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The map label for this gene is relA [H]

Identifier: 78066085

GI number: 78066085

Start: 1594724

End: 1596958

Strand: Direct

Name: relA [H]

Synonym: Bcep18194_A4614

Alternate gene names: 78066085

Gene position: 1594724-1596958 (Clockwise)

Preceding gene: 78066084

Following gene: 78066086

Centisome position: 43.17

GC content: 66.44

Gene sequence:

>2235_bases
ATGACCGAGTCCGTTTCCGCCTCCCCCGTCGCGGCACCGTCGTTCGACGACGTGCTCGCGTTCGTGCGCGAGCGGGCCGG
CGACGTGCGCCTGTCGTCGGGCGAGCTGCTCGCCGATCACTCGGCGGGCACGGCGTCGATCATGCGCACGCTGAACGTTG
ACCCGTCCGCGATGCAGGCGGCTGCGCTGTTCGTACTGACACCGCACCTGAGCGACCCCGAGCGCGAACTCACCGAGCGT
TTCGGCGACGAAGTGGCGCGGCTCGTGTCCGACGTGCGCAAGCTGTTGCGACTCGGTACCGTCAGCCTGCGTGCCGCGCA
GAATGCGGTGCCCGATGCGGGGCGCGATGCGGCGGAAGAGCGGCGTACGCAGATCGAGGCGCTGCGCAAGATGCTGCTTT
CGTTCGCGCAAGACATCCGCGTGGTGCTGATCCGGCTCGCATCCCGCTTGCAGTCGCTGCGCTACTACGCGGCGGCGAAG
ATCGACCCGCCGCCCGACGTCGCGCGTGAGACGCTCGAAATTTATGCGCCGCTCGCGAACCGTCTGGGTATCTGGCAACT
GAAATGGGAGCTCGAGGATCTCGCGTTCCGCTTCGAGGATCCGGTCACCTACAAGCGGATCGCGAAGCTGCTCGACGAGA
AGCGCATCGAGCGCGAAGCGTACGTCACGCAGGCGATCGACCGGTTGCAGCAAGAGCTGGCGGACGCGAACATCCAGGCC
GACGTGAGCGGCCGGCCGAAGCATATCTACAGCATCTGGCGCAAGATGCGCGGCAAGGAGCTCGACTTCTCCGAGCTGTA
TGACGTGCGCGCGTTTCGCGTGATCGTGCCGGACATCAAGGATTGCTACGCGGTGCTCGGCATCGTGCATCACCTGTGGC
AGCCGGTGCCGAAGGAATTCGACGACTACATCTCGCGGCCGAAGCCGAACGGCTACAAGTCGCTGCACACGGTCGTGATC
GGCGACGACGGTCGCGCGTTCGAAGTGCAGATCCGTACGCAGGAGATGCACCGTTTCGCCGAGTATGGCGTCGCTGCGCA
CTGGCGCTACAAGGAAGCCGGCGCGCGCGGCTACGGTGGCCAGTTCTCGGCAAGCGACAAGTACGACGAGAAGATCGCAT
GGCTGCGCCAGTTGCTTGCGTGGAAGGATGACGTCGAGGACGGCGCGGAAAAGTCGGGCGACAAGGCGTGGGCGCAATTG
CGCGAGACGTCGCTCGACGACGATCACATCTACGTGCTGACGCCGCAGGCGCGTGTGATCGCATTGCCGCAGGGCGCGAC
ACCGGTCGATTTCGCGTACCACCTGCACAGCGAACTTGGCCATCGCTGCCGTGGTGCGCGCGTCGACGGCGCGATGGTGC
CGCTCAATACGCCGCTCGCAAACGGCCAGACGGTCGAGATCGTCGCGGTGAAGGAGGGCGGGCCGTCGCGCGACTGGCTG
AACCTGCAGCTCGGCTATATGAAGAGCCCGCGTGCGCGTCAGAAGGTGCGTGCGTGGTTCAACTCGATCGAGCAGGAAGA
AAACGTCTCGCATGGCCGCGCGCTCGTCGAAAAGACGCTGCAACGCGAGGGCAAGACGTCGGTCAACCTGGACAATCTCG
CCGCGAAGCTCGGCTTCAAGTCGCCCGAGGAACTGTTCTCGGTCGTCGGCAAGGAAGAGTTCAGCCTGCGCAATGTCGAG
CACGCGCTGTCCGATGCGCCGCCGCCCGAGCCGGCGCCCGAGGCGCCTGCCGATTTCGAGAAGCGCAGCAGCGGCGCGAG
CGTGGCGCACGGTGCGTCGACCGGCGTGCTGGTCGTAGGCGTCGATGCGCTGCTGACCCAGCTCGCGCGCTGCTGTCGTC
CGGCGCCGCCCGATCCGATCAGCGGTTTCGTCACGCGCGGCAAGGGGATGTCGATCCACCGGACCGATTGCCCGACGTTC
CGCCGGATGGTCGAGCGCGCGCCGGAGCGCGTGCTGCAGACGACCTGGTCGGCCGATGTGCTCGGCGGGCGCGGGGTGTC
CGTCTATCCGGTCGACCTGATGATCGAGGCGAGCGACCGGCAAGGGTTGCTGCGCGACATCTCCGAAGTATTCGCGCGCG
AGAAGATGAACGTGGTGGGCGTGAAGACGCAGAGCCGCCGCAATGCGGCATTCATGCAGTTTACGGTCGAGGTATCGAAC
TCGGCGCAGGTGCAGCGTGCGTGCACGCTGCTCGGCGAGGTACAGGGCGTCGTGCGGGCGGGGCGGAAGGCGTGA

Upstream 100 bases:

