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The map label for this gene is emrY [H]

Identifier: 78066601

GI number: 78066601

Start: 2176050

End: 2177606

Strand: Direct

Name: emrY [H]

Synonym: Bcep18194_A5132

Alternate gene names: 78066601

Gene position: 2176050-2177606 (Clockwise)

Preceding gene: 78066600

Following gene: 78066602

Centisome position: 58.91

GC content: 65.64

Gene sequence:

>1557_bases
ATGAGTGCGATGCCCGGTCGCTCGCCGCTGTGGAGCCGCGCGAACCTGCGCGCGGACCTGTTCCCGTGGGCGCTCGCGCT
CGTCACCGGCATCGACTATTTCGACAACGCGGTCTTCTCGTTCTTCGCGAGCTACATCGCGGGCGGCATCAACGCATCGC
CCGACGAACTCGTGTGGTCGTCGAGCGCCTACGCGGTCACGGCCGTGCTCGGCATCCTGCAGCAGCAATGGTGGGTCGAC
CGGCTCGGCCATCGCCGCTACGTCGCCGGCTGCATGCTGATGTTCTCGTTCGGCGCGATCGCAGCCGCGCTCGCCGACAC
GTCGCTCGAACTCGCGTTCGCGCGCGGTTTCCAGGGGTATTTCATCGGCCCGATGATGGGCGCGTGCCGGATCCTGATCC
AGGTCAGTTTCAAGCCGCAGGAACGGCCGCCCGCGACGCGCGCGTTCCTGATCATGATCCTGCTCGGCAGCGCGCTCGCG
CCGATCGTCGGCGGCCTGCTCGTCGCACATTCAACGTGGCGCGCGCTGTTTGCGTGCTCGGCGCCGGCCGGCATCGCATT
CGCGATCCTCGCGCTGCTCACGCTGCCCGATTCGGGCCGGACGCCCGACGACGAACGCGGCTCCGGGCACTTCTGGCCGT
ATGTCGTGTTCGCGCTCGCGCAAGGCGCATTGCAGATCGTGCTGCAACAAGTGCATTACCAGCTCTACAGCGGCTCGCCG
ATGCTGATCCTGCTGACGATCGCGGGGGTCGGCGCGCTGGCGTGGTTCGCGTATCACCAGTGGAACCATCCGACGCCGCT
CGTGCGCCTGCACGCGTTCCGAGAACGGACTTTCCAGGTCGGGCTGCTGCTGTACATGTTCTATTACTACGAGTCGACCG
GCTTCAGTTACCTGACGTCGCGGTTTCTCGAAGGCGGGCTCGGTTACCCGGTCGAGAACGCCGGGCGGCTGGTGGGCACG
ATGTCGCTGATTTCAGCCACCGCGCTGTTCGCGTACCTGCGTTACGCGAAATTCGTCACGCACAAGAAGTGGTTCGTCGT
GCCGGGGTTCGCGATCGCCATCACGGCCGCGCTGTGGATGACGCGGATGACGCCGCAGGTCGGCGAAGCTGCGCTGATCG
TCCCGCTGCTGCTGCGCGGGCTACTGCTGCTCTTCATCGTGCTGCCGGTGGCCAACCTGACGTTCCGGATCTTCGCGATC
GACGAATACACGCATGGCTACCGGTTGAAGAACATTGTGCGGCAACTGACGATCTCGTTCGCGACGTCGTCGGTGATCAT
CGTCGAACAGCACCGCGTGGCCCTGCACCAGACGCGGCTTGTCGAGCGCGCGAACGTGTTCGACCCGGTGTTCCAGCAGA
CCGTCGACACACTGACGCGCAGCTATGCCGCCGCCGGCCACGCGCTGAACGAGGCGCACGGCCTCGCGATCGCATCGATC
GCGCGGATGGTCGCGCAACAGGCGTCGTTCCTCGCATCGCTCGACGGCTTTTACTTCCTGGCGGGTGTGGCGCTGGTCGG
CGGCCTCTTTGCGGCATGGCAAAAAGAGATCGATTGA

Upstream 100 bases:

>100_bases
TCGACTACGTCGATCGGCGTCTTGCCGGCGAAAACGCCGATGCGCTGATCGCGCAGCGGCAGGCGGAAGCCGGCACGCGG
CGCTCGCGCAAGGCGCGCGA

Downstream 100 bases:

>100_bases
GTTAAAAGACAGGCTTTGGATTTCCGCGAGCCGCCTTCATGCTCTCGAAACTGACCCGCTGGTTCGACGACCGCCGCCGC
GACCGCGCGCTGCGCAGCCA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSAMPGRSPLWSRANLRADLFPWALALVTGIDYFDNAVFSFFASYIAGGINASPDELVWSSSAYAVTAVLGILQQQWWVD
RLGHRRYVAGCMLMFSFGAIAAALADTSLELAFARGFQGYFIGPMMGACRILIQVSFKPQERPPATRAFLIMILLGSALA
PIVGGLLVAHSTWRALFACSAPAGIAFAILALLTLPDSGRTPDDERGSGHFWPYVVFALAQGALQIVLQQVHYQLYSGSP
MLILLTIAGVGALAWFAYHQWNHPTPLVRLHAFRERTFQVGLLLYMFYYYESTGFSYLTSRFLEGGLGYPVENAGRLVGT
MSLISATALFAYLRYAKFVTHKKWFVVPGFAIAITAALWMTRMTPQVGEAALIVPLLLRGLLLLFIVLPVANLTFRIFAI
DEYTHGYRLKNIVRQLTISFATSSVIIVEQHRVALHQTRLVERANVFDPVFQQTVDTLTRSYAAAGHALNEAHGLAIASI
ARMVAQQASFLASLDGFYFLAGVALVGGLFAAWQKEID

