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The map label for this gene is echA8 [H]

Identifier: 78066172

GI number: 78066172

Start: 1697001

End: 1698164

Strand: Direct

Name: echA8 [H]

Synonym: Bcep18194_A4702

Alternate gene names: 78066172

Gene position: 1697001-1698164 (Clockwise)

Preceding gene: 78066171

Following gene: 78066174

Centisome position: 45.94

GC content: 68.3

Gene sequence:

>1164_bases
ATGACCCTCATGACCGATTCCACTTCCGCTGCCGTTTCCGCCGAATCCACTCAGCCCGATGTACGCGCGTATGTCGCGAA
CCGCATCGGCTTTCTCGAACTGAACCGGCCGAAGGCGCTGAACGCGCTGTCGGTCGGCATGATCCGGCTGATGCAGCAGG
CGCTCGACGCGTGGCGCGACGATCCCGAGGTCGTCGCGGTCGTCGTGCACAGCCCGCATCCGCGCGCGTTCTGCGCGGGC
GGCGACGTGCGCTTCTTCCACGATGCGTGGCAGCGCGGCGACCGCGATGCGGTCGACACGTTCTTCATCGAGGAATACAC
GCTCAACCACACGATCTTCGCGTATCCGAAGCCCTATATCGCGCTGATGCACGGCGTCGTGATGGGCGGTGGCATGGGGA
TTTCGCAGGCGGCGCGGCATACGGGCGGCCTGCGTGTCGTGACCGACTCGACGAAGATGGCGATGCCGGAAACGCGTATC
GGCCTGTTCCCGGACGTCGGGATGAGCTGGTTCCTCGCGCGCACGCCGGGTGCGATCGGCCGCTATCTCGCGGTGACCGG
CGCGACGCTCGACGCGGCCGGCGCGCTGTACGCGCAGCTCGCCGACGTCTATCTGCCCGATGCCGCACTGCCGGCGCTGC
TCGATACGCTGCGCAGCGCGCGTATCGACAGCGGCGAGCAGGCCGTTGCGTGCGTGGCCGAGGCAGCCGCCGCGCACAAG
GTCGTGCCGACCCCCGACACGTCGGCGCTGGCCGACGCGCGTACCGGGATCGACCGGCATTTCGCGCAGCCGGACATCGG
CGCGATCCTCGCGTCGCTCGACGCCGACCAGGATTGCGCGGCCGTCGACGGATGGATCGAGAAGGCGACCCATGCGATGC
GCGAACAGTTGTCGCCGTTGTCGATGGCCGTGTCGCTGGAAGTCGTCGAACGCGCACGCGGCGCAACGATGGCCGACTGC
CTGCGGCGCGATCTCGATCTCACGCGCTCGACGTTCGCGCGCGGCGACGTGATCGAAGGCGTGCGCGCGCTGATCGTCGA
CAAGGACCACCAGCCGGTCTGGCGCTTCAAGTCGTCCGCCGATATCGATCGCGCGGACGTGCTCGCGATGTTCGACAGCC
CGTGGGCGCCGGACACGCATCCGCTGCGGAATCTGCAGGACTGA

Upstream 100 bases:

>100_bases
CCGGCCGTGATCGGCCTCGGCCTGATCGTCGCCGGCGTCGTGGTGTTGAACCTGTTTTCGAAGATGCAGGCGCACTGAGC
GTGCGACTGCCATTTGCCGG

Downstream 100 bases:

>100_bases
CGCCGGTCGGACTGACCGAAGCGCGAGCTGGAAACGAAAAGGCCGCCTGCACATGCAGGCGGCCTTTTTCATGGATGTCG
ACCGGTTTGGGGGCGACGAG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MTLMTDSTSAAVSAESTQPDVRAYVANRIGFLELNRPKALNALSVGMIRLMQQALDAWRDDPEVVAVVVHSPHPRAFCAG
GDVRFFHDAWQRGDRDAVDTFFIEEYTLNHTIFAYPKPYIALMHGVVMGGGMGISQAARHTGGLRVVTDSTKMAMPETRI
GLFPDVGMSWFLARTPGAIGRYLAVTGATLDAAGALYAQLADVYLPDAALPALLDTLRSARIDSGEQAVACVAEAAAAHK
VVPTPDTSALADARTGIDRHFAQPDIGAILASLDADQDCAAVDGWIEKATHAMREQLSPLSMAVSLEVVERARGATMADC
LRRDLDLTRSTFARGDVIEGVRALIVDKDHQPVWRFKSSADIDRADVLAMFDSPWAPDTHPLRNLQD

Sequences:

