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The map label for this gene is maeB [H]

Identifier: 78065189

GI number: 78065189

Start: 601341

End: 603698

Strand: Direct

Name: maeB [H]

Synonym: Bcep18194_A3713

Alternate gene names: 78065189

Gene position: 601341-603698 (Clockwise)

Preceding gene: 78065185

Following gene: 78065190

Centisome position: 16.28

GC content: 65.39

Gene sequence:

>2358_bases
ATGATTGGCGCTACAATGCCGTCGAAGAGTTATTCTAATCCGCCCGCCAAGAGACACATGTCTACCCAAGCCTCCTCCAA
AGCCAAGCTCCGCGAAGCCGCGCTCGACTATCACGAATTCCCGACCCCCGGGAAAATCGCGATCGCCCCGACCAAGCAGA
TGATCAACCAGCGCGACCTCGCGCTCGCATACTCGCCGGGTGTGGCGTACGCGTGCGAGGAGATCGTCGAGAATCCGCTG
AACGCGGCGCGCTTCACCGCGCGCAGCAACCTGGTCGGCGTCGTCACGAACGGTACGGCGGTGCTCGGTCTGGGCAACAT
CGGCCCGCTCGCGTCGAAGCCGGTGATGGAAGGCAAGGCCGTGCTCTTCAAGAAGTTCGCGGGCATCGACGTGTTCGACA
TCGAGCTGAACGAGTCGGATCCGCACAAGCTCGTCGACGTGATCGCCGCGCTGGAGCCGACCTTCGGCGGGATCAACCTG
GAAGACATCAAGGCGCCGGACTGCTTCATCGTCGAGCGCGAAGCGCGCAAGCGGATGAAGATCCCGGTGTTCCACGACGA
CCAGCACGGCACCGCGATCGTCGTGGCCGCGGCCGTCACGAACGGGCTGAAGGTCGTCAACAAGGACATCAAGAAGGTCA
AGCTTGTCGCGTCCGGCGCGGGGGCGGCCGCGCTCGCGTGTCTCGACCTGCTGGTCGACATCGGCCTGCCGATCGAGAAC
ATCATCGTGACCGACCTGGCGGGCGTGGTCTACAAGGGCCGCACCGAGCTGATGGATCCGGACAAGGAGCGTTTCGCCCG
CGAAACGGACGCGCGGACGCTGGCCGAAGTGATCGACGGCGCGGACATCTTCCTCGGCCTGTCGGCTGCCGGCGTGCTGA
AGCAGGAGATGGTGAAGGGCATGGCCGAGCGCCCGCTGATCCTCGCGCTCGCGAACCCGACGCCGGAAATCCTGCCGGAA
CTCGCGCTCGAAGTGCGCCCGGACGCGGTGCTGGCCACGGGCCGCACCGACTACCCGAACCAGGTCAACAACGTCCTGTG
CTTCCCGTTCATCTTCCGCGGCGCGCTCGACGTCGGCGCGACGACGATCACGCGTGAAATGGAAATCGCGGCCGTCAACG
CGATCGCCGAGCTCGCGCAGCACGAGCAGAGCGACATCGTCGCGACCGCGTACGGCATCCAGGACCTGTCGTTCGGGCCC
GAATACCTGATTCCGAAGCCGTTCGATCCGCGCCTGATCGTGAAGATCGCACCGGCCGTCGCGCAGGCCGCGATGGACGG
CGGCGTCGCGACGCGCCCGATCGAGGACATGGAGGCGTACCGCGTCCACCTGCAGCAGTTCGTGTACCACAGCGGCACGA
CGATGAAGCCGATCTTCCAGATCGCGCGCGCCGCGCCGGAAGAGAAGAAGCGCGTTGTGTTCGCGGAAGGCGAAGAAGAG
CGCGTGTTGCGTGCCGTTCAGATCATCGTCGACGAAAAGCTCGCGAAGCCGGTCCTGATCGGCCGCCCGTCGGTGATCGA
GCACCGTATCCAGCGCTACGGCCTGCGCCTGACGCCGGGCACCGACTTCACGGTCGTCAACACCGAGCACGACGAGCGCT
ACCGCGACTTCTGGCAGACGTACTACAAGATGATGGCGCGCAAGGGCATCAGCGAGCAGCTCGCGCGGGTCGAGATGCGC
CGCCGCACGACGCTGATCGGCTCGATGCTGGTGAAGAAGGGCGAAGCGGACGGGATGATCTGCGGCACGATCAGCACCAC
GCACCGCCACCTGCACTTCATCGACCAGGTAATCGGCAAGCGCCCGGGCTGCAGTGTGTACGCGGCGATGAACGGCCTCG
TGCTGCCGGGCCGCCAGATTTTCCTCGTCGACACGCACGTGAACGTCGATCCGACCCCGGAAGAGCTGGCCGAGATCACG
ATCATGGCGGCGGAAGAAGTGCGCCGCTTCGGCATCGAGCCGAAGGTCGCGCTGCTGTCGCACTCGAATTTCGGCACGAG
CAACGCCCCTTCGGCGAAGAAGATGCGCGATACGCTCGCGATCCTGCAGGAACGTGCACCGGAGCTGAAGGTGGACGGCG
AGATGCACGGCGATGTCGCGCTCGACGCGGCGCTGCGCAAGGAAATCCTGCCGGAATCGACGCTGGAAGGCGAAGCGAAC
CTGCTGATCCTGCCGAACATCGATGCCGCGAACATCGCGTACAACCTGCTGAAGACGGCCGCGGGCAACAATATCGCGAT
CGGGCCGATCCTGCTGGGTGCTGCGCAGCCGGTGCACGTGCTGACCGAATCGGCGACCGTTCGCCGCATCGTCAACATGG
CGGCGCTGCTGGTCGCCGACGTGAACGCCACGCGCTGA

