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The map label for this gene is folP-A [H]

Identifier: 78065911

GI number: 78065911

Start: 1399533

End: 1400432

Strand: Direct

Name: folP-A [H]

Synonym: Bcep18194_A4440

Alternate gene names: 78065911

Gene position: 1399533-1400432 (Clockwise)

Preceding gene: 78065910

Following gene: 78065912

Centisome position: 37.89

GC content: 68.56

Gene sequence:

>900_bases
TTGCTCGTGTCCGATCCTGCTGTTTCCCCATTCATCCCCGCGCCACTCCAGTGCGGCCGCTTCGAACTGACGTTCGAACG
CCCGCTGGTGATGGGCATCCTCAACGCCACGCCTGATTCGTTCTCCGACGGCGGCCGCTTCCTCGCGCGCGACGATGCGC
TGCGCCAGGCCGAGCGAATGATCGCCGAAGGCGTCGACCTTCTCGATATCGGCGGCGAATCGACGCGCCCGGGCGCACCG
CCCGTGCCGCTCGACGAGGAACTCGCACGCGTGATCCCGCTCGTCGAAGCGCTGCGGCCGCTGAACGTGCCGTTGTCGAT
CGATACGTACAAGCCGGCCGTGATGCGCGCGGCGCTGGCCGCAGGCGCCGACCTGATCAACGACATCTGGGGGTTCCGCC
AGCCGGGCGCGATCGATGCGGTGCGTGACGGTAATTGCGGGCTATGTGCGATGCACATGCTGGGTGAGCCACAAACGATG
CAGGTCGGCGAACCCGATTACGGCGACGTCGTGACCGACGTGCGCGATTTTCTCGCCGAGCGCGCGCAGGCGCTGCGCGA
TGCGGGGATTGCGCCGGAGCGGATCTGTGTCGATCCGGGCTTCGGATTCGGCAAGGCGGTCATCGACGACAACTACGCGC
TGCTGGCCGCGTTGCCGGACACGGCACCCGCGCGGACCGACGGGCGCGCGTATCCGATCCTCGCGGGCATGTCGCGCAAG
TCGATGCTCGGCGCGGTGATCGGCGGCAAGCCGCCGATGGAGCGCGTCGCGGCGAGCGTGGCAGCCGCAGTGTGTGCGGT
CGAGCGTGGGGCGGCGATCGTGCGCGTGCACGACGTCGCGGCGACGGTCGACGCGCTGAAAATCTGGAATGCCGTGCGCG
AAGCCGCGCGGCAACGATAA

Upstream 100 bases:

>100_bases
GCCTGCTTCGCCGGCGGCGTAATCTCCGCTTTAGCGCTTTAGCGCCGTTCACGGGCTGGTGTGGCTTCACACCGGCCCGT
TTTGCATTCATTCACGCCAG

Downstream 100 bases:

>100_bases
GTCAGAAGACGAAGGAGGAAGATTCGCTATGGGACGTCGATATTTCGGCACGGACGGTATTCGCGGCACGGTGGGCGAGG
GGCCCATCACACCGGATTTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLVSDPAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIAEGVDLLDIGGESTRPGAP
PVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGNCGLCAMHMLGEPQTM
QVGEPDYGDVVTDVRDFLAERAQALRDAGIAPERICVDPGFGFGKAVIDDNYALLAALPDTAPARTDGRAYPILAGMSRK
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKIWNAVREAARQR

Sequences:

>Translated_299_residues
MLVSDPAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIAEGVDLLDIGGESTRPGAP
PVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGNCGLCAMHMLGEPQTM
QVGEPDYGDVVTDVRDFLAERAQALRDAGIAPERICVDPGFGFGKAVIDDNYALLAALPDTAPARTDGRAYPILAGMSRK
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKIWNAVREAARQR
>Mature_299_residues
MLVSDPAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIAEGVDLLDIGGESTRPGAP
PVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGNCGLCAMHMLGEPQTM
QVGEPDYGDVVTDVRDFLAERAQALRDAGIAPERICVDPGFGFGKAVIDDNYALLAALPDTAPARTDGRAYPILAGMSRK
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKIWNAVREAARQR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=278, Percent_Identity=46.0431654676259, Blast_Score=235, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=29.320987654321, Blast_Score=115, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31703; Mature: 31703

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSDPAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERM
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHCCCCCCCCCCCEEEHHHHHHHHHHH
IAEGVDLLDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALA
HHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
AGADLINDIWGFRQPGAIDAVRDGNCGLCAMHMLGEPQTMQVGEPDYGDVVTDVRDFLAE
HHHHHHHHHHCCCCCCCCCCEECCCCCEEEHHHCCCCCEEECCCCCCHHHHHHHHHHHHH
RAQALRDAGIAPERICVDPGFGFGKAVIDDNYALLAALPDTAPARTDGRAYPILAGMSRK
HHHHHHHCCCCCCEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCEEEECCCHH
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKIWNAVREAARQR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLVSDPAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERM
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHCCCCCCCCCCCEEEHHHHHHHHHHH
IAEGVDLLDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALA
HHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
AGADLINDIWGFRQPGAIDAVRDGNCGLCAMHMLGEPQTMQVGEPDYGDVVTDVRDFLAE
HHHHHHHHHHCCCCCCCCCCEECCCCCEEEHHHCCCCCEEECCCCCCHHHHHHHHHHHHH
RAQALRDAGIAPERICVDPGFGFGKAVIDDNYALLAALPDTAPARTDGRAYPILAGMSRK
HHHHHHHCCCCCCEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCEEEECCCHH
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKIWNAVREAARQR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]