>Translated_387_residues
MTLMTDSTSAAVSAESTQPDVRAYVANRIGFLELNRPKALNALSVGMIRLMQQALDAWRDDPEVVAVVVHSPHPRAFCAG
GDVRFFHDAWQRGDRDAVDTFFIEEYTLNHTIFAYPKPYIALMHGVVMGGGMGISQAARHTGGLRVVTDSTKMAMPETRI
GLFPDVGMSWFLARTPGAIGRYLAVTGATLDAAGALYAQLADVYLPDAALPALLDTLRSARIDSGEQAVACVAEAAAAHK
VVPTPDTSALADARTGIDRHFAQPDIGAILASLDADQDCAAVDGWIEKATHAMREQLSPLSMAVSLEVVERARGATMADC
LRRDLDLTRSTFARGDVIEGVRALIVDKDHQPVWRFKSSADIDRADVLAMFDSPWAPDTHPLRNLQD
>Mature_386_residues
TLMTDSTSAAVSAESTQPDVRAYVANRIGFLELNRPKALNALSVGMIRLMQQALDAWRDDPEVVAVVVHSPHPRAFCAGG
DVRFFHDAWQRGDRDAVDTFFIEEYTLNHTIFAYPKPYIALMHGVVMGGGMGISQAARHTGGLRVVTDSTKMAMPETRIG
LFPDVGMSWFLARTPGAIGRYLAVTGATLDAAGALYAQLADVYLPDAALPALLDTLRSARIDSGEQAVACVAEAAAAHKV
VPTPDTSALADARTGIDRHFAQPDIGAILASLDADQDCAAVDGWIEKATHAMREQLSPLSMAVSLEVVERARGATMADCL
RRDLDLTRSTFARGDVIEGVRALIVDKDHQPVWRFKSSADIDRADVLAMFDSPWAPDTHPLRNLQD

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=349, Percent_Identity=32.378223495702, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI37594469, Length=301, Percent_Identity=32.5581395348837, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI194097323, Length=221, Percent_Identity=30.316742081448, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI221142681, Length=231, Percent_Identity=26.8398268398268, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=354, Percent_Identity=36.4406779661017, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25144157, Length=384, Percent_Identity=35.4166666666667, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320241, Length=211, Percent_Identity=36.4928909952607, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI28571729, Length=379, Percent_Identity=34.5646437994723, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI28571730, Length=379, Percent_Identity=34.5646437994723, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24653139, Length=245, Percent_Identity=29.3877551020408, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 41852; Mature: 41721

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLMTDSTSAAVSAESTQPDVRAYVANRIGFLELNRPKALNALSVGMIRLMQQALDAWRD
CCEECCCCCCEEECCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
DPEVVAVVVHSPHPRAFCAGGDVRFFHDAWQRGDRDAVDTFFIEEYTLNHTIFAYPKPYI
CCCEEEEEEECCCCCEEECCCCCHHHHHHHHCCCCCHHHHHEEEEEEECCEEEECCCHHH
ALMHGVVMGGGMGISQAARHTGGLRVVTDSTKMAMPETRIGLFPDVGMSWFLARTPGAIG
HHHHHHHHCCCCCHHHHHHHCCCEEEEECCCHHCCCCCCCCCCCCCCCCEEECCCCCHHH
RYLAVTGATLDAAGALYAQLADVYLPDAALPALLDTLRSARIDSGEQAVACVAEAAAAHK
HHHEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VVPTPDTSALADARTGIDRHFAQPDIGAILASLDADQDCAAVDGWIEKATHAMREQLSPL
CCCCCCCHHHHHHHHCHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHH
SMAVSLEVVERARGATMADCLRRDLDLTRSTFARGDVIEGVRALIVDKDHQPVWRFKSSA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCCHHHCCCCC
DIDRADVLAMFDSPWAPDTHPLRNLQD
CCCHHHEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLMTDSTSAAVSAESTQPDVRAYVANRIGFLELNRPKALNALSVGMIRLMQQALDAWRD
CEECCCCCCEEECCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
DPEVVAVVVHSPHPRAFCAGGDVRFFHDAWQRGDRDAVDTFFIEEYTLNHTIFAYPKPYI
CCCEEEEEEECCCCCEEECCCCCHHHHHHHHCCCCCHHHHHEEEEEEECCEEEECCCHHH
ALMHGVVMGGGMGISQAARHTGGLRVVTDSTKMAMPETRIGLFPDVGMSWFLARTPGAIG
HHHHHHHHCCCCCHHHHHHHCCCEEEEECCCHHCCCCCCCCCCCCCCCCEEECCCCCHHH
RYLAVTGATLDAAGALYAQLADVYLPDAALPALLDTLRSARIDSGEQAVACVAEAAAAHK
HHHEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
VVPTPDTSALADARTGIDRHFAQPDIGAILASLDADQDCAAVDGWIEKATHAMREQLSPL
CCCCCCCHHHHHHHHCHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHH
SMAVSLEVVERARGATMADCLRRDLDLTRSTFARGDVIEGVRALIVDKDHQPVWRFKSSA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCCHHHCCCCC
DIDRADVLAMFDSPWAPDTHPLRNLQD
CCCHHHEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]