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The map label for this gene is hbd [H]

Identifier: 78065878

GI number: 78065878

Start: 1366972

End: 1367889

Strand: Direct

Name: hbd [H]

Synonym: Bcep18194_A4407

Alternate gene names: 78065878

Gene position: 1366972-1367889 (Clockwise)

Preceding gene: 78065875

Following gene: 78065881

Centisome position: 37.0

GC content: 67.54

Gene sequence:

>918_bases
ATGGACATTCGACGCATCGCGATCGTCGGCGCCGGCGTGATCGGCGCGAGCTGGGCCGCTTTCTATCTGACGCAGGGCTT
CGACGTCGTCGCGACCGATCCGGCGCCGCAAGCCGACACGCGGCTGCGCGAATCGCTGGCCGCGTTTCTCGGCGAGCGGG
CCGCCGAACTTTCGGCGCGGCTGTCGTTCGACGCCGATCTCGTGCGTGCGCTCGACGGTGTCGACTTCGTGCAGGAAAAC
GGCCCGGAGCGGCTCGACCTGAAGCGCGCGCTGTACCGGCAGATGGACGACGTGCTGCCCGCGCACGTGCCGATCGCGTC
GAGTTCGTCGGGCCTGAAAATGTCGGACATCCAGACCGCATGCGACAAGCATCCGGAACGCTGCCTGATTGCGCATCCGT
TCAATCCGCCGCACCTGATTCCGCTCGTCGAGCTGGTCGGCGGCGACGCCACCAGCCAGGACGTGACCGCGCGCGTGAAG
GATTTCTACGATGCGCTCGGCAAGCAGACGATCGTCCTCAACAAGGAGATGACCGGCCACGTCGCGAACCGGCTCGCGGC
CGCGCTGTTCCGCGAGGTGTATCACCTCGTCGGCGAAGGTGTCGTGAGCGTCGCCGATGCGGACAAGGCTGTCGCGTGGG
GGCCCGGTCTGCGCTGGGGGCTGATGGGGCAGTGCCTGACCTATCACCTCGGCGGCGGCACGGGCGGGATCGCGCACTTT
CTCGAACACCTGTCGGGGCCGATCACGAGTTGGTGGGACGACCTCGGCACGCCTTCGTTCGATCCGGACGTCGATCGCAA
GCTGAACGACGAATTGCGCGCGATCCAGGGCGAGCGCTCGATGCAGGAACTGGCGGCCGAACGCGACCGCTTGCTCGTCG
AGCTGATCGACGCGCGGCGCCGCAGCTTCCTGCCGTGA

Upstream 100 bases:

>100_bases
CATTTCAAGAGGGCATCTGCAATCTGCGTCAATACATGCCCGTGCGATTCGATGCGACAATCGCCGCGATCTATCTGCAG
ACCAACGACACGGGACAATC

Downstream 100 bases:

>100_bases
CCGCGCCGCGGCGTCGCGTCCGGGCCGCGGCCGGCTACTGCTGCGCGGCGGTTTGCGCTGCCTGCGGCGTCTGCGCGAGC
CAGGCGGGGCTCGCGGCCTG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQADTRLRESLAAFLGERAAELSARLSFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTACDKHPERCLIAHPFNPPHLIPLVELVGGDATSQDVTARVK
DFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGTGGIAHF
LEHLSGPITSWWDDLGTPSFDPDVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARRRSFLP

Sequences:

>Translated_305_residues
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQADTRLRESLAAFLGERAAELSARLSFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTACDKHPERCLIAHPFNPPHLIPLVELVGGDATSQDVTARVK
DFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGTGGIAHF
LEHLSGPITSWWDDLGTPSFDPDVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARRRSFLP
>Mature_305_residues
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQADTRLRESLAAFLGERAAELSARLSFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTACDKHPERCLIAHPFNPPHLIPLVELVGGDATSQDVTARVK
DFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGTGGIAHF
LEHLSGPITSWWDDLGTPSFDPDVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARRRSFLP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=290, Percent_Identity=32.7586206896552, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI20127408, Length=210, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI296179429, Length=233, Percent_Identity=26.6094420600858, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI296179427, Length=226, Percent_Identity=24.3362831858407, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1787661, Length=243, Percent_Identity=27.5720164609054, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790281, Length=130, Percent_Identity=30, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=249, Percent_Identity=32.5301204819277, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=249, Percent_Identity=32.5301204819277, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17553560, Length=229, Percent_Identity=24.8908296943231, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=211, Percent_Identity=27.4881516587678, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=211, Percent_Identity=27.4881516587678, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=211, Percent_Identity=27.4881516587678, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17549919, Length=233, Percent_Identity=24.8927038626609, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=211, Percent_Identity=27.0142180094787, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129993, Length=315, Percent_Identity=32.0634920634921, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45549573, Length=303, Percent_Identity=31.023102310231, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33288; Mature: 33288

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQADTRLRESLAAFLGERAAELSAR
CCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSFDADLVRALDGVDFVQENGPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTA
HCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CDKHPERCLIAHPFNPPHLIPLVELVGGDATSQDVTARVKDFYDALGKQTIVLNKEMTGH
HHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGTGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCHHHHHHHHHHCCCCCCCHHHHH
LEHLSGPITSWWDDLGTPSFDPDVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARR
HHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC
>Mature Secondary Structure
MDIRRIAIVGAGVIGASWAAFYLTQGFDVVATDPAPQADTRLRESLAAFLGERAAELSAR
CCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSFDADLVRALDGVDFVQENGPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTA
HCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CDKHPERCLIAHPFNPPHLIPLVELVGGDATSQDVTARVKDFYDALGKQTIVLNKEMTGH
HHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGTGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCHHHHHHHHHHCCCCCCCHHHHH
LEHLSGPITSWWDDLGTPSFDPDVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARR
HHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]