Upstream 100 bases:

>100_bases
TGGAAGGAACGGCATTGTACGAGGCGAACGGCGGCGTTCCTGCACCGTTCAGTACAATTTTGTCGCGGCTGTTGCACCCG
AATCGCCGGTCTGGCGGCCG

Downstream 100 bases:

>100_bases
GCCAAAACGAACGCGCCAGGCCGGTCGAACCGGCATGGCGCGTCAGGCAAAATTGTAAACAAAAGCAAAAAAAGAGGCGT
GCCCGCAATGGGCACGCCGC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MIGATMPSKSYSNPPAKRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAYACEEIVENPL
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINL
EDIKAPDCFIVEREARKRMKIPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPIEN
IIVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKGMAERPLILALANPTPEILPE
LALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGP
EYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
RVLRAVQIIVDEKLAKPVLIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQTYYKMMARKGISEQLARVEMR
RRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEIT
IMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAKKMRDTLAILQERAPELKVDGEMHGDVALDAALRKEILPESTLEGEAN
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMAALLVADVNATR

Sequences:

>Translated_785_residues
MIGATMPSKSYSNPPAKRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAYACEEIVENPL
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINL
EDIKAPDCFIVEREARKRMKIPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPIEN
IIVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKGMAERPLILALANPTPEILPE
LALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGP
EYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
RVLRAVQIIVDEKLAKPVLIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQTYYKMMARKGISEQLARVEMR
RRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEIT
IMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAKKMRDTLAILQERAPELKVDGEMHGDVALDAALRKEILPESTLEGEAN
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMAALLVADVNATR
>Mature_785_residues
MIGATMPSKSYSNPPAKRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAYACEEIVENPL
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINL
EDIKAPDCFIVEREARKRMKIPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPIEN
IIVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKGMAERPLILALANPTPEILPE
LALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGP
EYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
RVLRAVQIIVDEKLAKPVLIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQTYYKMMARKGISEQLARVEMR
RRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEIT
IMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAKKMRDTLAILQERAPELKVDGEMHGDVALDAALRKEILPESTLEGEAN
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMAALLVADVNATR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI62420882, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI62420880, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI239049447, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI4505145, Length=354, Percent_Identity=27.4011299435028, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788806, Length=753, Percent_Identity=62.0185922974768, Blast_Score=972, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=322, Percent_Identity=33.2298136645963, Blast_Score=162, Evalue=7e-41,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=31.1111111111111, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17537199, Length=464, Percent_Identity=25.4310344827586, Blast_Score=76, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=30.9623430962343, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362674, Length=423, Percent_Identity=27.8959810874704, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281362672, Length=423, Percent_Identity=27.8959810874704, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21356279, Length=423, Percent_Identity=27.8959810874704, Blast_Score=87, Evalue=7e-17,
Organism=Drosophila melanogaster, GI78707242, Length=408, Percent_Identity=25.9803921568627, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707238, Length=408, Percent_Identity=25.9803921568627, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=26.3610315186246, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24646388, Length=349, Percent_Identity=28.080229226361, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=28.9855072463768, Blast_Score=73, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 85314; Mature: 85314

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGATMPSKSYSNPPAKRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCE
ALAYSPGVAYACEEIVENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKA
EEEECCCHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHH
VLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVEREARKRMK
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHCCCC
IPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPIEN
CCEEECCCCCCEEEEEEHHHCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCHHH
IIVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKG
HHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
MAERPLILALANPTPEILPELALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGA
HHCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCC
TTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHH
AQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCEEEEECCCHH
RVLRAVQIIVDEKLAKPVLIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQT
HHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHH
YYKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCC
RPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEITIMAAEEVRRFGIEPKVALLS
CCCCEEEEECCCEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
HSNFGTSNAPSAKKMRDTLAILQERAPELKVDGEMHGDVALDAALRKEILPESTLEGEAN
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMAALLVAD
EEEECCCCHHHHHHHHHHHCCCCCEEECCEEECCCCCHHHHHCHHHHHHHHHHHHHHHHC
VNATR
CCCCC
>Mature Secondary Structure
MIGATMPSKSYSNPPAKRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCE
ALAYSPGVAYACEEIVENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKA
EEEECCCHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHH
VLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVEREARKRMK
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHCCCC
IPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPIEN
CCEEECCCCCCEEEEEEHHHCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCHHH
IIVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKG
HHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
MAERPLILALANPTPEILPELALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGA
HHCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCC
TTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHH
AQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCEEEEECCCHH
RVLRAVQIIVDEKLAKPVLIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQT
HHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHH
YYKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCC
RPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEITIMAAEEVRRFGIEPKVALLS
CCCCEEEEECCCEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
HSNFGTSNAPSAKKMRDTLAILQERAPELKVDGEMHGDVALDAALRKEILPESTLEGEAN
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAQPVHVLTESATVRRIVNMAALLVAD
EEEECCCCHHHHHHHHHHHCCCCCEEECCEEECCCCCHHHHHCHHHHHHHHHHHHHHHHC
VNATR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]