Sequences:

>Translated_518_residues
MSAMPGRSPLWSRANLRADLFPWALALVTGIDYFDNAVFSFFASYIAGGINASPDELVWSSSAYAVTAVLGILQQQWWVD
RLGHRRYVAGCMLMFSFGAIAAALADTSLELAFARGFQGYFIGPMMGACRILIQVSFKPQERPPATRAFLIMILLGSALA
PIVGGLLVAHSTWRALFACSAPAGIAFAILALLTLPDSGRTPDDERGSGHFWPYVVFALAQGALQIVLQQVHYQLYSGSP
MLILLTIAGVGALAWFAYHQWNHPTPLVRLHAFRERTFQVGLLLYMFYYYESTGFSYLTSRFLEGGLGYPVENAGRLVGT
MSLISATALFAYLRYAKFVTHKKWFVVPGFAIAITAALWMTRMTPQVGEAALIVPLLLRGLLLLFIVLPVANLTFRIFAI
DEYTHGYRLKNIVRQLTISFATSSVIIVEQHRVALHQTRLVERANVFDPVFQQTVDTLTRSYAAAGHALNEAHGLAIASI
ARMVAQQASFLASLDGFYFLAGVALVGGLFAAWQKEID
>Mature_517_residues
SAMPGRSPLWSRANLRADLFPWALALVTGIDYFDNAVFSFFASYIAGGINASPDELVWSSSAYAVTAVLGILQQQWWVDR
LGHRRYVAGCMLMFSFGAIAAALADTSLELAFARGFQGYFIGPMMGACRILIQVSFKPQERPPATRAFLIMILLGSALAP
IVGGLLVAHSTWRALFACSAPAGIAFAILALLTLPDSGRTPDDERGSGHFWPYVVFALAQGALQIVLQQVHYQLYSGSPM
LILLTIAGVGALAWFAYHQWNHPTPLVRLHAFRERTFQVGLLLYMFYYYESTGFSYLTSRFLEGGLGYPVENAGRLVGTM
SLISATALFAYLRYAKFVTHKKWFVVPGFAIAITAALWMTRMTPQVGEAALIVPLLLRGLLLLFIVLPVANLTFRIFAID
EYTHGYRLKNIVRQLTISFATSSVIIVEQHRVALHQTRLVERANVFDPVFQQTVDTLTRSYAAAGHALNEAHGLAIASIA
RMVAQQASFLASLDGFYFLAGVALVGGLFAAWQKEID

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=455, Percent_Identity=22.8571428571429, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789042, Length=488, Percent_Identity=22.1311475409836, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790195, Length=429, Percent_Identity=23.3100233100233, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081983, Length=265, Percent_Identity=24.5283018867925, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56961; Mature: 56830

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAMPGRSPLWSRANLRADLFPWALALVTGIDYFDNAVFSFFASYIAGGINASPDELVWS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEC
SSAYAVTAVLGILQQQWWVDRLGHRRYVAGCMLMFSFGAIAAALADTSLELAFARGFQGY
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
FIGPMMGACRILIQVSFKPQERPPATRAFLIMILLGSALAPIVGGLLVAHSTWRALFACS
EHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APAGIAFAILALLTLPDSGRTPDDERGSGHFWPYVVFALAQGALQIVLQQVHYQLYSGSP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MLILLTIAGVGALAWFAYHQWNHPTPLVRLHAFRERTFQVGLLLYMFYYYESTGFSYLTS
CEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RFLEGGLGYPVENAGRLVGTMSLISATALFAYLRYAKFVTHKKWFVVPGFAIAITAALWM
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
TRMTPQVGEAALIVPLLLRGLLLLFIVLPVANLTFRIFAIDEYTHGYRLKNIVRQLTISF
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHH
ATSSVIIVEQHRVALHQTRLVERANVFDPVFQQTVDTLTRSYAAAGHALNEAHGLAIASI
HCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARMVAQQASFLASLDGFYFLAGVALVGGLFAAWQKEID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAMPGRSPLWSRANLRADLFPWALALVTGIDYFDNAVFSFFASYIAGGINASPDELVWS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEC
SSAYAVTAVLGILQQQWWVDRLGHRRYVAGCMLMFSFGAIAAALADTSLELAFARGFQGY
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
FIGPMMGACRILIQVSFKPQERPPATRAFLIMILLGSALAPIVGGLLVAHSTWRALFACS
EHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APAGIAFAILALLTLPDSGRTPDDERGSGHFWPYVVFALAQGALQIVLQQVHYQLYSGSP
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MLILLTIAGVGALAWFAYHQWNHPTPLVRLHAFRERTFQVGLLLYMFYYYESTGFSYLTS
CEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RFLEGGLGYPVENAGRLVGTMSLISATALFAYLRYAKFVTHKKWFVVPGFAIAITAALWM
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
TRMTPQVGEAALIVPLLLRGLLLLFIVLPVANLTFRIFAIDEYTHGYRLKNIVRQLTISF
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHH
ATSSVIIVEQHRVALHQTRLVERANVFDPVFQQTVDTLTRSYAAAGHALNEAHGLAIASI
HCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARMVAQQASFLASLDGFYFLAGVALVGGLFAAWQKEID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]