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The map label for this gene is fhuB [H]

Identifier: 78066252

GI number: 78066252

Start: 1780693

End: 1782783

Strand: Direct

Name: fhuB [H]

Synonym: Bcep18194_A4782

Alternate gene names: 78066252

Gene position: 1780693-1782783 (Clockwise)

Preceding gene: 78066251

Following gene: 78066253

Centisome position: 48.2

GC content: 73.84

Gene sequence:

>2091_bases
ATGACGACGCTCGCGATGCGCAAGCGCCTCGCGGCGGCGGGGAAGGGCACGGCGTCGGGCCGGGCCGGCGCGATCGCGCT
CGGCCTCGTCACGTTGATCGCGCTACTCGCGGTGCTGCGCGTCGCCCCCGATCTGCGCGTGTGGTGGGACGCCGTGCCCG
GCAGCGATGCCGCTGCGCTCGCGCACGTGTTCCTGTTCGACCTCAACCTGCCGCGCGTCGCGGCCGCGCTCGTCGCGGGC
GGCTGCCTCGGCATCGCGGGCGCGCTGTTCCAGTCGCTCACGCGCAATCCGCTCGCGTCGCCCGACCTGCTCGGCGTGAC
CGGCGGCGCCCAGCTCGGCCTGCTCGCGGCGATGCTCGTGCCGGCGCTGGCCGGCGTCGCGTCGGTGCCGCTGTTGTTCG
TCTGCGGGCTGGCCGCGGCTGCCTGTGCGATCGTCGCGGCCGGCGGCTGGCGGGCGACGCCGTTGCGCCTCGTGCTCGCG
GGCAGCGTGTGCATGCTGCTGTTCGCGGCGCTGTCGACGCTCGTGCTCGCCTTCTTCGAGCAGAACATCGCGGGCGCCGC
GCTGTGGACCAACGGCAGTCTCTACCAGCCGGGCGCGACGGGCCTCGCGCTTGCCGCGCGCTGGCTCGTCGTGCCGCTGA
TCGCGTTGCCGTTCGTGATCCGGCCGCTGAATCCGCTTACGCTCGGCGACGATGCGGCGGCTGCGGCCGGCGTGCGCGTC
GATGCGACTCGGCTCGCCGCGACAATCGTTGCGGTCGCGTTCACGAGCGTGGCGGTCAGTATCGCGGGCCCGCTGTCGTA
TGTCGGCCTCGTCGCACCGAACCTGCTGCGCCAGGTGCGCGGCGCGCGTGCGGCGCGGCTCGGCGTGCTGGTGCCGCTGT
CGGCGCTCGCGGGCGGTGCGCTCGTGCTCGTCACCGACAGTGCGGTGCTCGCGTCGGGTCTCGACGCCACGCTGTCGACC
GGCGTCGCGATCGCGCTGGTCGGCACGCCGTTGATGCTGGCGATGATCCGGCGCGGTGCCGCGTGGTCGGGCGTGCTGCA
CGCGGATGCCGAACGTGCGGCGGGCAGCGGCTCGACGCGGCTCGTCGGCTGGCTCGAACGGCTCGGCTGGCCGCTGCGCA
CCGCGCTGTTCGTCGTGGCAGGCGTGCTGATCGTGTTCGTCGGCGTGTCGGCCGGCCCCGAGTGGCTGTCGATCGCGCGC
TGGTCCGATGCGCTGTCCGGTCACGATGCGCTCGCGCGGATGCTGATCGACCTGCGGATGCCGCGCCTGCTATGTGCGCT
GCTTGCCGGCGCGTTGCTGGCGGTCAGCGGCGTCGCGATGCAAAGCGTCGTGCGCAATCCGCTCGCGGGCCCCGAAGTGC
TCGGCGTCACGCAGGGTGCGGGGCTCGTCACGCTGTTCGCGCTGTCGACGTGGCCGCTGATGGGCCACGTGACGCTCGCG
GCCGCCGCGCTGATCGGCGGTGGCCTGTCGCTCGCGATCACGCTCGCGCTGAATCACCGGCATCGCTACGCGCCGCTCGC
GGTGGCGTTGACGGGCATCGTGATCGGCGCGCTGTGGACCACGCTCGCGCAATGGTTGATCACGCAGGAAAGCGTGCAGC
CCGCACGCTTCGTCGTGTGGCTCGTCGGCGGTACGTATGGCCGGAGCTGGGGCGAAGTGTCGATGCTGCTGCCGTGGTGC
GTGCTCGCGGTGCCCGTGTTCACGTGGCTCGCGAAACCGCTCGACATGCTCGCGCTCGGCGACGACCAGGCGGCTGCGCT
CGGCTTGCCGGTGGCCGCGCTGCGGCCGCTCGCGCTGACGATCGCGACGCTCGCCGCGTGCGCGGCCGTCGCGGCGGTCG
GGCCGGTCGGCTTCATCGGGTTGATGGCGCCGCACGTCGCGACGATGCTCGGCGCGCGCCGGCATCGTACACGGCTGTGG
CTCGCGGCCGCGTGCGGCGCGCTGATCCTCGGCGTGGCGGATCTCGCGGCGCGTACGGTCGTCGCGCCGCGCGAAGTGCC
GGCCGGCGTGCTGACCGCGCTGATCGGTGCACCGTACCTGCTCGGGCTGTTGATCCTCGAGGGGCGCCGCGCCCGGCGCG
CGGGGCGATGA

Upstream 100 bases:

>100_bases
CGCACCCGCAGACGGGCGCACCGATGTGCGTGCCGGCCTACGGGCCGACGACCGACGGCGCGCCGCAGGCGGCCGGCGTC
TTCGACCGGGATCTCGCCGT

Downstream 100 bases:

>100_bases
CGCCCGCGCTCGATGGCGCGCGCGCCACGCGCTTCTCGACGTTCGGGCCCGAACCGTTCGCCGACCACCTCGACGTCGTG
TGGCTCGGCATGCCGGACGA

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MTTLAMRKRLAAAGKGTASGRAGAIALGLVTLIALLAVLRVAPDLRVWWDAVPGSDAAALAHVFLFDLNLPRVAAALVAG
GCLGIAGALFQSLTRNPLASPDLLGVTGGAQLGLLAAMLVPALAGVASVPLLFVCGLAAAACAIVAAGGWRATPLRLVLA
GSVCMLLFAALSTLVLAFFEQNIAGAALWTNGSLYQPGATGLALAARWLVVPLIALPFVIRPLNPLTLGDDAAAAAGVRV
DATRLAATIVAVAFTSVAVSIAGPLSYVGLVAPNLLRQVRGARAARLGVLVPLSALAGGALVLVTDSAVLASGLDATLST
GVAIALVGTPLMLAMIRRGAAWSGVLHADAERAAGSGSTRLVGWLERLGWPLRTALFVVAGVLIVFVGVSAGPEWLSIAR
WSDALSGHDALARMLIDLRMPRLLCALLAGALLAVSGVAMQSVVRNPLAGPEVLGVTQGAGLVTLFALSTWPLMGHVTLA
AAALIGGGLSLAITLALNHRHRYAPLAVALTGIVIGALWTTLAQWLITQESVQPARFVVWLVGGTYGRSWGEVSMLLPWC
VLAVPVFTWLAKPLDMLALGDDQAAALGLPVAALRPLALTIATLAACAAVAAVGPVGFIGLMAPHVATMLGARRHRTRLW
LAAACGALILGVADLAARTVVAPREVPAGVLTALIGAPYLLGLLILEGRRARRAGR

Sequences:

>Translated_696_residues
MTTLAMRKRLAAAGKGTASGRAGAIALGLVTLIALLAVLRVAPDLRVWWDAVPGSDAAALAHVFLFDLNLPRVAAALVAG
GCLGIAGALFQSLTRNPLASPDLLGVTGGAQLGLLAAMLVPALAGVASVPLLFVCGLAAAACAIVAAGGWRATPLRLVLA
GSVCMLLFAALSTLVLAFFEQNIAGAALWTNGSLYQPGATGLALAARWLVVPLIALPFVIRPLNPLTLGDDAAAAAGVRV
DATRLAATIVAVAFTSVAVSIAGPLSYVGLVAPNLLRQVRGARAARLGVLVPLSALAGGALVLVTDSAVLASGLDATLST
GVAIALVGTPLMLAMIRRGAAWSGVLHADAERAAGSGSTRLVGWLERLGWPLRTALFVVAGVLIVFVGVSAGPEWLSIAR
WSDALSGHDALARMLIDLRMPRLLCALLAGALLAVSGVAMQSVVRNPLAGPEVLGVTQGAGLVTLFALSTWPLMGHVTLA
AAALIGGGLSLAITLALNHRHRYAPLAVALTGIVIGALWTTLAQWLITQESVQPARFVVWLVGGTYGRSWGEVSMLLPWC
VLAVPVFTWLAKPLDMLALGDDQAAALGLPVAALRPLALTIATLAACAAVAAVGPVGFIGLMAPHVATMLGARRHRTRLW
LAAACGALILGVADLAARTVVAPREVPAGVLTALIGAPYLLGLLILEGRRARRAGR
>Mature_695_residues
TTLAMRKRLAAAGKGTASGRAGAIALGLVTLIALLAVLRVAPDLRVWWDAVPGSDAAALAHVFLFDLNLPRVAAALVAGG
CLGIAGALFQSLTRNPLASPDLLGVTGGAQLGLLAAMLVPALAGVASVPLLFVCGLAAAACAIVAAGGWRATPLRLVLAG
SVCMLLFAALSTLVLAFFEQNIAGAALWTNGSLYQPGATGLALAARWLVVPLIALPFVIRPLNPLTLGDDAAAAAGVRVD
ATRLAATIVAVAFTSVAVSIAGPLSYVGLVAPNLLRQVRGARAARLGVLVPLSALAGGALVLVTDSAVLASGLDATLSTG
VAIALVGTPLMLAMIRRGAAWSGVLHADAERAAGSGSTRLVGWLERLGWPLRTALFVVAGVLIVFVGVSAGPEWLSIARW
SDALSGHDALARMLIDLRMPRLLCALLAGALLAVSGVAMQSVVRNPLAGPEVLGVTQGAGLVTLFALSTWPLMGHVTLAA
AALIGGGLSLAITLALNHRHRYAPLAVALTGIVIGALWTTLAQWLITQESVQPARFVVWLVGGTYGRSWGEVSMLLPWCV
LAVPVFTWLAKPLDMLALGDDQAAALGLPVAALRPLALTIATLAACAAVAAVGPVGFIGLMAPHVATMLGARRHRTRLWL
AAACGALILGVADLAARTVVAPREVPAGVLTALIGAPYLLGLLILEGRRARRAGR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=632, Percent_Identity=31.4873417721519, Blast_Score=187, Evalue=3e-48,
Organism=Escherichia coli, GI1790740, Length=286, Percent_Identity=41.2587412587413, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1788004, Length=309, Percent_Identity=34.9514563106796, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1786804, Length=319, Percent_Identity=34.1692789968652, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1790741, Length=317, Percent_Identity=34.7003154574132, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786805, Length=305, Percent_Identity=32.7868852459016, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70787; Mature: 70656

