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The map label for this gene is yngG [H]

Identifier: 78066323

GI number: 78066323

Start: 1871172

End: 1872137

Strand: Direct

Name: yngG [H]

Synonym: Bcep18194_A4853

Alternate gene names: 78066323

Gene position: 1871172-1872137 (Clockwise)

Preceding gene: 78066322

Following gene: 78066324

Centisome position: 50.65

GC content: 69.46

Gene sequence:

>966_bases
ATGAGCGGGCAACAACGCAAACGGCTCTACATCCACGAAGTCGCGACGCGCGACGGCTTCCAGAACGAAGCGGCGTTCGT
CGACACCGACGACAAGATCGCGCTCGTCGACGCGCTGAGCGCGTGCGGCTACGCGAAGATCGAAGTCACGTCGTTCACGT
CGCCGAAGGCGATCCCCGCGTTGCGCGACGCGGAGGCCGTGATGCACGGCATCGCGCGCGCACCGGGTGTCGTCTATACG
GTGCTCGTGCCGAACGTGCGCGGTGCCGAGCGCGCGCTGTCGTGCGGCGTCGACGAAGTGAACCTCGTGATGTCGATGAG
CGAGAGCCACAACCGCGCGAACCTGCGGATGACGCGCGAGCAATCGTTCGCGCAGCTGCGCGACGTGATCGACGCGGTAC
GCGGCACGGGTGTCGCGATCAACGTGTCGCTGTCGACCGCGATGGGCTGCCCGATGGAAGGCGACGTGCCGGCCGAGGGT
GTGCTCGCCTGGATGCACCGCTTCGCGGATCTCGGCGTGCATGGCTTCACGCTGTGCGATACGACCGGCATGGCATTTCC
GTCGCAGGTGCGCGACCTGTCGGCGCGGGCACGCGAGCGCTTCGCCGCGCTGCAGCTCACGCTGCACTTCCACAACACGC
GCGGCATGGCGCTCGCGAACACGCTCGCGGCACTCGACGCCGGGATCGACCGCTTCGACGCATCGCTCGGCGGGCTCGGC
GGCTGCCCGTACGCGCCGGGCGCGACCGGCAACGCGTGCACCGAAGAACTCGTGCACATGCTCGAACTCGACGGCTACGA
TACGGGCGTCGATCTCGCAGCCGTGCTGGCCGCGTCGGCCCGGCTGCCCGCGCTGATCGGGCATGACGTGCCGAGCCAGA
TCCTGAAGGCCGGGCGCCGCTCGGACCTTCATCCGCCGCCGCGCGCGGACGCCGGCGACATGCCCGCGCAGCGCGCGTTC
TCATGA

Upstream 100 bases:

>100_bases
ATACCGACGCGGTACTCGAATCGCTCGGCATCGATGCGGCGACGCGCGGCGACTGGCGCACGCGCGGCGTGATCTGACAA
GCGGAACAGGAGAAGACAAC

Downstream 100 bases:

>100_bases
ACCACGAACAGGAGCCAATCTCATGGCGCTGATTGACCACCTCGACCATCTCGTGCTGACCTGCGTCGATCCCGACAAGA
CCAGGCATTTCTACACCGAG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSGQQRKRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIARAPGVVYT
VLVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVPAEG
VLAWMHRFADLGVHGFTLCDTTGMAFPSQVRDLSARARERFAALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLG
GCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAASARLPALIGHDVPSQILKAGRRSDLHPPPRADAGDMPAQRAF
S

Sequences:

>Translated_321_residues
MSGQQRKRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIARAPGVVYT
VLVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVPAEG
VLAWMHRFADLGVHGFTLCDTTGMAFPSQVRDLSARARERFAALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLG
GCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAASARLPALIGHDVPSQILKAGRRSDLHPPPRADAGDMPAQRAF
S
>Mature_320_residues
SGQQRKRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIARAPGVVYTV
LVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTREQSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVPAEGV
LAWMHRFADLGVHGFTLCDTTGMAFPSQVRDLSARARERFAALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLGG
CPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAASARLPALIGHDVPSQILKAGRRSDLHPPPRADAGDMPAQRAFS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=295, Percent_Identity=38.6440677966102, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI109150422, Length=287, Percent_Identity=36.9337979094077, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI109150427, Length=287, Percent_Identity=36.9337979094077, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI260654708, Length=135, Percent_Identity=39.2592592592593, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=288, Percent_Identity=36.4583333333333, Blast_Score=193, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6320019, Length=225, Percent_Identity=28, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320071, Length=235, Percent_Identity=27.2340425531915, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24582381, Length=292, Percent_Identity=35.958904109589, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34098; Mature: 33967

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQQRKRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPA
CCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCC
LRDAEAVMHGIARAPGVVYTVLVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTRE
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEHHH
QSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVPAEGVLAWMHRFADLGVHGFTLCD
HHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEC
TTGMAFPSQVRDLSARARERFAALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLG
CCCCCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAASARLPALIGHDVPSQILKAGRR
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCC
SDLHPPPRADAGDMPAQRAFS
CCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SGQQRKRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPA
CCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCC
LRDAEAVMHGIARAPGVVYTVLVPNVRGAERALSCGVDEVNLVMSMSESHNRANLRMTRE
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEHHH
QSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVPAEGVLAWMHRFADLGVHGFTLCD
HHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEC
TTGMAFPSQVRDLSARARERFAALQLTLHFHNTRGMALANTLAALDAGIDRFDASLGGLG
CCCCCCHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GCPYAPGATGNACTEELVHMLELDGYDTGVDLAAVLAASARLPALIGHDVPSQILKAGRR
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCC
SDLHPPPRADAGDMPAQRAFS
CCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]