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The map label for this gene is yahK [C]

Identifier: 78065830

GI number: 78065830

Start: 1313616

End: 1314647

Strand: Direct

Name: yahK [C]

Synonym: Bcep18194_A4359

Alternate gene names: 78065830

Gene position: 1313616-1314647 (Clockwise)

Preceding gene: 78065828

Following gene: 78065831

Centisome position: 35.56

GC content: 68.51

Gene sequence:

>1032_bases
ATGAAGATGAAGGCGATCGTGATGACCGGGGCCAATCGGCCCTGGGAAGTGCAGGAAGTGGCGGTACCGGTAGCCGGGCC
GGGGCAGGTGCTGGTGAAGGTGCACGCGTCCGGGATGTGCTACACGGACGTCTGGGCCACGCAGGGGTTCGGTGGCGACA
TTTACCCGCAGACACCCGGCCACGAGGTGGTCGGCGAAATCGTCGAAGTGGGCGCGGGCGTGCATGCGCGCCGGGTGGGC
GACCGGATCGGCACGACGTGGGTGCAGTCCGCGTGCGGGCGCTGCCCGTACTGTCGCGAGCATCGTCCGCTGTCCGGCCA
GACGGCCGTGAATTGCGATGCGCCGCGGACCACCGGGTTCGCGTCGCAAGGCGGGCACGCGGAGTACATTGCCGTCGCGG
CCGAGGGCACGGTGCTGCTGCCCGATGCACTGGCCTATGTCGATGCCGCGCCGATGATGTGCGCGGGCTACACGACGTGG
AGCGGCTTGCGCGACGCGGCGCCGCAACCGCACGAGAAGGTCGCCGTGCTCGGCATCGGCGGACTGGGGCACGTGGCGCT
GCAACTGTCCCGCGCGTGCGGCTTCGAAACCATCGCGATCACGCATTCGGCCGACAAGCGCGACCTCGCCATCGGGCTGG
GCGCGGACCGGGTCGTCGAAAACGGCGCGGCGCTGCGCGACCTGGGCGGCGCGGATGTCCTGCTGGTCACGACCAACGAG
TTCAGTACTGCAGAGGAGGCCATGACGGGCGTGCGGGTCGACGGCCGGGTGATCCTCTGCGGGCTCGACTTCAGCAAGCC
GTTCTCGATCGCGTCGCAGCGCAAGCCGTTCCACATGATGCGCCAGCAGGTCATCGGCTCCACGCATGGCGGCTTGCGCT
ACCTGAGCGAAGTGCTGGACCTCGCCGCCAAAGGCAAGGTCAAACCGATCGTCGAGACGTTCTCGCTGGACCAGGCGACT
GAAGCCTATGACCGCCTCGCGTCCGGGAAGATGCGCTTTCGCGGCGTATTCACGCCCGCGCAGAGCCACTGA

Upstream 100 bases:

>100_bases
GATGAGCAGAGTTCATCTTCACGTAAAGATTGGCGAGATTGTCATGATAATGCGCCTTTTCTAGACTAGGCCCTGCGTAC
GGTTGAACAAGGAGCAGGCA

Downstream 100 bases:

>100_bases
CGCTCAAAGGTGCCCGGGGGAGGCGGGGACGCCTCTCCCGGCAAGCGCGCGTGGCCGACTCGCCGCGCGCCGCATCCGCA
TCCGCCTCCGCACGGTGATC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKMKAIVMTGANRPWEVQEVAVPVAGPGQVLVKVHASGMCYTDVWATQGFGGDIYPQTPGHEVVGEIVEVGAGVHARRVG
DRIGTTWVQSACGRCPYCREHRPLSGQTAVNCDAPRTTGFASQGGHAEYIAVAAEGTVLLPDALAYVDAAPMMCAGYTTW
SGLRDAAPQPHEKVAVLGIGGLGHVALQLSRACGFETIAITHSADKRDLAIGLGADRVVENGAALRDLGGADVLLVTTNE
FSTAEEAMTGVRVDGRVILCGLDFSKPFSIASQRKPFHMMRQQVIGSTHGGLRYLSEVLDLAAKGKVKPIVETFSLDQAT
EAYDRLASGKMRFRGVFTPAQSH

Sequences:

>Translated_343_residues
MKMKAIVMTGANRPWEVQEVAVPVAGPGQVLVKVHASGMCYTDVWATQGFGGDIYPQTPGHEVVGEIVEVGAGVHARRVG
DRIGTTWVQSACGRCPYCREHRPLSGQTAVNCDAPRTTGFASQGGHAEYIAVAAEGTVLLPDALAYVDAAPMMCAGYTTW
SGLRDAAPQPHEKVAVLGIGGLGHVALQLSRACGFETIAITHSADKRDLAIGLGADRVVENGAALRDLGGADVLLVTTNE
FSTAEEAMTGVRVDGRVILCGLDFSKPFSIASQRKPFHMMRQQVIGSTHGGLRYLSEVLDLAAKGKVKPIVETFSLDQAT
EAYDRLASGKMRFRGVFTPAQSH
>Mature_343_residues
MKMKAIVMTGANRPWEVQEVAVPVAGPGQVLVKVHASGMCYTDVWATQGFGGDIYPQTPGHEVVGEIVEVGAGVHARRVG
DRIGTTWVQSACGRCPYCREHRPLSGQTAVNCDAPRTTGFASQGGHAEYIAVAAEGTVLLPDALAYVDAAPMMCAGYTTW
SGLRDAAPQPHEKVAVLGIGGLGHVALQLSRACGFETIAITHSADKRDLAIGLGADRVVENGAALRDLGGADVLLVTTNE
FSTAEEAMTGVRVDGRVILCGLDFSKPFSIASQRKPFHMMRQQVIGSTHGGLRYLSEVLDLAAKGKVKPIVETFSLDQAT
EAYDRLASGKMRFRGVFTPAQSH

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=238, Percent_Identity=26.0504201680672, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI262073058, Length=238, Percent_Identity=26.0504201680672, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4501933, Length=374, Percent_Identity=25.1336898395722, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=23.5616438356164, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI156523966, Length=365, Percent_Identity=23.5616438356164, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=25.1336898395722, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI71565154, Length=365, Percent_Identity=22.7397260273973, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI4501929, Length=240, Percent_Identity=28.3333333333333, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=31.8051575931232, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=32.1766561514196, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082125, Length=354, Percent_Identity=30.225988700565, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082401, Length=319, Percent_Identity=29.153605015674, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787863, Length=333, Percent_Identity=27.027027027027, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI226510992, Length=347, Percent_Identity=26.5129682997118, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=27.7620396600567, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=28.9893617021277, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788073, Length=260, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790045, Length=342, Percent_Identity=26.0233918128655, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788407, Length=245, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=28.5294117647059, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=27.6353276353276, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=28.1976744186047, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=341, Percent_Identity=28.4457478005865, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=222, Percent_Identity=30.1801801801802, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=355, Percent_Identity=27.0422535211268, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=349, Percent_Identity=28.9398280802292, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323980, Length=322, Percent_Identity=28.8819875776398, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=355, Percent_Identity=26.1971830985915, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=26.7857142857143, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319949, Length=322, Percent_Identity=27.3291925465839, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=377, Percent_Identity=26.2599469496021, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=24.1847826086957, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36373; Mature: 36373

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKAIVMTGANRPWEVQEVAVPVAGPGQVLVKVHASGMCYTDVWATQGFGGDIYPQTPG
CCEEEEEEECCCCCCEEHEEEEECCCCCEEEEEEECCCEEEEHHHHCCCCCCCCCCCCCC
HEVVGEIVEVGAGVHARRVGDRIGTTWVQSACGRCPYCREHRPLSGQTAVNCDAPRTTGF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCC
ASQGGHAEYIAVAAEGTVLLPDALAYVDAAPMMCAGYTTWSGLRDAAPQPHEKVAVLGIG
CCCCCCEEEEEEEECCCEECCHHHHHHCCCCHHEECCCHHCCHHHCCCCCCCCEEEEEEC
GLGHVALQLSRACGFETIAITHSADKRDLAIGLGADRVVENGAALRDLGGADVLLVTTNE
CHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCHHHHHHCCCHHHCCCCCCEEEEECCC
FSTAEEAMTGVRVDGRVILCGLDFSKPFSIASQRKPFHMMRQQVIGSTHGGLRYLSEVLD
CCCHHHHHHCEEECCEEEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHH
LAAKGKVKPIVETFSLDQATEAYDRLASGKMRFRGVFTPAQSH
HHHCCCCCHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKMKAIVMTGANRPWEVQEVAVPVAGPGQVLVKVHASGMCYTDVWATQGFGGDIYPQTPG
CCEEEEEEECCCCCCEEHEEEEECCCCCEEEEEEECCCEEEEHHHHCCCCCCCCCCCCCC
HEVVGEIVEVGAGVHARRVGDRIGTTWVQSACGRCPYCREHRPLSGQTAVNCDAPRTTGF
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCC
ASQGGHAEYIAVAAEGTVLLPDALAYVDAAPMMCAGYTTWSGLRDAAPQPHEKVAVLGIG
CCCCCCEEEEEEEECCCEECCHHHHHHCCCCHHEECCCHHCCHHHCCCCCCCCEEEEEEC
GLGHVALQLSRACGFETIAITHSADKRDLAIGLGADRVVENGAALRDLGGADVLLVTTNE
CHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCHHHHHHCCCHHHCCCCCCEEEEECCC
FSTAEEAMTGVRVDGRVILCGLDFSKPFSIASQRKPFHMMRQQVIGSTHGGLRYLSEVLD
CCCHHHHHHCEEECCEEEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHH
LAAKGKVKPIVETFSLDQATEAYDRLASGKMRFRGVFTPAQSH
HHHCCCCCHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]