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The map label for this gene is arpR [H]

Identifier: 78066236

GI number: 78066236

Start: 1763247

End: 1763894

Strand: Reverse

Name: arpR [H]

Synonym: Bcep18194_A4766

Alternate gene names: 78066236

Gene position: 1763894-1763247 (Counterclockwise)

Preceding gene: 78066240

Following gene: 78066235

Centisome position: 47.75

GC content: 67.9

Gene sequence:

>648_bases
ATGGCCCGCAAGACCCGCGAAGAATCGCTCGCCATCAAGCACCGGATCCTCGACGCCGCCGAGCTCGTGCTGCTCGAGAA
AGGCGTGGCGCAAACCGCGATGGCGGACCTCGCCGAGGCCGCCGGGATGTCGCGGGGCGCCGTCTACGGCCATTACCGCA
ACAAGATGGAAGTGTGTCTCGCGATGTGCGACCGCGCGTTCGCGCGCACGTCGGAAGGCTTCGACGCGGGCGAAGGGCTG
CCCCCGCTCGCCACGTTGCGGCGCGCCGCGTCGCACTATCTGCAGGAATGCGGCGAGCCGGGCCCGATGCAGCGCGTGCT
CGTGATCCTCTATACGAAGTGCGAGCAGAGCGAGGAAAACGGTGAGTTGCAGCGGCGCCGCATGCTGCTCGAATTGCAGA
TGCTGCGGATCACCAAGGCGCTGCTGCGCCGCGCGATCGCGGCCGGCGAAGTCGCCGCCGATCTCGATGTACACCTGGCC
GCCGTCTATCTCGTCTCGCTGCTCGAAGGCGTGTTCGCGTCGATGATCTGGACCAACCGGCTGCGCGGCAACCTGTGGAA
CGACGCCGAGGCCATGCTCGACGCCAGCTTCGACACCGTGCGCACCTCCGCCGCGCTGCGCATCCGCGCGCACAAATTGC
CGGGCTGA

Upstream 100 bases:

>100_bases
CCGATTATAATCAGTCACGACTGATTAAATACACGGCACTTCAATCTGACCGTCACACTGTCTCAATAAAACGACAGCGA
ACTGTAAGGAATTTCAGGAC

Downstream 100 bases:

>100_bases
CTGAATTTGTCGTAATAAATGCTGATTTAACCCGATTTACCGCACTGTGAAACGAATGAGCTGACCCCCTTTAAAATTTT
TAACGTTTTGCGGAACATCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MARKTREESLAIKHRILDAAELVLLEKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCLAMCDRAFARTSEGFDAGEGL
PPLATLRRAASHYLQECGEPGPMQRVLVILYTKCEQSEENGELQRRRMLLELQMLRITKALLRRAIAAGEVAADLDVHLA
AVYLVSLLEGVFASMIWTNRLRGNLWNDAEAMLDASFDTVRTSAALRIRAHKLPG

Sequences:

>Translated_215_residues
MARKTREESLAIKHRILDAAELVLLEKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCLAMCDRAFARTSEGFDAGEGL
PPLATLRRAASHYLQECGEPGPMQRVLVILYTKCEQSEENGELQRRRMLLELQMLRITKALLRRAIAAGEVAADLDVHLA
AVYLVSLLEGVFASMIWTNRLRGNLWNDAEAMLDASFDTVRTSAALRIRAHKLPG
>Mature_214_residues
ARKTREESLAIKHRILDAAELVLLEKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCLAMCDRAFARTSEGFDAGEGLP
PLATLRRAASHYLQECGEPGPMQRVLVILYTKCEQSEENGELQRRRMLLELQMLRITKALLRRAIAAGEVAADLDVHLAA
VYLVSLLEGVFASMIWTNRLRGNLWNDAEAMLDASFDTVRTSAALRIRAHKLPG

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789664, Length=203, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786669, Length=180, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23782; Mature: 23651

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTREESLAIKHRILDAAELVLLEKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AMCDRAFARTSEGFDAGEGLPPLATLRRAASHYLQECGEPGPMQRVLVILYTKCEQSEEN
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
GELQRRRMLLELQMLRITKALLRRAIAAGEVAADLDVHLAAVYLVSLLEGVFASMIWTNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGNLWNDAEAMLDASFDTVRTSAALRIRAHKLPG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARKTREESLAIKHRILDAAELVLLEKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AMCDRAFARTSEGFDAGEGLPPLATLRRAASHYLQECGEPGPMQRVLVILYTKCEQSEEN
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
GELQRRRMLLELQMLRITKALLRRAIAAGEVAADLDVHLAAVYLVSLLEGVFASMIWTNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGNLWNDAEAMLDASFDTVRTSAALRIRAHKLPG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]