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The map label for this gene is yjcE [H]

Identifier: 78066005

GI number: 78066005

Start: 1505720

End: 1507300

Strand: Reverse

Name: yjcE [H]

Synonym: Bcep18194_A4534

Alternate gene names: 78066005

Gene position: 1507300-1505720 (Counterclockwise)

Preceding gene: 78066006

Following gene: 78066004

Centisome position: 40.8

GC content: 70.71

Gene sequence:

>1581_bases
ATGACCAACGTCGAACTGTTTCATTACCTGCTGCTGTTGATCTGCGGTGCGGGCGCGCTCACGTGGCTCGCCGAGCGGAT
TTCGATTCCACCGGCCGTCGTGCTGCTGCTCGGCGGCTGCGTGGTCGCGGTTGCCGGCAAGCGCGTGCCCGACATGGACC
CGGCGCTGCTGCTCGCGGCCGTGCTGCCGCCGCTGCTGATGTCGAGCGGGTTCTACACCGCGTGGAAGGAATTCCGGCAG
GAACTTGCATCGATCGCGTCGCTCGCGCTCGGCGCGGTGGTGTTCACCACGGTCGCGGTCGCGCTCGTCGTGCATGCGGT
GAACCCAACGCTGCCGTGGGCCGCCTGCTTCACGCTCGGCGCGATCGTGTCGCCGCCGGACGCAGTCGCCGCGAAAGCGA
TCCTGCAGCGCCACCCGCTGCCCTCACGGCTCGTCGCGGTGCTCGAAGGCGAAAGCCTCGTCAACGATGCGTCGGGCCTG
CTGCTGTACCAGATGGCCGTGTCGGCCGCGCTCGCCGTGTCGATCACGGCCGCGAGCGCCACCGGGCTGTTCTTCTCGCT
CACGCTGATCGGCATCGCGGTCGGCCTCGCGTGCGGCCATGCGATGAGCTGGGTGCTGCCGCGCCTGCGCGACCCGATGC
TCGGCATCGTCGTGACCTTCGCGATGGCGTGGGGCAGCTACGGGATCGCGGAAGCCGTCGACGGCTCGGGCGTGCTGTCG
GTCGTCACCTGTGGCCTCGTGCTCGGCGTGCGCCAGCATCGCGTGTTCGACGCCGACATGCGGATCAAGGCGAAGGCGAC
GTGGGAAGCGATCGTGTTCGTGCTCGACGCGCTCGTGTTCATCCTGATCGGCCTCGCGCTGCACGCGATCCTCGCACGCG
TGAACCACGAAGGCGCGGTGCTGATGGCCGGCCTGCGCGTCGCGCTGCCCGCCACCGCCGCCGCGATCGCCGCGCGCATC
GTCTGGGTGTTCGTCGCGATGTGGCTGCCGGGCCGCCTGCGCGCGCCGCGCGCCGGCCACGCACCGTGGTCGTGGCGCGA
AGCCGTCGTGCTCGGCTGGTCGGGCATGCGCGGCGTCGTGAGCCTCGCGGCGGCGATCGCGCTGCCCGCCAACTTCCCCG
GCCGCGACCTGATCCTGTTCAGCACGTTCCTGCTGATCATCGCCACGCTCGTCGTGCAGGGCGGCACGCTCGCGCCGCTG
ATCCGCGTGCTGAAGCTGCACCCGGCCGCGCGGCACACGATGTCCGAGCATGCGGTGCGCGCGCATGCGTTCGGCGCGGC
GCTCGCCGAACTCGACGCGCTCGAACAGCGCGGCTCGACCCTCGAGCGGCCGTCGCTCGACCGGCTGCTCGCCGAATACC
GGAACCGCGTCACCTTCAACGACCGCGCGCATCGCCAGGGCGCCGAACCGGCCAAGGTGCGCTCGCGCATGCTGCGCGTC
GAACTCGAGCTCGTCGGCGTGTCGCGCCGCGCGCTGCTCGACCTGCATCGCGACGGCAAGGTCGACGACGCCGTGCTGCA
CCGGATCGAATCGGAGCTCGATTTCGAGGAACTGCGGCTGCAGCGGCTGCTCGAACCGTAA

Upstream 100 bases:

>100_bases
CGCGATGCACAATGCAGCCAGCACATGTTCGGCGCGCTGCCCGGCGGCACGCCGAACGACCGCAAGCCGTCGTGACGCAA
CCGTTCGCCGCCGGCCACGC

Downstream 100 bases:

>100_bases
CGCCCGGCCACGCCGCCGCCCCCCTTCTTTACATGGAACTGCAATGAGCGAACTGTCCGTCGAAGCGAGCATCGGCTCCG
TCGATTACCTCGTCCACTTC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTNVELFHYLLLLICGAGALTWLAERISIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKEFRQ
ELASIASLALGAVVFTTVAVALVVHAVNPTLPWAACFTLGAIVSPPDAVAAKAILQRHPLPSRLVAVLEGESLVNDASGL
LLYQMAVSAALAVSITAASATGLFFSLTLIGIAVGLACGHAMSWVLPRLRDPMLGIVVTFAMAWGSYGIAEAVDGSGVLS
VVTCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILARVNHEGAVLMAGLRVALPATAAAIAARI
VWVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVVSLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPL
IRVLKLHPAARHTMSEHAVRAHAFGAALAELDALEQRGSTLERPSLDRLLAEYRNRVTFNDRAHRQGAEPAKVRSRMLRV
ELELVGVSRRALLDLHRDGKVDDAVLHRIESELDFEELRLQRLLEP

Sequences:

>Translated_526_residues
MTNVELFHYLLLLICGAGALTWLAERISIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKEFRQ
ELASIASLALGAVVFTTVAVALVVHAVNPTLPWAACFTLGAIVSPPDAVAAKAILQRHPLPSRLVAVLEGESLVNDASGL
LLYQMAVSAALAVSITAASATGLFFSLTLIGIAVGLACGHAMSWVLPRLRDPMLGIVVTFAMAWGSYGIAEAVDGSGVLS
VVTCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILARVNHEGAVLMAGLRVALPATAAAIAARI
VWVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVVSLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPL
IRVLKLHPAARHTMSEHAVRAHAFGAALAELDALEQRGSTLERPSLDRLLAEYRNRVTFNDRAHRQGAEPAKVRSRMLRV
ELELVGVSRRALLDLHRDGKVDDAVLHRIESELDFEELRLQRLLEP
>Mature_525_residues
TNVELFHYLLLLICGAGALTWLAERISIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKEFRQE
LASIASLALGAVVFTTVAVALVVHAVNPTLPWAACFTLGAIVSPPDAVAAKAILQRHPLPSRLVAVLEGESLVNDASGLL
LYQMAVSAALAVSITAASATGLFFSLTLIGIAVGLACGHAMSWVLPRLRDPMLGIVVTFAMAWGSYGIAEAVDGSGVLSV
VTCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILARVNHEGAVLMAGLRVALPATAAAIAARIV
WVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVVSLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPLI
RVLKLHPAARHTMSEHAVRAHAFGAALAELDALEQRGSTLERPSLDRLLAEYRNRVTFNDRAHRQGAEPAKVRSRMLRVE
LELVGVSRRALLDLHRDGKVDDAVLHRIESELDFEELRLQRLLEP

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI27734935, Length=394, Percent_Identity=24.8730964467005, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI14211919, Length=396, Percent_Identity=23.4848484848485, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI148727259, Length=394, Percent_Identity=22.5888324873096, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI15529998, Length=410, Percent_Identity=21.9512195121951, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI110227626, Length=379, Percent_Identity=23.7467018469657, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI294997330, Length=379, Percent_Identity=24.0105540897098, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI5454070, Length=375, Percent_Identity=23.7333333333333, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI41872703, Length=478, Percent_Identity=22.3849372384937, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4759144, Length=444, Percent_Identity=23.8738738738739, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI194239733, Length=456, Percent_Identity=21.7105263157895, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI27777632, Length=391, Percent_Identity=22.5063938618926, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790501, Length=497, Percent_Identity=28.9738430583501, Blast_Score=158, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI71980847, Length=462, Percent_Identity=22.2943722943723, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71993590, Length=379, Percent_Identity=23.2189973614776, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71993582, Length=379, Percent_Identity=23.2189973614776, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25150332, Length=442, Percent_Identity=20.1357466063348, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71999819, Length=498, Percent_Identity=19.8795180722892, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71999821, Length=508, Percent_Identity=20.4724409448819, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71999817, Length=498, Percent_Identity=19.8795180722892, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25147678, Length=439, Percent_Identity=22.7790432801822, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71990932, Length=386, Percent_Identity=21.5025906735751, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71990924, Length=445, Percent_Identity=20.6741573033708, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987559, Length=421, Percent_Identity=21.1401425178147, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987537, Length=421, Percent_Identity=21.8527315914489, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987535, Length=421, Percent_Identity=21.8527315914489, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987545, Length=421, Percent_Identity=21.1401425178147, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=368, Percent_Identity=19.2934782608696, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992101, Length=368, Percent_Identity=19.2934782608696, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=455, Percent_Identity=20.2197802197802, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI281364513, Length=373, Percent_Identity=25.201072386059, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI221473212, Length=373, Percent_Identity=25.201072386059, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI221473222, Length=373, Percent_Identity=25.201072386059, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI221473215, Length=373, Percent_Identity=25.201072386059, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360447, Length=381, Percent_Identity=23.8845144356955, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221510734, Length=386, Percent_Identity=22.7979274611399, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221510738, Length=386, Percent_Identity=22.7979274611399, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221510732, Length=390, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510736, Length=390, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510740, Length=385, Percent_Identity=23.1168831168831, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585580, Length=385, Percent_Identity=23.1168831168831, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585578, Length=385, Percent_Identity=23.1168831168831, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56277; Mature: 56146

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TNVELFHYLLLLICGAGALTWLAERISIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAA
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
VLPPLLMSSGFYTAWKEFRQELASIASLALGAVVFTTVAVALVVHAVNPTLPWAACFTLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AIVSPPDAVAAKAILQRHPLPSRLVAVLEGESLVNDASGLLLYQMAVSAALAVSITAASA
CCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLFFSLTLIGIAVGLACGHAMSWVLPRLRDPMLGIVVTFAMAWGSYGIAEAVDGSGVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHH
VVTCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILARVNHEGAV
HHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LMAGLRVALPATAAAIAARIVWVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVV
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHH
SLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPLIRVLKLHPAARHTMSEHAVR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHH
AHAFGAALAELDALEQRGSTLERPSLDRLLAEYRNRVTFNDRAHRQGAEPAKVRSRMLRV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHH
ELELVGVSRRALLDLHRDGKVDDAVLHRIESELDFEELRLQRLLEP
HHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]