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The map label for this gene is livM [H]

Identifier: 78066030

GI number: 78066030

Start: 1531956

End: 1533185

Strand: Direct

Name: livM [H]

Synonym: Bcep18194_A4559

Alternate gene names: 78066030

Gene position: 1531956-1533185 (Clockwise)

Preceding gene: 78066029

Following gene: 78066031

Centisome position: 41.47

GC content: 74.8

Gene sequence:

>1230_bases
ATGCGTAACCGTACGCTCGCCGGCGTCGCGCGCTGGTCCCTGTTCGCCGCATGCGTCGCGCTGCCCGCGTGGCTGTGGCC
GCATGGCGCGGTGCTCGGCTATCTCGCGCAGACGGCCGCGCTCGTCGTGCTCGCACTGTCGTACAACCTGCAGCTCGGCA
CGACCGGGCTGCTGTCGTTCGGGCACGCGGCGTTCGCGGGCCTCGGTGCGTTCGCGGCCGCACACTGGTTCAACCACTTT
GGCGGCCCGCTGCCGCTGTTGCCGCTCGTCGGCGGCGTGGCCGGCGCCGGTTTCGGCTTCGCCGCCGGGCTGCTCGCGAC
GCGCCGCGCGGGCACCGCGTTCGCGATGATCACGCTCGGGCTCGGCGAATGCGTCGCCGCCGCCGCGTGGAGCGTGCCCG
CCTGGTTCGGCGGGATCGGCGGTGTGCCGATCGACCGCGCGAGCGGCACACCGTGGGGCGGCTGGCATTTCGGCGCACCC
GTCCAGGCGTATGCGGTGATCGCTGCGTGGTGCCTCGCATCGGCATGGGCGATGCACGCGCTGACGCGCACGCCGCTCGC
GCGGCTCGCGAATGCCGTGCGCGACAACCCCGTGCGCGTCGCCGCGCTCGGCACCGATCCGCGCCGCGTGCGGCTCGCGA
TGGTCACCTGCGCGTCGTTCTTCGCCGGCGTCGCCGGCACACTGACGCTGATCGACGTCGAAATCGCGACGCCCGACAGC
GTATCGATGGCGCGTTCGGCGACCGTGCTGATCGCCGCGGTGATCGGCGGCACCGGCGCGTTCTTCGGGCCGGCGGCCGG
CGCGGCCGTGCTGACCGCGCTGAGCATCGTCGTCGCGGGCGTGTCGCGCGCGTGGGCGCTGTATCTCGGCGTGCTGTTCG
TCGTGATCGTCGTGGCCGCGCCGCGCGGCATCGCCGGGATCGCGCAAGCGCTCGCGCAGGCATGGCGGCGCGGCGCGCCG
GCGGCCGAACGGTGGCGCATGCTGTGCGCGGTCGGTGCGTGCGTGTTCTGGGGCGTCGCGCTGGTCTGCGCGGCCGAGCT
CGGCTATGCGTGGCGCTTCGCGCAGGACGACGGCGCGGGCTTCGCGTTCGGCGCCTGGAGCATCGACGCCGATACGCCGG
CCGGCTGGGCCGTCGCGTGCTCCGCATTCGGCATCGGCACGCTGCTGTGGGGCTGGCGCGCGCGGCTCGTGCCGGGCGGG
CAGGCCGGCAAGCGGGAGGACGGGCGATGA

Upstream 100 bases:

>100_bases
GCCGCGGTGTCGATCGCGCAGCTTGCGCCGCTGGTGCCGTACCTGCTGCTCGTCGTGGTGCTGGTCGCGCGACCGCGCGG
GCTGTTCGGCGAGCGTGCCG

Downstream 100 bases:

>100_bases
ACGGCAACGCGATCGCGCTTCACGGTGTGGTGCAGCGCTTCGGCGCGCAGACGGTGCTCGACGGCGTCGAGCTGAGCATT
GCGGCCGGCGAGCGTCATGC

Product: branched chain amino acid ABC transporter inner membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRNRTLAGVARWSLFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNHF
GGPLPLLPLVGGVAGAGFGFAAGLLATRRAGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWHFGAP
VQAYAVIAAWCLASAWAMHALTRTPLARLANAVRDNPVRVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVEIATPDS
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIVVAGVSRAWALYLGVLFVVIVVAAPRGIAGIAQALAQAWRRGAP
AAERWRMLCAVGACVFWGVALVCAAELGYAWRFAQDDGAGFAFGAWSIDADTPAGWAVACSAFGIGTLLWGWRARLVPGG
QAGKREDGR

Sequences:

>Translated_409_residues
MRNRTLAGVARWSLFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNHF
GGPLPLLPLVGGVAGAGFGFAAGLLATRRAGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWHFGAP
VQAYAVIAAWCLASAWAMHALTRTPLARLANAVRDNPVRVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVEIATPDS
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIVVAGVSRAWALYLGVLFVVIVVAAPRGIAGIAQALAQAWRRGAP
AAERWRMLCAVGACVFWGVALVCAAELGYAWRFAQDDGAGFAFGAWSIDADTPAGWAVACSAFGIGTLLWGWRARLVPGG
QAGKREDGR
>Mature_409_residues
MRNRTLAGVARWSLFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNHF
GGPLPLLPLVGGVAGAGFGFAAGLLATRRAGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWHFGAP
VQAYAVIAAWCLASAWAMHALTRTPLARLANAVRDNPVRVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVEIATPDS
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIVVAGVSRAWALYLGVLFVVIVVAAPRGIAGIAQALAQAWRRGAP
AAERWRMLCAVGACVFWGVALVCAAELGYAWRFAQDDGAGFAFGAWSIDADTPAGWAVACSAFGIGTLLWGWRARLVPGG
QAGKREDGR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=339, Percent_Identity=27.7286135693215, Blast_Score=92, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 41851; Mature: 41851

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNRTLAGVARWSLFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSF
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHH
GHAAFAGLGAFAAAHWFNHFGGPLPLLPLVGGVAGAGFGFAAGLLATRRAGTAFAMITLG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHH
LGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWHFGAPVQAYAVIAAWCLASAWAMHA
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LTRTPLARLANAVRDNPVRVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVEIATPDS
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCC
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIVVAGVSRAWALYLGVLFVVIVVAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGIAGIAQALAQAWRRGAPAAERWRMLCAVGACVFWGVALVCAAELGYAWRFAQDDGAG
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCE
FAFGAWSIDADTPAGWAVACSAFGIGTLLWGWRARLVPGGQAGKREDGR
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCC
>Mature Secondary Structure
MRNRTLAGVARWSLFAACVALPAWLWPHGAVLGYLAQTAALVVLALSYNLQLGTTGLLSF
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHH
GHAAFAGLGAFAAAHWFNHFGGPLPLLPLVGGVAGAGFGFAAGLLATRRAGTAFAMITLG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHH
LGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWHFGAPVQAYAVIAAWCLASAWAMHA
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LTRTPLARLANAVRDNPVRVAALGTDPRRVRLAMVTCASFFAGVAGTLTLIDVEIATPDS
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCC
VSMARSATVLIAAVIGGTGAFFGPAAGAAVLTALSIVVAGVSRAWALYLGVLFVVIVVAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGIAGIAQALAQAWRRGAPAAERWRMLCAVGACVFWGVALVCAAELGYAWRFAQDDGAG
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCE
FAFGAWSIDADTPAGWAVACSAFGIGTLLWGWRARLVPGGQAGKREDGR
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]