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The map label for this gene is livH [H]

Identifier: 78066029

GI number: 78066029

Start: 1531028

End: 1531963

Strand: Direct

Name: livH [H]

Synonym: Bcep18194_A4558

Alternate gene names: 78066029

Gene position: 1531028-1531963 (Clockwise)

Preceding gene: 78066028

Following gene: 78066030

Centisome position: 41.44

GC content: 72.33

Gene sequence:

>936_bases
GTGCACGCGTTCGCGCTCCAGGCCTTCAACGGCCTCAGCTACGGCTTGCTGCTGTTCATGCTGTCGGCCGGACTCACGCT
GATCTTCAGCGTGCAGGGCGTGCTCAATTTCGCGCATGCGAGCTTCTACATGCTCGGCGCCTATGTCGGCTACAGCATCG
CGGCCGGCGCGGGCTTCTGGCCCGCGCTGGTGCTCGCGCCGCTCGCGGTCGGGCTGCTCGGCGCCGGTTGCGAACGCATG
TTGCTGCGCCGCGTGCAGGCGCGCAGCCATACGAGCGAACTGCTGCTGACCTTCGGCCTCGCGTACCTGATCGGCGAGGG
CGCGAAACTCGTGTGGGGCCTCGCGCCGCTGCCGGCACCCGTGCCGGCGTTGTTCGACGGCGCGCCCGTGACCGTATTCG
GCCTCGCGCTGCCGCGCTACCGGCTGTTCATGATGGGGATGTCCACGGCGATGCTGGTCGCGCTTGGCGCGCTGCTGCGC
GCGTCGCGCATCGGGCTCGTCGTGCGCGCGGCGCTCACGCACCGTGCGGCCGTCGAGGCGCTCGGCTACGACGTGCCGCG
CGTGATGACGGCGCTGTTCGGCGCGGGCACCGCGCTCGCGGCGCTGGCCGGCGTGATCGGCGCGCCGCTCGCGGTGATCG
AACCCGCGCTGGCCGAAACCGTCGGGTCGGTCGTGTTCGCGGTCGTCGTGATCGGCGGGCTCGGCTCGCTCGGCGGCGCA
TTCGCGGCGTCGCTCGCGGTCGGCTTCGCGCAGACCTTCGCGGCCGCGAGCGACACGTCGCTGCGCGACCTCACGGAATG
GGCCGGCATCGCGCTGCCCGACAGCGTGGCCGCGGTGTCGATCGCGCAGCTTGCGCCGCTGGTGCCGTACCTGCTGCTCG
TCGTGGTGCTGGTCGCGCGACCGCGCGGGCTGTTCGGCGAGCGTGCCGATGCGTAA

Upstream 100 bases:

>100_bases
CATTTCGTGCACGTGTACGTCGATCGCGCCACGCGCCGGCCGGTGCCGCTGCCCGACGCGCTGCGCGCCGCGCTCGAGCC
GCTCGCGGCCTGACTTCGCA

Downstream 100 bases:

>100_bases
CCGTACGCTCGCCGGCGTCGCGCGCTGGTCCCTGTTCGCCGCATGCGTCGCGCTGCCCGCGTGGCTGTGGCCGCATGGCG
CGGTGCTCGGCTATCTCGCG

Product: branched chain amino acid ABC transporter inner membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MHAFALQAFNGLSYGLLLFMLSAGLTLIFSVQGVLNFAHASFYMLGAYVGYSIAAGAGFWPALVLAPLAVGLLGAGCERM
LLRRVQARSHTSELLLTFGLAYLIGEGAKLVWGLAPLPAPVPALFDGAPVTVFGLALPRYRLFMMGMSTAMLVALGALLR
ASRIGLVVRAALTHRAAVEALGYDVPRVMTALFGAGTALAALAGVIGAPLAVIEPALAETVGSVVFAVVVIGGLGSLGGA
FAASLAVGFAQTFAAASDTSLRDLTEWAGIALPDSVAAVSIAQLAPLVPYLLLVVVLVARPRGLFGERADA

Sequences:

>Translated_311_residues
MHAFALQAFNGLSYGLLLFMLSAGLTLIFSVQGVLNFAHASFYMLGAYVGYSIAAGAGFWPALVLAPLAVGLLGAGCERM
LLRRVQARSHTSELLLTFGLAYLIGEGAKLVWGLAPLPAPVPALFDGAPVTVFGLALPRYRLFMMGMSTAMLVALGALLR
ASRIGLVVRAALTHRAAVEALGYDVPRVMTALFGAGTALAALAGVIGAPLAVIEPALAETVGSVVFAVVVIGGLGSLGGA
FAASLAVGFAQTFAAASDTSLRDLTEWAGIALPDSVAAVSIAQLAPLVPYLLLVVVLVARPRGLFGERADA
>Mature_311_residues
MHAFALQAFNGLSYGLLLFMLSAGLTLIFSVQGVLNFAHASFYMLGAYVGYSIAAGAGFWPALVLAPLAVGLLGAGCERM
LLRRVQARSHTSELLLTFGLAYLIGEGAKLVWGLAPLPAPVPALFDGAPVTVFGLALPRYRLFMMGMSTAMLVALGALLR
ASRIGLVVRAALTHRAAVEALGYDVPRVMTALFGAGTALAALAGVIGAPLAVIEPALAETVGSVVFAVVVIGGLGSLGGA
FAASLAVGFAQTFAAASDTSLRDLTEWAGIALPDSVAAVSIAQLAPLVPYLLLVVVLVARPRGLFGERADA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=324, Percent_Identity=25.3086419753086, Blast_Score=78, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31835; Mature: 31835

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAFALQAFNGLSYGLLLFMLSAGLTLIFSVQGVLNFAHASFYMLGAYVGYSIAAGAGFW
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
PALVLAPLAVGLLGAGCERMLLRRVQARSHTSELLLTFGLAYLIGEGAKLVWGLAPLPAP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCC
VPALFDGAPVTVFGLALPRYRLFMMGMSTAMLVALGALLRASRIGLVVRAALTHRAAVEA
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYDVPRVMTALFGAGTALAALAGVIGAPLAVIEPALAETVGSVVFAVVVIGGLGSLGGA
HCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
FAASLAVGFAQTFAAASDTSLRDLTEWAGIALPDSVAAVSIAQLAPLVPYLLLVVVLVAR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGLFGERADA
CCCCCCCCCCC
>Mature Secondary Structure
MHAFALQAFNGLSYGLLLFMLSAGLTLIFSVQGVLNFAHASFYMLGAYVGYSIAAGAGFW
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
PALVLAPLAVGLLGAGCERMLLRRVQARSHTSELLLTFGLAYLIGEGAKLVWGLAPLPAP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCC
VPALFDGAPVTVFGLALPRYRLFMMGMSTAMLVALGALLRASRIGLVVRAALTHRAAVEA
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYDVPRVMTALFGAGTALAALAGVIGAPLAVIEPALAETVGSVVFAVVVIGGLGSLGGA
HCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
FAASLAVGFAQTFAAASDTSLRDLTEWAGIALPDSVAAVSIAQLAPLVPYLLLVVVLVAR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGLFGERADA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]