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The map label for this gene is fadE12 [H]

Identifier: 78066286

GI number: 78066286

Start: 1831405

End: 1832571

Strand: Direct

Name: fadE12 [H]

Synonym: Bcep18194_A4816

Alternate gene names: 78066286

Gene position: 1831405-1832571 (Clockwise)

Preceding gene: 78066285

Following gene: 78066287

Centisome position: 49.58

GC content: 67.95

Gene sequence:

>1167_bases
ATGCAGTTCGACCTGACCGATGACCAGCGCGCGATCGAAAGCGCGATCGAAAAAATCTGCGCACGCTTCGGCGACGAATA
CTGGCTCGAGCGCGATCGCGCGGGCGGGTTTCCGGCCGATTTCCACGCGGCGCTCGCCGAGGCCGGCTGGCTCGGCATCG
CGATGGACCCGGCCCATGGCGGTGCCGGGCTCGGGATGACCGAGGCCGCGCTGATGATGCGCACGATCAGCGCATCGGGC
GCCGGCCTGTCCGGCGCGTCGGCCGTCCACATGAACATCTTCGGGCTGAACCCGGTGCAGGTGTTCGGCACCGACGCGCA
GAAGGCACGTTTCCTGCCGCCGCTGATCGCCGGGCGCGACAAGGCGTGCTTCGCGGTGACCGAACCCGATGCGGGCCTCG
ACACCACGCACCTGACCACGCAGGCCCGCCGCGACGGCGACCACTACGTGCTGAGCGGGCGCAAGATCTGGATCTCGACC
GCGCAGGTCGCGAACAAGATGCTGATCATCGCGCGTACGACGTCGCTCGACCAGGTCGCGAAGCCGACCGACGGGCTGAG
CCTGTTCTATACCGACCTCGACCGGTCGCGCGTCGAGGTGCGCGAGATCGAGAAGATGGGCCGCAAGGCGGTCGATTCGA
ACATGCTGTTCATCGACAACCTGCGCGTGTCGGAAGGCGACCTGATCGGCAACGAAGGCGACGGCTTCCGCTACCTGCTG
CACGGGCTGAATCCGGAACGGATCCTGATCGCCGCGGAGGCGATCGGGCTCGGGCAGGCCGCGCTGCGCCGCGCGACGCA
GTACGCGTGCGAGCGCGTCGTGTTCGGCCGGCCGATCGGGCAGAACCAGTCGATCCAGCATCCGCTCGCGCAGGCGTGGA
TGCAGCTCGAGGCCGCGTGGCTGATGGTGATGAAGGCCGCGACGCGCTACGACGCGGGGCAGTCGTGCGGCGCGGAGGCG
AATGCCGCGAAATACCTCGGCGCGGAAGCCGCGTTCCAGGCGTGCCAGACGGCGGTCGCGACGCACGGCGGGATGGGCTA
CGCGAAGGAATACCATGTCGAGCGCTACCTGCGCGAGTGTATGATTCCGAGGCTCGCGCCCGTGAGTCCGCAACTGATCC
TGTGCTACATCGCGGAGAAGGTGCTCGGGCTGCCGAAGTCGTACTGA

Upstream 100 bases:

>100_bases
CCGCAACGGGACGCGCTTCGGAGCGGAAGGCTCGGTGCCGCCTGGCGTTTTTCATCTTGAGAGCGGCGCGGCCGCTTAGC
CTTTTCCAGGAGAGCATTCC

Downstream 100 bases:

>100_bases
CCGTACCGACCCTGCAGCCGGCCCGGTGCGCGGTTTCCCGTTCCGATTCAAGTGCTCGTCATGGACGTCAAACTCGTTGC
ACGCACGCTCGACCTGTTCG

Product: Acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQFDLTDDQRAIESAIEKICARFGDEYWLERDRAGGFPADFHAALAEAGWLGIAMDPAHGGAGLGMTEAALMMRTISASG
AGLSGASAVHMNIFGLNPVQVFGTDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTSLDQVAKPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVSEGDLIGNEGDGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAWLMVMKAATRYDAGQSCGAEA
NAAKYLGAEAAFQACQTAVATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY

Sequences:

>Translated_388_residues
MQFDLTDDQRAIESAIEKICARFGDEYWLERDRAGGFPADFHAALAEAGWLGIAMDPAHGGAGLGMTEAALMMRTISASG
AGLSGASAVHMNIFGLNPVQVFGTDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTSLDQVAKPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVSEGDLIGNEGDGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAWLMVMKAATRYDAGQSCGAEA
NAAKYLGAEAAFQACQTAVATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY
>Mature_388_residues
MQFDLTDDQRAIESAIEKICARFGDEYWLERDRAGGFPADFHAALAEAGWLGIAMDPAHGGAGLGMTEAALMMRTISASG
AGLSGASAVHMNIFGLNPVQVFGTDAQKARFLPPLIAGRDKACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWIST
AQVANKMLIIARTTSLDQVAKPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVSEGDLIGNEGDGFRYLL
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAWLMVMKAATRYDAGQSCGAEA
NAAKYLGAEAAFQACQTAVATHGGMGYAKEYHVERYLRECMIPRLAPVSPQLILCYIAEKVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=30.4461942257218, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=27.8820375335121, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=27.8820375335121, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI226958412, Length=359, Percent_Identity=28.4122562674095, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4557233, Length=338, Percent_Identity=32.8402366863905, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI226958414, Length=322, Percent_Identity=29.1925465838509, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI7656849, Length=390, Percent_Identity=27.9487179487179, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=28.8515406162465, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501857, Length=330, Percent_Identity=28.7878787878788, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI76496475, Length=339, Percent_Identity=30.0884955752212, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4557235, Length=339, Percent_Identity=30.0884955752212, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=24.9307479224377, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4503943, Length=361, Percent_Identity=24.9307479224377, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI38505218, Length=281, Percent_Identity=27.0462633451957, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI48976061, Length=324, Percent_Identity=25.3086419753086, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI211971008, Length=324, Percent_Identity=25.3086419753086, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=28.1653746770026, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=28.125, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI87082384, Length=304, Percent_Identity=26.9736842105263, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=384, Percent_Identity=30.2083333333333, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=29.4573643410853, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=29.3650793650794, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=27.5132275132275, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=390, Percent_Identity=28.974358974359, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17508101, Length=336, Percent_Identity=30.952380952381, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17538396, Length=360, Percent_Identity=27.7777777777778, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=318, Percent_Identity=29.559748427673, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=30.7420494699647, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=353, Percent_Identity=26.0623229461756, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17534353, Length=361, Percent_Identity=25.4847645429363, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=354, Percent_Identity=25.7062146892655, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=330, Percent_Identity=27.8787878787879, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=28.3898305084746, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982178, Length=228, Percent_Identity=29.3859649122807, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=26.3374485596708, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=161, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=32.6315789473684, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21356377, Length=359, Percent_Identity=31.7548746518106, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=30.6451612903226, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI281363737, Length=381, Percent_Identity=30.7086614173228, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=28.5714285714286, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21355753, Length=320, Percent_Identity=29.6875, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19920834, Length=363, Percent_Identity=25.8953168044077, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42186; Mature: 42186

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDLTDDQRAIESAIEKICARFGDEYWLERDRAGGFPADFHAALAEAGWLGIAMDPAHG
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCC
GAGLGMTEAALMMRTISASGAGLSGASAVHMNIFGLNPVQVFGTDAQKARFLPPLIAGRD
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHCCCHHHCCCC
KACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWISTAQVANKMLIIARTTSLDQVA
CEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCEEEEEHHHHHCEEEEEEECCCHHHHC
KPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVSEGDLIGNEGDGFRYLL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCEECCCCEECCCCCCHHHHH
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAW
HCCCCCEEEEEECHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMVMKAATRYDAGQSCGAEANAAKYLGAEAAFQACQTAVATHGGMGYAKEYHVERYLREC
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIPRLAPVSPQLILCYIAEKVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQFDLTDDQRAIESAIEKICARFGDEYWLERDRAGGFPADFHAALAEAGWLGIAMDPAHG
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCC
GAGLGMTEAALMMRTISASGAGLSGASAVHMNIFGLNPVQVFGTDAQKARFLPPLIAGRD
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHCCCHHHCCCC
KACFAVTEPDAGLDTTHLTTQARRDGDHYVLSGRKIWISTAQVANKMLIIARTTSLDQVA
CEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCEEEEEHHHHHCEEEEEEECCCHHHHC
KPTDGLSLFYTDLDRSRVEVREIEKMGRKAVDSNMLFIDNLRVSEGDLIGNEGDGFRYLL
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCEECCCCEECCCCCCHHHHH
HGLNPERILIAAEAIGLGQAALRRATQYACERVVFGRPIGQNQSIQHPLAQAWMQLEAAW
HCCCCCEEEEEECHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LMVMKAATRYDAGQSCGAEANAAKYLGAEAAFQACQTAVATHGGMGYAKEYHVERYLREC
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
MIPRLAPVSPQLILCYIAEKVLGLPKSY
CCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]