Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 78066166

GI number: 78066166

Start: 1692373

End: 1693443

Strand: Reverse

Name: pyrD [H]

Synonym: Bcep18194_A4696

Alternate gene names: 78066166

Gene position: 1693443-1692373 (Counterclockwise)

Preceding gene: 78066167

Following gene: 78066165

Centisome position: 45.84

GC content: 68.63

Gene sequence:

>1071_bases
TTGTCATTCATTCCGGCTGTCCGCCCAATTCCCGTGTTCAGTTCCCTCTATCCGCTGGCCCGCGCATCCCTGTTCAAGAT
GGATGCGGAAGACGCTCACCACCTCACGCTGCGCGCGCTCGGCGCGGCCGGCCGTACGGGCCTTGCCTGCGCGCTGTCGG
CCCGCGTGCCCGACGCGCCGCGCACCGTGATGGGGCTCACGTTCCGCAACCCGGTCGGCCTCGCGGCCGGCCTCGACAAG
GACGGCGCGGCCATCGACGGCCTTGCGGCGCTCGGTTTCGGCTTCATCGAGGTCGGTACGGTCACGCCGCGCGCGCAGCC
CGGCAACCCGCGCCCGCGGATGTTCCGCCTGCCGCAGGCCGAAGCGCTGATCAACCGGATGGGCTTCAACAACCACGGCG
TCGACCAGTTCGTGAAGAACGTCCAGGCCGCCCGCTATCGCGGCATCCTCGGCCTGAACATCGGCAAGAACGCCGATACG
CCGATCGAGCGCGCTGCCGAGGACTACCTGTACTGCCTCGAGCGCGTGTACCCGTTCGCGAGCTACGTGACGATCAACAT
CTCGTCGCCGAATACGAAGAACCTGCGCCAGCTGCAGGGCGCGGGCGAGCTCGACGCGCTGCTCGCGGCGCTGAAGGACA
AGCAGCAGCGCCTCGCGGACCTGCACGGCAAGCTCGTGCCGCTCGCGCTGAAGATCGCGCCCGATCTCGACGACGAACAG
GTCAAGGAAATCGGCGACACGCTGCTGCGCCACAAGATCGAGGCGGTCATCGCCACCAACACGACGCTGTCGCGCGCGGC
CGTCCAGGGCCTGCCGCATGCGGACGAAGCCGGCGGCCTGTCCGGCCGCCCCGTGTTCGACGCGTCGAACGAGGTGATCC
GCAAGCTGCACGCCGAAGTCGGCAGCGAAGTGCCGATCATCGGGGTCGGCGGCATTTTCTCGGGTGAGGATGCCCGGGCC
AAGCTCGCGGCCGGCGCGGCGCTCGTGCAGCTCTATACGGGCTTCATCTATCGCGGCCCCGCGCTCGTCTCGGAATGCGT
GAAGGCCATCGCTCGCGAACGCACCGCGTAA

Upstream 100 bases:

>100_bases
CACCGTTGCCGGGCGGGCATTCCGGCTCGGGCTGACGCGCGCCGCGGGGATGACGAAGCGAAGCGCGCCCCTGCCGCCCA
ACTCCCGGTAAAATAGCGGG

Downstream 100 bases:

>100_bases
TATAGGCATAAACAAACGGTATTTAGTGGTCGATTGCGTTTTTGCTATCATCGACCCCGTTATCAGAATCAATGACCCGG
ACAGGGCAAGGAAACACACG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSFIPAVRPIPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDK
DGAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADT
PIERAAEDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSEVPIIGVGGIFSGEDARA
KLAAGAALVQLYTGFIYRGPALVSECVKAIARERTA

Sequences:

>Translated_356_residues
MSFIPAVRPIPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDK
DGAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADT
PIERAAEDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSEVPIIGVGGIFSGEDARA
KLAAGAALVQLYTGFIYRGPALVSECVKAIARERTA
>Mature_355_residues
SFIPAVRPIPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDKD
GAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTP
IERAAEDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQV
KEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSEVPIIGVGGIFSGEDARAK
LAAGAALVQLYTGFIYRGPALVSECVKAIARERTA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=44.047619047619, Blast_Score=252, Evalue=5e-67,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=56.2874251497006, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=41.7177914110429, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI281361352, Length=296, Percent_Identity=44.2567567567568, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI17137316, Length=296, Percent_Identity=44.2567567567568, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37928; Mature: 37797

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIPAVRPIPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAP
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCC
RTVMGLTFRNPVGLAAGLDKDGAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQA
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHH
EALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAAEDYLYCLERVYPFA
HHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE
SYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
EEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHH
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEV
HHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GSEVPIIGVGGIFSGEDARAKLAAGAALVQLYTGFIYRGPALVSECVKAIARERTA
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFIPAVRPIPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCC
RTVMGLTFRNPVGLAAGLDKDGAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQA
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHH
EALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAAEDYLYCLERVYPFA
HHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE
SYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
EEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHH
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEV
HHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GSEVPIIGVGGIFSGEDARAKLAAGAALVQLYTGFIYRGPALVSECVKAIARERTA
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA