| Definition | Burkholderia sp. 383 chromosome 1, complete genome. |
|---|---|
| Accession | NC_007510 |
| Length | 3,694,126 |
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The map label for this gene is pldh-t [H]
Identifier: 78066381
GI number: 78066381
Start: 1932843
End: 1933583
Strand: Reverse
Name: pldh-t [H]
Synonym: Bcep18194_A4911
Alternate gene names: 78066381
Gene position: 1933583-1932843 (Counterclockwise)
Preceding gene: 78066382
Following gene: 78066380
Centisome position: 52.34
GC content: 63.56
Gene sequence:
>741_bases ATGAGCACCCATCGCAAAGTAGCAGTCGTCACCGGCGCGGCACAGGGCTTCGGCCAGGCCATCAGCGTCGGCCTGGCCGG TCGCGGCATCGACATTGTCGCCGTCGACCTCGCTGAATCCGATGCCACGGTCGCGGCAGTCGAGCGTGCCGGCGCACGTG CCGTCAGCCTCGTCGCCGACGTGTCGGATCCCGCATCGGTCGAGCGCCTGTCTGCGCTGCTGAAAGCAGAATTCGGCCGC TGCGACATTCTCGTCAACAACGCGGGCATCTATCCGAACGTTTCGTTCGCCGACGTCGATTACGCGCTGTGGCAACGCGT GCACCGGGTCAATCTCGATTCCCAGTTCCTGATGGTGAAGGCCGTACTCCCCTTCATGATCGAACGCAGCTGGGGCCGCA TCGTTAACATCACGTCGAATTCGGTCGGGCTCGTTGCGACGGGCCTGTCGCACTATATGTCGAGCAAGGCTGGTGTCATC GGCTTCACGCGCGGTCTCGCAACAGACGTCGCGGAGCACGGGATTACCGTCAATGCAGTTGGCCCGACCGCTTCGCTGAC GACCGGCGGCAAGACACATATCAAGCGAGAGCACATCGAAGCGCTGGCTCAGGCGCAAGCGATCAAGCGCCCGGGCGCCG CCGAAGACATCGTTGGCACGGTGCTGTTCCTGTCGAGCGACGACAGTGCGTTCGTCACCGGGCAGACGATCATCGCGGAT GGCGGGCTGGTCAGGCTGTAA
Upstream 100 bases:
>100_bases GCCCGATGAGCGCGCCGCGATCAATCACGGCAATGCGTTGCAACTTTTCCCGCGACTCGCACCCCGTCCGTAACGAAGAA TCCAACAGGAGATGAACATC
Downstream 100 bases:
>100_bases GCGCTGAACCACTCCGACTCGGAATGGCAATGGATCCGGAAGACAGCGACGTGCGACGGCGGGGATCCGCCGCGGCTCCA CTCCGGACGTCCTGTCCATT
Product: Short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: tPLDH [H]
Number of amino acids: Translated: 246; Mature: 245
Protein sequence:
>246_residues MSTHRKVAVVTGAAQGFGQAISVGLAGRGIDIVAVDLAESDATVAAVERAGARAVSLVADVSDPASVERLSALLKAEFGR CDILVNNAGIYPNVSFADVDYALWQRVHRVNLDSQFLMVKAVLPFMIERSWGRIVNITSNSVGLVATGLSHYMSSKAGVI GFTRGLATDVAEHGITVNAVGPTASLTTGGKTHIKREHIEALAQAQAIKRPGAAEDIVGTVLFLSSDDSAFVTGQTIIAD GGLVRL
Sequences:
>Translated_246_residues MSTHRKVAVVTGAAQGFGQAISVGLAGRGIDIVAVDLAESDATVAAVERAGARAVSLVADVSDPASVERLSALLKAEFGR CDILVNNAGIYPNVSFADVDYALWQRVHRVNLDSQFLMVKAVLPFMIERSWGRIVNITSNSVGLVATGLSHYMSSKAGVI GFTRGLATDVAEHGITVNAVGPTASLTTGGKTHIKREHIEALAQAQAIKRPGAAEDIVGTVLFLSSDDSAFVTGQTIIAD GGLVRL >Mature_245_residues STHRKVAVVTGAAQGFGQAISVGLAGRGIDIVAVDLAESDATVAAVERAGARAVSLVADVSDPASVERLSALLKAEFGRC DILVNNAGIYPNVSFADVDYALWQRVHRVNLDSQFLMVKAVLPFMIERSWGRIVNITSNSVGLVATGLSHYMSSKAGVIG FTRGLATDVAEHGITVNAVGPTASLTTGGKTHIKREHIEALAQAQAIKRPGAAEDIVGTVLFLSSDDSAFVTGQTIIADG GLVRL
Specific function: Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone, but does not have activity toward pyridoxal 5'-phosphate, pyridoxine, pyridoxamine, pyridoxamine 5'-phosphat
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=241, Percent_Identity=33.195020746888, Blast_Score=116, Evalue=2e-26, Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=32.5301204819277, Blast_Score=101, Evalue=8e-22, Organism=Homo sapiens, GI66933014, Length=245, Percent_Identity=32.6530612244898, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=31.0204081632653, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI4504505, Length=191, Percent_Identity=32.4607329842932, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI126723750, Length=245, Percent_Identity=29.7959183673469, Blast_Score=88, Evalue=6e-18, Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=32.0833333333333, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=31.1203319502075, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=28.968253968254, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI7706318, Length=189, Percent_Identity=32.2751322751323, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI226371731, Length=182, Percent_Identity=33.5164835164835, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI210032110, Length=183, Percent_Identity=30.6010928961749, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI126723191, Length=199, Percent_Identity=32.1608040201005, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI40807363, Length=184, Percent_Identity=30.9782608695652, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4758504, Length=192, Percent_Identity=33.8541666666667, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI31542939, Length=213, Percent_Identity=30.0469483568075, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI4557649, Length=184, Percent_Identity=30.9782608695652, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI10190704, Length=245, Percent_Identity=29.3877551020408, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI142976729, Length=174, Percent_Identity=30.4597701149425, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI59889578, Length=226, Percent_Identity=27.4336283185841, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI83715985, Length=185, Percent_Identity=33.5135135135135, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI33667109, Length=180, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI310128830, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI310115468, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI25282469, Length=208, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI40548397, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=4e-11, Organism=Homo sapiens, GI214010158, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=4e-11, Organism=Homo sapiens, GI214010156, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=4e-11, Organism=Homo sapiens, GI22758144, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=4e-11, Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=38.2716049382716, Blast_Score=149, Evalue=1e-37, Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=35.2, Blast_Score=128, Evalue=4e-31, Organism=Escherichia coli, GI1790717, Length=242, Percent_Identity=31.404958677686, Blast_Score=117, Evalue=7e-28, Organism=Escherichia coli, GI87082100, Length=246, Percent_Identity=34.1463414634146, Blast_Score=116, Evalue=1e-27, Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=6e-23, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=30.2040816326531, Blast_Score=98, Evalue=4e-22, Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=29.0196078431373, Blast_Score=97, Evalue=7e-22, Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=31.3725490196078, Blast_Score=93, Evalue=1e-20, Organism=Escherichia coli, GI1789378, Length=241, Percent_Identity=29.045643153527, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=28.9795918367347, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI1786812, Length=255, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=6e-15, Organism=Escherichia coli, GI1787820, Length=177, Percent_Identity=30.5084745762712, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI2367365, Length=238, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-12, Organism=Escherichia coli, GI1787526, Length=244, Percent_Identity=26.2295081967213, Blast_Score=61, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=36.734693877551, Blast_Score=123, Evalue=9e-29, Organism=Caenorhabditis elegans, GI25147288, Length=241, Percent_Identity=33.6099585062241, Blast_Score=104, Evalue=3e-23, Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=30.6201550387597, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=30.1158301158301, Blast_Score=100, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=30.241935483871, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17568967, Length=194, Percent_Identity=33.5051546391753, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=31.8181818181818, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17562906, Length=256, Percent_Identity=29.296875, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17560150, Length=255, Percent_Identity=28.6274509803922, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17563726, Length=254, Percent_Identity=27.9527559055118, Blast_Score=89, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17562990, Length=254, Percent_Identity=29.1338582677165, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI72000259, Length=255, Percent_Identity=30.5882352941176, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17560332, Length=257, Percent_Identity=31.9066147859922, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=28.735632183908, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17538486, Length=257, Percent_Identity=31.1284046692607, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=30, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=29.1828793774319, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI193203117, Length=167, Percent_Identity=31.1377245508982, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI193203115, Length=167, Percent_Identity=31.1377245508982, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17564282, Length=186, Percent_Identity=29.0322580645161, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17562904, Length=257, Percent_Identity=28.0155642023346, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17562908, Length=257, Percent_Identity=28.0155642023346, Blast_Score=79, Evalue=1e-15, Organism=Caenorhabditis elegans, GI193204405, Length=256, Percent_Identity=28.125, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17508895, Length=184, Percent_Identity=28.2608695652174, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17560676, Length=242, Percent_Identity=26.0330578512397, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=29.1187739463602, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=26.6917293233083, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17551412, Length=259, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=27.8350515463918, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17565030, Length=265, Percent_Identity=30.5660377358491, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17558628, Length=195, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17538182, Length=257, Percent_Identity=27.6264591439689, Blast_Score=67, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17536025, Length=253, Percent_Identity=27.6679841897233, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=241, Percent_Identity=29.8755186721992, Blast_Score=100, Evalue=3e-22, Organism=Saccharomyces cerevisiae, GI6322226, Length=179, Percent_Identity=27.9329608938547, Blast_Score=62, Evalue=6e-11, Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=31.8181818181818, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=33.6032388663968, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=27.8884462151394, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=33.7349397590361, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI18859837, Length=191, Percent_Identity=34.5549738219895, Blast_Score=95, Evalue=3e-20, Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=32.3770491803279, Blast_Score=92, Evalue=3e-19, Organism=Drosophila melanogaster, GI24644337, Length=214, Percent_Identity=30.8411214953271, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=32.7485380116959, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI21357673, Length=191, Percent_Identity=28.7958115183246, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24584748, Length=178, Percent_Identity=33.7078651685393, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI161076933, Length=178, Percent_Identity=33.7078651685393, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24640492, Length=169, Percent_Identity=27.810650887574, Blast_Score=74, Evalue=8e-14, Organism=Drosophila melanogaster, GI24581726, Length=172, Percent_Identity=31.3953488372093, Blast_Score=72, Evalue=2e-13, Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=32.3076923076923, Blast_Score=71, Evalue=8e-13, Organism=Drosophila melanogaster, GI281364892, Length=172, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=29.1497975708502, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24584744, Length=185, Percent_Identity=31.3513513513514, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI28574402, Length=185, Percent_Identity=31.3513513513514, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI24640442, Length=183, Percent_Identity=32.2404371584699, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.107 [H]
Molecular weight: Translated: 25623; Mature: 25491
Theoretical pI: Translated: 6.80; Mature: 6.80
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 1.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTHRKVAVVTGAAQGFGQAISVGLAGRGIDIVAVDLAESDATVAAVERAGARAVSLVAD CCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHCCCCEEEEEEC VSDPASVERLSALLKAEFGRCDILVNNAGIYPNVSFADVDYALWQRVHRVNLDSQFLMVK CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCHHHHHHHHHHCCCCCHHHHHH AVLPFMIERSWGRIVNITSNSVGLVATGLSHYMSSKAGVIGFTRGLATDVAEHGITVNAV HHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHCCCCCEEEEHHHHHHHHHHCCEEEEEC GPTASLTTGGKTHIKREHIEALAQAQAIKRPGAAEDIVGTVLFLSSDDSAFVTGQTIIAD CCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCCEEEECCEEEEC GGLVRL CCEEEC >Mature Secondary Structure STHRKVAVVTGAAQGFGQAISVGLAGRGIDIVAVDLAESDATVAAVERAGARAVSLVAD CCCCEEEEEECCCCCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHCCCCEEEEEEC VSDPASVERLSALLKAEFGRCDILVNNAGIYPNVSFADVDYALWQRVHRVNLDSQFLMVK CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHCHHHHHHHHHHCCCCCHHHHHH AVLPFMIERSWGRIVNITSNSVGLVATGLSHYMSSKAGVIGFTRGLATDVAEHGITVNAV HHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHCCCCCEEEEHHHHHHHHHHCCEEEEEC GPTASLTTGGKTHIKREHIEALAQAQAIKRPGAAEDIVGTVLFLSSDDSAFVTGQTIIAD CCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEEECCCCEEEECCEEEEC GGLVRL CCEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11214968 [H]