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The map label for this gene is rncS

Identifier: 78065718

GI number: 78065718

Start: 1180579

End: 1181805

Strand: Direct

Name: rncS

Synonym: Bcep18194_A4246

Alternate gene names: 78065718

Gene position: 1180579-1181805 (Clockwise)

Preceding gene: 78065717

Following gene: 78065719

Centisome position: 31.96

GC content: 67.4

Gene sequence:

>1227_bases
ATGCCCCTATCCCAGTTGGAAAGCCGGCTGCGCTACGAATTTCGCAATGCGGAATTGTTGCGCCAGGCTTTGACCCATCG
TAGTCACAGTGCCACGCACAACGAACGGCTCGAGTTTCTCGGCGACTCCGTTCTGAATTGCGCGGTGGCTGCCCTTTTGT
TCCAGCGTTTCAGCAAGCTGGACGAAGGTGATCTGTCGCGCGTACGCGCCAACCTCGTCAAGCAGCAGTCGCTGTACGAA
ATTGCTCAGGCCCTGAATATCTCGGACGGCCTGCGACTCGGCGAGGGCGAGCTGCGCAGCGGTGGGTTCCGCCGCCCGTC
GATCCTCGCGGACGCGTTCGAAGCCATCATCGGGGCAGTATTCCTCGATGGCGGCTTCGAAGCCGCCCAAGGGGTCATCA
AGCGCCTCTATATCCCGATTCTCGACCACATCGATCCGCGCACGCTCGGCAAGGACGCGAAGACGCTGCTGCAGGAATAC
CTGCAGGGGCACAAGATCGCGCTGCCGACTTATACGGTGGTCGCGACGCATGGTGCGGCGCACAATCAGCAATTCGAAGT
CGAATGCACGGTGCCGAAGCTCGACGTGAAGGTGTCGGGCTCCGGTGCGAGCCGGCGCGCGGCCGAGCAGGCCGCGGCGA
AGAAGGCACTCGACGAGGTGATGGCGGCTGCGCCGATGCTGACCACGAAGCCGAAGCGCTCGAAAAACGCGCGTGGGTCG
AAGCATGTCGAACCCGAAATCGTGCCGGGCGTGAAGGGTGTGCAGGAAGCGCTCGACCTGCGCTCGCCGGAGCGGAAGGA
ACGCGCGGCGGCCCGCGAGGCGAGGGCAGCCGGTGCGGCGCCCGCGGCAATCGCTGCAACCGGTACCGAGCCGGCCGCGG
CGCCGATGGCCGCGATTCGTGCGGCGCATGTCGACGCGGCTGCGGAAAAGGGTGAGCGGGCGGTGAAGCCGGCGGCCGAG
AAGGCTGCCGACAAGCCGGCCGAGCGAACCGACAAGGCCGCGGAGAAGCCCGCGGAAGCCGTGCCTGCTGCACGCGCAGC
CGACAAGCCGACTGGCCAGGCAGCCGATCCGGCATCGTCGTCCGCCGACAAGTCTTCCGTCGGTACCGACCCCGCTTCGC
GTGCGGCTGCGCGCACACGTGACGCCGCGGCACCGGATGCCGAGACGCCGCCGGGCGGCGCGAGCCTCGCTGCCGCGCAG
GCGCGCGTGGCCGATGCCGACCACTGA

Upstream 100 bases:

>100_bases
GAACTACTTTAAGAACCGGCGGTAACACCGCCTCGTCACGCCTTTTCGCGTCCGGCCGTGCCGTTTCGGCCCGACCGGCG
CCCGCGTTATACTCCTGCAC

Downstream 100 bases:

>100_bases
ATTGCCCATCGATCGTGCCGCGCGTCGCGCGGCCGTTTCCGAACCTGTCTCCCAAACGATATGAACACTCCCGCTCCTAC
CGGTTTCCGTTGCGGCATGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLTTKPKRSKNARGS
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAAPAAIAATGTEPAAAPMAAIRAAHVDAAAEKGERAVKPAAE
KAADKPAERTDKAAEKPAEAVPAARAADKPTGQAADPASSSADKSSVGTDPASRAAARTRDAAAPDAETPPGGASLAAAQ
ARVADADH

Sequences:

>Translated_408_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLTTKPKRSKNARGS
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAAPAAIAATGTEPAAAPMAAIRAAHVDAAAEKGERAVKPAAE
KAADKPAERTDKAAEKPAEAVPAARAADKPTGQAADPASSSADKSSVGTDPASRAAARTRDAAAPDAETPPGGASLAAAQ
ARVADADH
>Mature_407_residues
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKLDEGDLSRVRANLVKQQSLYEI
AQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEYL
QGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLTTKPKRSKNARGSK
HVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAAPAAIAATGTEPAAAPMAAIRAAHVDAAAEKGERAVKPAAEK
AADKPAERTDKAAEKPAEAVPAARAADKPTGQAADPASSSADKSSVGTDPASRAAARTRDAAAPDAETPPGGASLAAAQA
RVADADH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=26.8722466960352, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=26.8722466960352, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=51.9417475728155, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=32.48730964467, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=32.48730964467, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323895, Length=97, Percent_Identity=38.1443298969072, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17137682, Length=242, Percent_Identity=28.9256198347107, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 42883; Mature: 42751

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCCEEEEEECCCC
HNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLTTKPKRSKNARGS
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAAPAAIAATGTEPAAAPMAAIR
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHH
AAHVDAAAEKGERAVKPAAEKAADKPAERTDKAAEKPAEAVPAARAADKPTGQAADPASS
HHHHHHHHHHCHHHHCHHHHHHHCCCHHHHHHHHHCCHHHCCCHHCCCCCCCCCCCCCCC
SADKSSVGTDPASRAAARTRDAAAPDAETPPGGASLAAAQARVADADH
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFSKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCCEEEEEECCCC
HNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLTTKPKRSKNARGS
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAAPAAIAATGTEPAAAPMAAIR
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHH
AAHVDAAAEKGERAVKPAAEKAADKPAERTDKAAEKPAEAVPAARAADKPTGQAADPASS
HHHHHHHHHHCHHHHCHHHHHHHCCCHHHHHHHHHCCHHHCCCHHCCCCCCCCCCCCCCC
SADKSSVGTDPASRAAARTRDAAAPDAETPPGGASLAAAQARVADADH
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]