Theoretical pI: Translated: 11.47; Mature: 11.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLAMRKRLAAAGKGTASGRAGAIALGLVTLIALLAVLRVAPDLRVWWDAVPGSDAAAL
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
AHVFLFDLNLPRVAAALVAGGCLGIAGALFQSLTRNPLASPDLLGVTGGAQLGLLAAMLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHH
PALAGVASVPLLFVCGLAAAACAIVAAGGWRATPLRLVLAGSVCMLLFAALSTLVLAFFE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNIAGAALWTNGSLYQPGATGLALAARWLVVPLIALPFVIRPLNPLTLGDDAAAAAGVRV
HCCCCEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCEE
DATRLAATIVAVAFTSVAVSIAGPLSYVGLVAPNLLRQVRGARAARLGVLVPLSALAGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCE
LVLVTDSAVLASGLDATLSTGVAIALVGTPLMLAMIRRGAAWSGVLHADAERAAGSGSTR
EEEEECCHHHHCCCCHHHHCCEEEEHHHHHHHHHHHHCCCCCCCHHCCCHHHCCCCCCHH
LVGWLERLGWPLRTALFVVAGVLIVFVGVSAGPEWLSIARWSDALSGHDALARMLIDLRM
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
PRLLCALLAGALLAVSGVAMQSVVRNPLAGPEVLGVTQGAGLVTLFALSTWPLMGHVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHH
AAALIGGGLSLAITLALNHRHRYAPLAVALTGIVIGALWTTLAQWLITQESVQPARFVVW
HHHHHCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LVGGTYGRSWGEVSMLLPWCVLAVPVFTWLAKPLDMLALGDDQAAALGLPVAALRPLALT
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCHHHHCCCHHHHHHHHHH
IATLAACAAVAAVGPVGFIGLMAPHVATMLGARRHRTRLWLAAACGALILGVADLAARTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAPREVPAGVLTALIGAPYLLGLLILEGRRARRAGR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure 
TTLAMRKRLAAAGKGTASGRAGAIALGLVTLIALLAVLRVAPDLRVWWDAVPGSDAAAL
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
AHVFLFDLNLPRVAAALVAGGCLGIAGALFQSLTRNPLASPDLLGVTGGAQLGLLAAMLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHH
PALAGVASVPLLFVCGLAAAACAIVAAGGWRATPLRLVLAGSVCMLLFAALSTLVLAFFE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNIAGAALWTNGSLYQPGATGLALAARWLVVPLIALPFVIRPLNPLTLGDDAAAAAGVRV
HCCCCEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCEE
DATRLAATIVAVAFTSVAVSIAGPLSYVGLVAPNLLRQVRGARAARLGVLVPLSALAGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCE
LVLVTDSAVLASGLDATLSTGVAIALVGTPLMLAMIRRGAAWSGVLHADAERAAGSGSTR
EEEEECCHHHHCCCCHHHHCCEEEEHHHHHHHHHHHHCCCCCCCHHCCCHHHCCCCCCHH
LVGWLERLGWPLRTALFVVAGVLIVFVGVSAGPEWLSIARWSDALSGHDALARMLIDLRM
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
PRLLCALLAGALLAVSGVAMQSVVRNPLAGPEVLGVTQGAGLVTLFALSTWPLMGHVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHH
AAALIGGGLSLAITLALNHRHRYAPLAVALTGIVIGALWTTLAQWLITQESVQPARFVVW
HHHHHCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LVGGTYGRSWGEVSMLLPWCVLAVPVFTWLAKPLDMLALGDDQAAALGLPVAALRPLALT
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCHHHHCCCHHHHHHHHHH
IATLAACAAVAAVGPVGFIGLMAPHVATMLGARRHRTRLWLAAACGALILGVADLAARTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAPREVPAGVLTALIGAPYLLGLLILEGRRARRAGR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]