>100_bases
GAAGCTTGCGGATCCGGCGCTGCTCGTCGAGATCGTGGTCGTTGCTGCCCAGCGGAGCTGAACGTAACCCGACGATGATC
GCATTCCGCCAGGCCGAGCA

Downstream 100 bases:

>100_bases
TGTGGGGTTCGAACACCGTTATTTTGCTGCGACCGCATAAAAATACTTGCCAAGCAGGTAACAGCTCCATATAATCTTAG
CTTCACTAGGCTCGTAGCTC

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MTESVSASPVAAPSFDDVLAFVRERAGDVRLSSGELLADHSAGTASIMRTLNVDPSAMQAAALFVLTPHLSDPERELTER
FGDEVARLVSDVRKLLRLGTVSLRAAQNAVPDAGRDAAEERRTQIEALRKMLLSFAQDIRVVLIRLASRLQSLRYYAAAK
IDPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIDRLQQELADANIQA
DVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVI
GDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEDGAEKSGDKAWAQL
RETSLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWL
NLQLGYMKSPRARQKVRAWFNSIEQEENVSHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPEELFSVVGKEEFSLRNVE
HALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRTDCPTF
RRMVERAPERVLQTTWSADVLGGRGVSVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSN
SAQVQRACTLLGEVQGVVRAGRKA

Sequences:

>Translated_744_residues
MTESVSASPVAAPSFDDVLAFVRERAGDVRLSSGELLADHSAGTASIMRTLNVDPSAMQAAALFVLTPHLSDPERELTER
FGDEVARLVSDVRKLLRLGTVSLRAAQNAVPDAGRDAAEERRTQIEALRKMLLSFAQDIRVVLIRLASRLQSLRYYAAAK
IDPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIDRLQQELADANIQA
DVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVI
GDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEDGAEKSGDKAWAQL
RETSLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWL
NLQLGYMKSPRARQKVRAWFNSIEQEENVSHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPEELFSVVGKEEFSLRNVE
HALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRTDCPTF
RRMVERAPERVLQTTWSADVLGGRGVSVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSN
SAQVQRACTLLGEVQGVVRAGRKA
>Mature_743_residues
TESVSASPVAAPSFDDVLAFVRERAGDVRLSSGELLADHSAGTASIMRTLNVDPSAMQAAALFVLTPHLSDPERELTERF
GDEVARLVSDVRKLLRLGTVSLRAAQNAVPDAGRDAAEERRTQIEALRKMLLSFAQDIRVVLIRLASRLQSLRYYAAAKI
DPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIDRLQQELADANIQAD
VSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIG
DDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEDGAEKSGDKAWAQLR
ETSLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWLN
LQLGYMKSPRARQKVRAWFNSIEQEENVSHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPEELFSVVGKEEFSLRNVEH
ALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRTDCPTFR
RMVERAPERVLQTTWSADVLGGRGVSVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSNS
AQVQRACTLLGEVQGVVRAGRKA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=703, Percent_Identity=40.2560455192034, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1790082, Length=728, Percent_Identity=34.2032967032967, Blast_Score=390, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82845; Mature: 82714

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVSASPVAAPSFDDVLAFVRERAGDVRLSSGELLADHSAGTASIMRTLNVDPSAMQA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCEEECCCCCHHHHHHHCCCCHHHHHH
AALFVLTPHLSDPERELTERFGDEVARLVSDVRKLLRLGTVSLRAAQNAVPDAGRDAAEE
HHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHH
RRTQIEALRKMLLSFAQDIRVVLIRLASRLQSLRYYAAAKIDPPPDVARETLEIYAPLAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIDRLQQELADANIQA
CCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
DVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEF
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHHH
DDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGG
HHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCHHEEEEHHCCCCCCCC
QFSASDKYDEKIAWLRQLLAWKDDVEDGAEKSGDKAWAQLRETSLDDDHIYVLTPQARVI
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCEEE
ALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWL
EECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCEE
NLQLGYMKSPRARQKVRAWFNSIEQEENVSHGRALVEKTLQREGKTSVNLDNLAAKLGFK
EEEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
SPEELFSVVGKEEFSLRNVEHALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVG
CHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEECCCCCCEEEEE
VDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRTDCPTFRRMVERAPERVLQTTWSADV
HHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
LGGRGVSVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSN
CCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEEECC
SAQVQRACTLLGEVQGVVRAGRKA
CHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TESVSASPVAAPSFDDVLAFVRERAGDVRLSSGELLADHSAGTASIMRTLNVDPSAMQA
CCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCEEECCCCCHHHHHHHCCCCHHHHHH
AALFVLTPHLSDPERELTERFGDEVARLVSDVRKLLRLGTVSLRAAQNAVPDAGRDAAEE
HHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHH
RRTQIEALRKMLLSFAQDIRVVLIRLASRLQSLRYYAAAKIDPPPDVARETLEIYAPLAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVTQAIDRLQQELADANIQA
CCCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
DVSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEF
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHHH
DDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGG
HHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCHHEEEEHHCCCCCCCC
QFSASDKYDEKIAWLRQLLAWKDDVEDGAEKSGDKAWAQLRETSLDDDHIYVLTPQARVI
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCEEE
ALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWL
EECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCEE
NLQLGYMKSPRARQKVRAWFNSIEQEENVSHGRALVEKTLQREGKTSVNLDNLAAKLGFK
EEEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
SPEELFSVVGKEEFSLRNVEHALSDAPPPEPAPEAPADFEKRSSGASVAHGASTGVLVVG
CHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEECCCCCCEEEEE
VDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRTDCPTFRRMVERAPERVLQTTWSADV
HHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
LGGRGVSVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSN
CCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEEECC
SAQVQRACTLLGEVQGVVRAGRKA
CHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]