCCGCGATGCCGCTCGTCGCGATCGTCGCGTGCTACCACGTCTTCGATGCGCTGCAAGTCACGTCGGCGTTCGTGC
TGCGCGCCTACAAGGTCGCGGTCGTGCCGACCGTGATCTATGCGGTCGCGCTGTGGGGCGTCGGGCTCAGCGGCGGCTAC
GCGCTCGGTTTCGACGTGGGCGGCATCGCGCCCGCGTGGCTGACCGGCGCGCGCGGCTTCTGGTTCGCGAACACGATCAG
CCTGATGCTCGCGGGCGCCGGGCTCGTGCTGTACCTGCGCCGCGTCAGCCGTGCGCATGCCGCCGTGTCCACGTCCGCCT
GA

Upstream 100 bases:

>100_bases
CCGCCGACCGCGACGAGCGCTTCCGCCTGTACGAGCGCATCGAACGGCCGAAGACGCCCGTCAAGCGACGTCCGCCGCGC
CGTCAGCCGGCCGATTGACG

Downstream 100 bases:

>100_bases
CGCGTTGCCCGCTACTTCTCCTCAAGCACGTCGGCCGCGTGATACGACGACCGCACGAGCGGGCCGGCGACGACTTCCCT
GAAACCGAGCAATAGCGCTT

Product: multi anti extrusion protein MatE

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYISIYIGLTGILSALQPITGQLYGARRYAE
IGEEVRQALWLASLLAVPGFLLLHFPEPLLRVAHTPAALHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGVPALGGPGCGLASALINWALAVIGYTLLAKLDVFAPLAIFSRFCWPVWERQKAILKLGVP
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARTLGAGRPEEARLLGRHSVIFACG
IAATYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVACYHVFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGY
ALGFDVGGIAPAWLTGARGFWFANTISLMLAGAGLVLYLRRVSRAHAAVSTSA

Sequences:

>Translated_453_residues
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYISIYIGLTGILSALQPITGQLYGARRYAE
IGEEVRQALWLASLLAVPGFLLLHFPEPLLRVAHTPAALHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGVPALGGPGCGLASALINWALAVIGYTLLAKLDVFAPLAIFSRFCWPVWERQKAILKLGVP
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARTLGAGRPEEARLLGRHSVIFACG
IAATYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVACYHVFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGY
ALGFDVGGIAPAWLTGARGFWFANTISLMLAGAGLVLYLRRVSRAHAAVSTSA
>Mature_453_residues
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYISIYIGLTGILSALQPITGQLYGARRYAE
IGEEVRQALWLASLLAVPGFLLLHFPEPLLRVAHTPAALHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGVPALGGPGCGLASALINWALAVIGYTLLAKLDVFAPLAIFSRFCWPVWERQKAILKLGVP
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARTLGAGRPEEARLLGRHSVIFACG
IAATYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVACYHVFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGY
ALGFDVGGIAPAWLTGARGFWFANTISLMLAGAGLVLYLRRVSRAHAAVSTSA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=428, Percent_Identity=23.1308411214953, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI48994890, Length=447, Percent_Identity=31.7673378076063, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI226510954, Length=425, Percent_Identity=23.2941176470588, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320545, Length=410, Percent_Identity=25.609756097561, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321821, Length=353, Percent_Identity=22.0963172804533, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47891; Mature: 47891

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYISIYIGLTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEHHHHHH
ILSALQPITGQLYGARRYAEIGEEVRQALWLASLLAVPGFLLLHFPEPLLRVAHTPAALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHH
DRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKFPLNVWFIFGGFG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
VPALGGPGCGLASALINWALAVIGYTLLAKLDVFAPLAIFSRFCWPVWERQKAILKLGVP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARTLG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCEEEEECHHHHHHHHHHHHHHHHC
AGRPEEARLLGRHSVIFACGIAATYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVACY
CCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HVFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGYALGFDVGGIAPAWLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHCCCCH
WFANTISLMLAGAGLVLYLRRVSRAHAAVSTSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFGDIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYISIYIGLTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEHHHHHH
ILSALQPITGQLYGARRYAEIGEEVRQALWLASLLAVPGFLLLHFPEPLLRVAHTPAALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHH
DRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKFPLNVWFIFGGFG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
VPALGGPGCGLASALINWALAVIGYTLLAKLDVFAPLAIFSRFCWPVWERQKAILKLGVP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
MGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVAASTLVARTLG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCEEEEECHHHHHHHHHHHHHHHHC
AGRPEEARLLGRHSVIFACGIAATYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVACY
CCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HVFDALQVTSAFVLRAYKVAVVPTVIYAVALWGVGLSGGYALGFDVGGIAPAWLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHCCCCH
WFANTISLMLAGAGLVLYLRRVSRAHAAVSTSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA