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The map label for this gene is betA [H]

Identifier: 78066384

GI number: 78066384

Start: 1936218

End: 1937828

Strand: Reverse

Name: betA [H]

Synonym: Bcep18194_A4914

Alternate gene names: 78066384

Gene position: 1937828-1936218 (Counterclockwise)

Preceding gene: 78066385

Following gene: 78066383

Centisome position: 52.46

GC content: 67.6

Gene sequence:

>1611_bases
ATGAAAGTATCAAGACGTCAGGTTCTGGTGGCCGGCGCGGCCGCCGCGATGGCGGCGCTTGCAGGCAAGGTCTCGGCCAG
CACGCAATCCGGAAAGAAGTCACGACACTTCGACGTGGTGATCGTCGGCGGCGGATCGGCCGGCGCCGTACTGGCCGCCC
GGCTGAGTGCGGACCCGCGGCGCAGCGTGCTGCTGCTGGAAGCCGGACCGAATTTCGCGCCCGGCAGCTACCCCGAGGTA
CTGACGAATGCCAACGTCGTCGCCGGCTCCCCGGCGTACGACTGGCATTACCACACCGAGGACGCGGCCCGGCTCGGCCA
TGATATCCCGGTGCCGCGCGGCCGCGTCGTCGGCGGCAGCTCGGCCGTCAATGCCGCAGTGGCCATGCGCGCCCGCCCTG
CCGACTTCGCGCGCTGGTCCGCCCGCGGCATCGAAGGATGGTCGTGGGAAGCCGTGCTCGACGCGTACAAGGCATTGGAG
AACACGCCGGCCGGCGACGATGCCTGGCACGGCCGCGACGGCCCGTTCCCGATCCGACAACGGACTGCAGCCGACAACAC
GCCGTCGATGCGCGCATTCGTCGAAGGCTCGCAAGCGCTCGGCATGCGGCGCGTGCCGGACCTGAACGGCGCTGACCCTC
AAGGCGTCGGCTACTACGCACTCAACGTCGTCGACGGCGTGCGCGTAAATACCGGTATCGCCTACCTGACTACCGCGGTA
CGCGCCCGTTCGAACCTCACGATTCGCGGCGACGCGGAAGTCGACAGCGTCGTCATCCGGCACAAACGTGCAGCCGGCGT
CGCGCTCGTCGGCGGCGAAGTCATCCCGGCCGGCGAGGTCGTCCTCGCATCTGGTGCGTTCGGCAGCCCGGCGATCCTGA
TGCGCTCGGGCATCGGGCCTCAATCGCATCTGTCGGAGCTGGGCATCGCCACCGTCTCCGATCTGCCGGTCGGGAACCGA
CTGCAGGACCACCCGTTCTTCTACAACGTCTACGCACTGAAGCGCGAAGCGAACGCGATGACGCCCGCCGCCGGCGCGAT
CGTCTGGACGCCGTCGCAAAGCGCGAAGCCGGGTGAGCTCGACCTGCAGATCTCGGCCACGCACCTGATCGACCCGAAGG
TCAGCCCGACTGGCGGCGCAATTGTGCTGGCCTGCGCGGTCACGCTGCCCAGATCGCTCGGCCAGTTGCGGCTGGCAAGC
CGCGATCCGCGTATCGCGCCACATATTCGCTACAACTTCTTCAGCGACACGAACGACCTCGACCGGATGGTCGAGGCGGT
CCAGCTGTCGCGAGAGATCGGCCGAACAGCCCCCTTCTCGTCGCTTGTCGATCACGAGATGGCACCGGGTGCCGGCATCA
GCGCCAACGATCCGGCCGCGTTGCGCGCCAACATCATCGCCAACGCCGCCGCCTACCTGCACCCGACGTCGACGGTACCG
ATGGGGGCCGAGTCGGATCCTTCCGCCGTCGTTGACCCATTGGGCCGTGTACGCGGCGTCGAAGCATTGCGGGTAGTCGA
TGCATCGATCATGCCGGAGATCCCGTCGGTGCCAACGAACGTGACGACCATCATGCTTGCCGAGCGTATCGCCGCGACGA
TGACGGCATGA

Upstream 100 bases:

>100_bases
TCCATACGTCTGAATCCATTCTGTAGTTACGGCCGGTCGATACCGATCGACGAGCGCTCCGGGCCACATCGCGTCCGGGG
GCATGGACAGGAGTTGGATC

Downstream 100 bases:

>100_bases
GCATGCCGCGCTCGTAATCGGCAAACAGATATCTCACCAGCGAACCGATCAATCATTATTGATCAGTACTTCAAACATTA
TCTGAACGGAACATCACGTT

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MKVSRRQVLVAGAAAAMAALAGKVSASTQSGKKSRHFDVVIVGGGSAGAVLAARLSADPRRSVLLLEAGPNFAPGSYPEV
LTNANVVAGSPAYDWHYHTEDAARLGHDIPVPRGRVVGGSSAVNAAVAMRARPADFARWSARGIEGWSWEAVLDAYKALE
NTPAGDDAWHGRDGPFPIRQRTAADNTPSMRAFVEGSQALGMRRVPDLNGADPQGVGYYALNVVDGVRVNTGIAYLTTAV
RARSNLTIRGDAEVDSVVIRHKRAAGVALVGGEVIPAGEVVLASGAFGSPAILMRSGIGPQSHLSELGIATVSDLPVGNR
LQDHPFFYNVYALKREANAMTPAAGAIVWTPSQSAKPGELDLQISATHLIDPKVSPTGGAIVLACAVTLPRSLGQLRLAS
RDPRIAPHIRYNFFSDTNDLDRMVEAVQLSREIGRTAPFSSLVDHEMAPGAGISANDPAALRANIIANAAAYLHPTSTVP
MGAESDPSAVVDPLGRVRGVEALRVVDASIMPEIPSVPTNVTTIMLAERIAATMTA

Sequences:

>Translated_536_residues
MKVSRRQVLVAGAAAAMAALAGKVSASTQSGKKSRHFDVVIVGGGSAGAVLAARLSADPRRSVLLLEAGPNFAPGSYPEV
LTNANVVAGSPAYDWHYHTEDAARLGHDIPVPRGRVVGGSSAVNAAVAMRARPADFARWSARGIEGWSWEAVLDAYKALE
NTPAGDDAWHGRDGPFPIRQRTAADNTPSMRAFVEGSQALGMRRVPDLNGADPQGVGYYALNVVDGVRVNTGIAYLTTAV
RARSNLTIRGDAEVDSVVIRHKRAAGVALVGGEVIPAGEVVLASGAFGSPAILMRSGIGPQSHLSELGIATVSDLPVGNR
LQDHPFFYNVYALKREANAMTPAAGAIVWTPSQSAKPGELDLQISATHLIDPKVSPTGGAIVLACAVTLPRSLGQLRLAS
RDPRIAPHIRYNFFSDTNDLDRMVEAVQLSREIGRTAPFSSLVDHEMAPGAGISANDPAALRANIIANAAAYLHPTSTVP
MGAESDPSAVVDPLGRVRGVEALRVVDASIMPEIPSVPTNVTTIMLAERIAATMTA
>Mature_536_residues
MKVSRRQVLVAGAAAAMAALAGKVSASTQSGKKSRHFDVVIVGGGSAGAVLAARLSADPRRSVLLLEAGPNFAPGSYPEV
LTNANVVAGSPAYDWHYHTEDAARLGHDIPVPRGRVVGGSSAVNAAVAMRARPADFARWSARGIEGWSWEAVLDAYKALE
NTPAGDDAWHGRDGPFPIRQRTAADNTPSMRAFVEGSQALGMRRVPDLNGADPQGVGYYALNVVDGVRVNTGIAYLTTAV
RARSNLTIRGDAEVDSVVIRHKRAAGVALVGGEVIPAGEVVLASGAFGSPAILMRSGIGPQSHLSELGIATVSDLPVGNR
LQDHPFFYNVYALKREANAMTPAAGAIVWTPSQSAKPGELDLQISATHLIDPKVSPTGGAIVLACAVTLPRSLGQLRLAS
RDPRIAPHIRYNFFSDTNDLDRMVEAVQLSREIGRTAPFSSLVDHEMAPGAGISANDPAALRANIIANAAAYLHPTSTVP
MGAESDPSAVVDPLGRVRGVEALRVVDASIMPEIPSVPTNVTTIMLAERIAATMTA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=562, Percent_Identity=34.8754448398576, Blast_Score=256, Evalue=4e-68,
Organism=Escherichia coli, GI1786503, Length=540, Percent_Identity=34.0740740740741, Blast_Score=242, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17532301, Length=552, Percent_Identity=30.7971014492754, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24642042, Length=562, Percent_Identity=31.1387900355872, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI18859995, Length=557, Percent_Identity=30.3411131059246, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24642039, Length=561, Percent_Identity=30.4812834224599, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI18859993, Length=578, Percent_Identity=29.4117647058824, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI45551458, Length=568, Percent_Identity=29.9295774647887, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI45549471, Length=571, Percent_Identity=30.2977232924694, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17137792, Length=559, Percent_Identity=28.4436493738819, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24642051, Length=573, Percent_Identity=29.8429319371728, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24642059, Length=564, Percent_Identity=28.9007092198582, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24650267, Length=560, Percent_Identity=27.1428571428571, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24642048, Length=304, Percent_Identity=35.8552631578947, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24642055, Length=309, Percent_Identity=35.5987055016181, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24642037, Length=316, Percent_Identity=34.1772151898734, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24642035, Length=311, Percent_Identity=32.7974276527331, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24642057, Length=578, Percent_Identity=25.7785467128028, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 56052; Mature: 56052

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSRRQVLVAGAAAAMAALAGKVSASTQSGKKSRHFDVVIVGGGSAGAVLAARLSADPR
CCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCC
RSVLLLEAGPNFAPGSYPEVLTNANVVAGSPAYDWHYHTEDAARLGHDIPVPRGRVVGGS
CEEEEEECCCCCCCCCCHHHHCCCCEEECCCCCCCEECCCHHHHCCCCCCCCCCEEECCC
SAVNAAVAMRARPADFARWSARGIEGWSWEAVLDAYKALENTPAGDDAWHGRDGPFPIRQ
HHHHHHHHEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
RTAADNTPSMRAFVEGSQALGMRRVPDLNGADPQGVGYYALNVVDGVRVNTGIAYLTTAV
CCCCCCCCCHHEEECCHHHCCCCCCCCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHH
RARSNLTIRGDAEVDSVVIRHKRAAGVALVGGEVIPAGEVVLASGAFGSPAILMRSGIGP
HHCCCEEEECCCCHHHHHHHHHCCCCEEEECCEECCCCCEEEECCCCCCCHHEEECCCCC
QSHLSELGIATVSDLPVGNRLQDHPFFYNVYALKREANAMTPAAGAIVWTPSQSAKPGEL
HHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEECCCCCCCCCCE
DLQISATHLIDPKVSPTGGAIVLACAVTLPRSLGQLRLASRDPRIAPHIRYNFFSDTNDL
EEEEEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCHHH
DRMVEAVQLSREIGRTAPFSSLVDHEMAPGAGISANDPAALRANIIANAAAYLHPTSTVP
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCC
MGAESDPSAVVDPLGRVRGVEALRVVDASIMPEIPSVPTNVTTIMLAERIAATMTA
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVSRRQVLVAGAAAAMAALAGKVSASTQSGKKSRHFDVVIVGGGSAGAVLAARLSADPR
CCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCC
RSVLLLEAGPNFAPGSYPEVLTNANVVAGSPAYDWHYHTEDAARLGHDIPVPRGRVVGGS
CEEEEEECCCCCCCCCCHHHHCCCCEEECCCCCCCEECCCHHHHCCCCCCCCCCEEECCC
SAVNAAVAMRARPADFARWSARGIEGWSWEAVLDAYKALENTPAGDDAWHGRDGPFPIRQ
HHHHHHHHEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
RTAADNTPSMRAFVEGSQALGMRRVPDLNGADPQGVGYYALNVVDGVRVNTGIAYLTTAV
CCCCCCCCCHHEEECCHHHCCCCCCCCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHH
RARSNLTIRGDAEVDSVVIRHKRAAGVALVGGEVIPAGEVVLASGAFGSPAILMRSGIGP
HHCCCEEEECCCCHHHHHHHHHCCCCEEEECCEECCCCCEEEECCCCCCCHHEEECCCCC
QSHLSELGIATVSDLPVGNRLQDHPFFYNVYALKREANAMTPAAGAIVWTPSQSAKPGEL
HHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEECCCCCCCCCCE
DLQISATHLIDPKVSPTGGAIVLACAVTLPRSLGQLRLASRDPRIAPHIRYNFFSDTNDL
EEEEEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCHHH
DRMVEAVQLSREIGRTAPFSSLVDHEMAPGAGISANDPAALRANIIANAAAYLHPTSTVP
HHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCC
MGAESDPSAVVDPLGRVRGVEALRVVDASIMPEIPSVPTNVTTIMLAERIAATMTA
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA