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The map label for this gene is envZ [H]

Identifier: 78065819

GI number: 78065819

Start: 1302288

End: 1303280

Strand: Direct

Name: envZ [H]

Synonym: Bcep18194_A4348

Alternate gene names: 78065819

Gene position: 1302288-1303280 (Clockwise)

Preceding gene: 78065808

Following gene: 78065820

Centisome position: 35.25

GC content: 62.84

Gene sequence:

>993_bases
ATGCACAAACCCCGCTTCGATTCGGCTTTCTATCGCCTGTTCTTCGTGATGATCTCGATCATCCTCGTGATGCAGATCAG
TGCCGGCCTGCTGCTCTACAAGCTCTACAGTTCCGAGCCCTTCAAACCGCCGCCCGGGATGAGCGCAGCGTTGCAGTGGG
CCGCCGCGGTGATGATCCAGGTGATGCCGGCACTGATCTCGTCCTGGATCGGCGCGCGCATGCTGGCCGCCCCGTTCCGC
ACGCTGGCCGTCGGGGCCGCTGAACTGTCGAGGAATATCGATGCGCCGCCCATCAAGGAAATCGGCCCTGTCGAGGCGCG
TCAGGCCGCCAGCGTGTTCAACACGATGCAGGCGTCGCTGCGGCGGCAAATGAGTGAGCGCAACCGTTTTCTCGCCGCCG
TATCGCACGATCTGCGCACGCCGCTGACGCGCATGAAGCTGCGCCTTCGATCCGCTCAGGATGTCGAATTGAGTGAACGG
CTCAGAGACGATATCGACGAGATGACGCAGCTTCTGGAGGCCACGCTGTCGTTCCTGCGCAATGAAGAGGTGGTCGAGGA
ATTCAGTCCGGTCGATATCAATGCACTGGTGGATGCCATCGCGGAAGACGCGGCCGAACACGGTCAGAAGGTGACGATCA
GCGGCGAGGTGCCGCCGATCTCGGCGCAACCTCTCGGCCTCAAACGCTGCCTGACGAACCTGGTTGCCAACGCGATTCGA
TACGGTGAAGACGCACACATCCGCCTGATCGATGCGCCGTCGTGTGTGCGGATCCAGATTGCCGATCACGGTCCGGGCAT
CCCGGAGGCGCAACTGGAGCGGGCGCTGGAGCCGTTCTACCGGGTGGAAAGTTCTCGCAACAGGAACACGGGCGGGACGG
GCCTTGGCCTTGCCATTGCGAACGACGTCGTGAAGCGTCACGGTGGGGAGCTGGTGTTGCGCAACGGTCCGGAAGGCGGG
CTGGTGGCGCAGGTCACGTTACCGCGTCGATAG

Upstream 100 bases:

>100_bases
CGCGGGCCGCAGACATGTTTCGGGTTTGCAATAAACGGCTCACATAGCTCCTACATTCGCGGGCGATAATCGCAGCCATT
GTTCGCTGTCGGCCAGAACC

Downstream 100 bases:

>100_bases
GGTGATGGGCTCGGAGCGATCGTTTGCACTGCTCTGTTTCACGCTTGATACAGATTGCTCACAAAGCGGAAACAGCGCGT
GCTTATAGTCGTTTCACACC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MHKPRFDSAFYRLFFVMISIILVMQISAGLLLYKLYSSEPFKPPPGMSAALQWAAAVMIQVMPALISSWIGARMLAAPFR
TLAVGAAELSRNIDAPPIKEIGPVEARQAASVFNTMQASLRRQMSERNRFLAAVSHDLRTPLTRMKLRLRSAQDVELSER
LRDDIDEMTQLLEATLSFLRNEEVVEEFSPVDINALVDAIAEDAAEHGQKVTISGEVPPISAQPLGLKRCLTNLVANAIR
YGEDAHIRLIDAPSCVRIQIADHGPGIPEAQLERALEPFYRVESSRNRNTGGTGLGLAIANDVVKRHGGELVLRNGPEGG
LVAQVTLPRR

Sequences:

>Translated_330_residues
MHKPRFDSAFYRLFFVMISIILVMQISAGLLLYKLYSSEPFKPPPGMSAALQWAAAVMIQVMPALISSWIGARMLAAPFR
TLAVGAAELSRNIDAPPIKEIGPVEARQAASVFNTMQASLRRQMSERNRFLAAVSHDLRTPLTRMKLRLRSAQDVELSER
LRDDIDEMTQLLEATLSFLRNEEVVEEFSPVDINALVDAIAEDAAEHGQKVTISGEVPPISAQPLGLKRCLTNLVANAIR
YGEDAHIRLIDAPSCVRIQIADHGPGIPEAQLERALEPFYRVESSRNRNTGGTGLGLAIANDVVKRHGGELVLRNGPEGG
LVAQVTLPRR
>Mature_330_residues
MHKPRFDSAFYRLFFVMISIILVMQISAGLLLYKLYSSEPFKPPPGMSAALQWAAAVMIQVMPALISSWIGARMLAAPFR
TLAVGAAELSRNIDAPPIKEIGPVEARQAASVFNTMQASLRRQMSERNRFLAAVSHDLRTPLTRMKLRLRSAQDVELSER
LRDDIDEMTQLLEATLSFLRNEEVVEEFSPVDINALVDAIAEDAAEHGQKVTISGEVPPISAQPLGLKRCLTNLVANAIR
YGEDAHIRLIDAPSCVRIQIADHGPGIPEAQLERALEPFYRVESSRNRNTGGTGLGLAIANDVVKRHGGELVLRNGPEGG
LVAQVTLPRR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=274, Percent_Identity=35.036496350365, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=32.8413284132841, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=31.2727272727273, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786783, Length=270, Percent_Identity=26.2962962962963, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1789149, Length=217, Percent_Identity=29.4930875576037, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=29, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=31.2217194570136, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=27.6315789473684, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=30.3643724696356, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=29.3103448275862, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=245, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=27.7056277056277, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789403, Length=272, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=25.7009345794392, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=272, Percent_Identity=25.3676470588235, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=22.8448275862069, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=26.4227642276423, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1788279, Length=248, Percent_Identity=26.6129032258064, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=24.2424242424242, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 36292; Mature: 36292

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKPRFDSAFYRLFFVMISIILVMQISAGLLLYKLYSSEPFKPPPGMSAALQWAAAVMIQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VMPALISSWIGARMLAAPFRTLAVGAAELSRNIDAPPIKEIGPVEARQAASVFNTMQASL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRQMSERNRFLAAVSHDLRTPLTRMKLRLRSAQDVELSERLRDDIDEMTQLLEATLSFLR
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NEEVVEEFSPVDINALVDAIAEDAAEHGQKVTISGEVPPISAQPLGLKRCLTNLVANAIR
CHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
YGEDAHIRLIDAPSCVRIQIADHGPGIPEAQLERALEPFYRVESSRNRNTGGTGLGLAIA
CCCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
NDVVKRHGGELVLRNGPEGGLVAQVTLPRR
HHHHHHCCCCEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure
MHKPRFDSAFYRLFFVMISIILVMQISAGLLLYKLYSSEPFKPPPGMSAALQWAAAVMIQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VMPALISSWIGARMLAAPFRTLAVGAAELSRNIDAPPIKEIGPVEARQAASVFNTMQASL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RRQMSERNRFLAAVSHDLRTPLTRMKLRLRSAQDVELSERLRDDIDEMTQLLEATLSFLR
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NEEVVEEFSPVDINALVDAIAEDAAEHGQKVTISGEVPPISAQPLGLKRCLTNLVANAIR
CHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
YGEDAHIRLIDAPSCVRIQIADHGPGIPEAQLERALEPFYRVESSRNRNTGGTGLGLAIA
CCCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
NDVVKRHGGELVLRNGPEGGLVAQVTLPRR
HHHHHHCCCCEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]